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Biomedical subjects

C Mamì

Publications and source records attributed to C Mamì.

28 records · Page 2Linked to original sources
PubMed1986

Effects of intravenous TRH on growth hormone and cortisol serum levels in children and adolescents with insulin dependent diabetes mellitus.

The effects of an iv thyrotropin releasing hormone (TRH) bolus on serum growth hormone (GH) and cortisol levels were evaluated in 59 children and adolescents with insulin dependent diabetes mellitus (IDDM) and in 24 healthy, age-matched control subjects. In the IDDM group GH baseline levels sharply rose within 30 min after TRH and successively normalized. On the contrary, TRH injection failed to affect GH serum concentrations in the control group. The GH increase after TRH in IDDM patients was positively correlated to age, but unrelated to other variables, such as sex, pubertal stage, duration of disease, glycemia, glycosylated hemoglobin, thyrotropin and T4 concentrations. Twenty-one out of 59 diabetics and only 1/24 controls exhibited a paradoxical GH response to TRH, arbitrarily defined as a precocious increase (within 30 min), of more than 100% with respect to the baseline value, associated with a GH peak greater than 10 ng/ml. Eighteen IDDM patients underwent a second TRH test 12 to 24 months later and substantially exhibited the same GH pattern documented the first time. The mechanism responsible for such anomalous GH responsiveness to TRH in IDDM is unclear. However, it cannot be attributed to a nonspecific stress reaction, as proven by the lack of a concomitant increase of cortisol serum levels in the same subjects.

Adolescent↗
PubMedDate not supplied

[Health status of neonates born to immigrants at the University Polyclinic of Messina in 1993-1998. A case-control study].

The aim of the present case-control study was to verify the incidence and the state of health of the neonates born of extracommunity parents (E.C.) in the our hospital throughout the years 1993-1998. For every neonate born of E.C. we have analyzed two italian neonates born immediately before and after. The parameters analyzed were: nationality, age, and job of the parents, abortions, number of ecography carried out during pregnancy, parity, delivery, gestational age (G.A.), weight at birth, Apgar score, malformations, perinatal mortality and neonatal morbidity. Statistical analyses were performed with the T Student test and the chi-square test. Throughout the 1993-1998 years are born 9285 neonates. Of these 199 (2.4%) were E.C. The 45% of the E.C. derived from the Far East and only the 10% were nomad. The 86% of the E.C. had a job. In the E.C. group the multiparity was significantly higher than in italian group. G.A., birth weight, number of malformation, neonatal morbidity, and perinatal mortality were the same in the E.C. and in the italian neonates. Our data, in disagreement with other Authors, demonstrate that in our hospital the state of health of the E.C. and italian neonates is not different. Because in the our analysis it results that the greater number of E.C. parents had a job, it is likely that the non-observed increased of perinatal mortality and morbidity in the neonates born of E.C. depends on the social integration of E.C.

Case-Control Studies↗