PubMed Health⌕ Search

Biomedical subjects

C Malloy

Publications and source records attributed to C Malloy.

At least 19 recordsLinked to original sources
PubMed2001

Quantifying tracer levels of (2)H(2)O enrichment from microliter amounts of plasma and urine by (2)H NMR.

A simple and sensitive (2)H NMR measurement of (2)H(2)O enrichment from a 10 microl volume of body fluid is presented. The method allows (2)H-enrichment levels of 0.1% or above to be rapidly determined from 10 microl of plasma or urine. The measurement is insensitive to the presence of plasma protein, allowing direct analysis of (2)H(2)O enrichment from native plasma samples. Magn Reson Med 45:156-158, 2001.

Animals↗
PubMed1998

Managed care and ethical implications in telephone-based health services.

Telephone-based health services is a fast growing subspecialty of nursing practice. It is used in demand management and managed care organizations in a highly unregulated environment. The article presents background information and identifies the need for systematic studies of ethical implications inherent in telephone-based practice. Conclusions suggest that nurses need to become actively involved in ethical decision making related to this area of practice.

Decision Making, Organizational↗
PubMed1997

Managed care. What is its impact on nursing education and practice?

Market forces present the nursing profession with an urgency to prepare gerontological nurses to assume significant roles in the managed care industry. An understanding of the current managed care environment underscores the need for training. Nurses require a "managed care" skill-set encompassing a firm grasp of the organization, financing, delivery, and policy implications of managed care as well as advanced practice clinical skills and a sound business orientation. The importance of the consumer as a significant player in managed care is highlighted.

Aged↗
PubMed1991

A monoclonal antibody capture ELISA to detect antibody to border disease virus in sheep serum.

An enzyme-linked immunosorbent assay (ELISA) has been developed to detect antibody to border disease virus (BDV) in sheep serum. A monoclonal antibody bound to 96-well microplates was used to capture antigen from detergent-solubilised BDV-infected cells. Single dilutions of test sera were then added to wells containing bound BDV antigen and control wells containing uninfected cell lysates. Specific antibody to BDV was detected by an anti-ovine IgG antiserum conjugated with horseradish peroxidase and the results expressed as ELISA units with reference to a standard curve. Sequential sera from 16 experimentally infected sheep and single sera from 103 sheep involved in a field outbreak were tested in the ELISA and for neutralising antibody. There was good qualitative correlation between the two tests.

Animals↗
PubMed1991

Identification of cattle infected with bovine virus diarrhoea virus using a monoclonal antibody capture ELISA.

A monoclonal antibody capture enzyme linked immunosorbent assay (ELISA) has been developed to detect pestivirus-specific antigen in the leucocytes of cattle infected with bovine virus diarrhoea virus (BVDV). A blind trial was conducted to compare the specificity of the ELISA with conventional tissue culture virus isolation on 215 blood samples submitted for BVDV diagnosis from cattle throughout Scotland. One hundred and sixty seven samples were negative by both ELISA and virus isolation and 47 samples were positive by both tests. One blood was negative by ELISA and positive by virus isolation.

Animals↗
PubMed1990

Underrecognition of morbidity from stings of the red imported fire ant in the southeastern United States.

This cross-sectional study was conducted to determine the health-seeking behaviors of a group of patients stung by red imported fire ants (RIFA) and the number of nursing referrals resulting in treatment. The following two research questions were asked: (1) Is there a delay in seeking the care of a board-certified allergist for symptoms of fire ant hypersensitivity? (2) Are nurses referring patients for treatment? The entire population of board-certified allergists in Alabama, Georgia, and South Carolina (n = 98) was sampled. A questionnaire was developed for the office nurses to use to collect information from allergy patients actually receiving fire ant injections (n = 257). Each patient reported on the reaction, when it occurred as well as age, sex, and county of residence. Descriptive statistics revealed that a delay of a month or more in seeking care of an allergist was experienced by 154 (56%) of patients who completed the questionnaire. The average delay was 1.8 years. The main source of referrals was a general practitioner or emergency room personnel. Nursing and other health professionals must recognize the problem and to institute prompt referral for treatment. In areas where RIFA colonies are spreading, they have to be fully informed and trained in effective primary and secondary techniques to prevent serious reaction to the stings of these ants.

Adolescent↗
PubMed1990

The homeless: social isolates.

Within the last 10 years, homelessness has emerged as one of the leading social problems in the United States. This article contains the findings of a descriptive study of the characteristics and health status of a homeless population in a southeastern city. The homeless population is of interest to nurses because it is representative of a specific disadvantaged group, seriously at risk for a myriad of physical and mental problems. The theoretical model, Social Disaffiliation, can serve as a basis for intervention with a variety of underserved or unserved population groups and the data presented provide opportunities for designing nursing intervention strategies. The study was conceived as a way to gather empirical evidence about the specific health-care needs of the community's homeless, to generate a data base on which to estimate that need, and to use the findings to support the establishment of an innovative practice model, a nurse-managed clinic. The literature suggests that on-site clinics, located in emergency shelters, are effective approaches to providing acceptable and accessible health care to the homeless. Nurses are well prepared to be a key part of the solution to one of the most serious problems facing health care in the U.S. today.

Adult↗
PubMed1990

Cytomegalovirus infection in a neonatal intensive care unit. Subsequent morbidity and mortality of seropositive infants.

In a study of blood transfusion and cytomegalovirus (CMV) infection in 385 infants, 5 (8%) of 60 seropositive infants with birthweights less than or equal to 1250 g acquired CMV. Four infants had become seronegative by the time of viral excretion and demonstrated significant morbidity with one death. Morbidity included variant (atypical) lymphocytosis, thrombocytopenia, Staphylococcal epidermidis and Candida parapsilosis infections, and respiratory deterioration. Interestingly, the infant who exhibited only minimal morbidity was seropositive at the time of viral excretion. CMV seropositivity at birth may not protect low birthweight (LBW) infants from the morbidity and mortality associated with CMV infection.

Antibodies, Viral↗
PubMed1989

Metabolic studies on citrate synthase mutants of yeast. A change in phenotype following transformation with an inactive enzyme.

We have studied the growth on acetate, the metabolism of acetate enzymes, and respiration of a series of citrate synthase mutants of Saccharomyces cerevisiae. The results confirmed and extended our previous observation that cytosolic citrate synthase is not necessary for growth on acetate. Deletion of mitochondrial citrate synthase (CS1) protein resulted in changes in metabolites, decrease in the amounts of pyruvate and alpha-ketoglutarate dehydrogenase complexes, reduced mitochondrial respiration of citrate and isocitrate, and an inability to grow on acetate. Using site-directed mutagensis, we constructed two separate CS1 proteins with mutations in the enzyme's active site. The mitochondria of cells carrying either site-directed mutagenized CS1 contained the inactive citrate synthase protein. With one mutant in which His313 was replaced with a glycine (CS1/H313G), growth on acetate was restored, and mitochondrial respiration of citrate and isocitrate increased toward parental levels as did the levels of several enzymes. With the other mutant CS1 in which Asp414 was replaced with a glycine (CS1/D414G), no growth on acetate or changes in other parameters was observed. We propose that the characteristics of the strain carrying the CS1 with a H313G mutation result from the formation of an intact Krebs cycle complex by the inactive but structurally unchanged H313G protein.

Acetates↗
PubMed1989

Collaboration projects between nursing education and nursing service: a case study.

Collaboration refers to a variety of efforts to blend nursing education and nursing service. A regional planning agency in Southwestern Pennsylvania assumed a strategic role in developing a collaboration action plan which was expressed in three pilot demonstration projects involving an associate degree, a baccalaureate, and a diploma program with their respective service partners. The purpose of this 2 year evaluation case study was to assess the extent to which the three demonstration projects met their stated goals and objectives. The sample was self selected from the pool of nursing education programs and hospitals in the ten county Southwestern Pennsylvania planning region based on willingness to participate and compliance with project criteria. Suchman's model was used as the framework from which to evaluate the projects. Program participants indicated that the project resulted in enhancement of the school-agency relationship, more confident, competent students, and increased enthusiasm among staff who perceived they had a stake in the educational process. This study has implications for nursing practice, education and research. The implementation of well-planned collaboration projects yield many benefits, chief of which is enhanced co-operation between nursing service and nursing education. The benefits are valuable for international colleagues who may be testing out similar approaches in their respective countries.

Education, Nursing↗
PubMed1988

Cytomegalovirus infection in a neonatal intensive care unit. Blood transfusion practices and incidence of infection.

We studied blood transfusion variables and cytomegalovirus (CMV) infection in 385 infants admitted to the Duke University Medical Center, Durham, NC, neonatal intensive care unit over 14 months. Cytomegalovirus antibody titers were measured at birth and monthly thereafter. Urine cultures for CMV were performed regularly. Infants admitted in the first six months (n = 197) received conventionally prepared blood. Infants admitted in the remaining eight months (n = 188) were given frozen, deglycerolized blood. Of the 105 infants weighing 1250 g or less (low birth weight [LBW]), 90 (86%) received transfusions. Two hundred eighty infants weighed more than 1250 g (non-LBW), and 111 (40%) of these were given blood. In the first six months of the study, three infants had CMV viruria. One case was congenital; two were acquired. Both infants who acquired infection were antibody-positive at birth and received multiple transfusions. In the remaining eight months, five infants had CMV viruria. Two cases were congenital; three were acquired. The three infants who acquired infection were antibody-positive at birth and received multiple transfusions. Our study demonstrates that infants with an LBW are more likely to receive blood transfusion and to be given significantly more blood than non-LBW infants. There was no difference in the number of infants acquiring CMV in the two periods despite the use of different preparations of blood.

Antibodies, Viral↗