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Biomedical subjects

C Margo

Publications and source records attributed to C Margo.

7 recordsLinked to original sources
PubMed1984

Idiopathic solitary granuloma of the uveal tract.

We reviewed the clinical and histopathologic features of 11 cases of a distinctive solitary necrotizing granuloma of the uveal tract. No clinical or histopathologic cause for the lesion could be found in any case. The granulomas were located between the pars plana ciliaris and the equator and had an annular configuration. Uveal effusion and total retinal detachment were present in each eye. Uveitis was unilateral in all cases, and all patients were in otherwise good health. The morphologic characteristics of the solitary necrotizing granuloma suggest an infection, but the cause of this previously unreported entity remains to be determined.

Adult↗
PubMed1983

Retinocytoma. A benign variant of retinoblastoma.

Six examples of a distinctive benign retinal tumor, occurring in five children and treated only by enucleation, were studied by light and electron microscopy and tested for S-100 protein, a glial-cell tissue marker. The small placoid, noninvasive lesions were composed entirely of benign-appearing cells with numerous fleurettes. These tumors showed no necrosis or mitotic activity. Ultrastructurally, they were composed predominantly of neuronal cells exhibiting photoreceptor differentiation. Some tumor cells had cytologic features of Müller's fibers and other glial cells that in one lesion stained positively for S-100 protein. In two patients there was a family history of retinoblastoma. All children were alive and well at follow-up examinations conducted three to 14 years after enucleation. To expand our concept of retinoblastoma to include this benign variant, we propose the term "retinocytoma." Although clinically and morphologically distinct from retinoblastoma, retinocytoma should carry the same genetic implication as its malignant counterpart.

Child, Preschool↗
PubMed1983

Subacute zygomycosis of the orbit.

A zygomycotic (phycomycotic) orbital cellulitis developed in a healthy 9-year-old boy. Because of the involved tissue's unfamiliar histopathologic features, an initial diagnosis of eosinophilic granuloma was made and appropriate treatment was delayed for more than six months. The patient's slowly progressive form of zygomycosis was clinically and morphologically similar to that described in previously recorded cases. All three cases occurred in otherwise healthy children living within the United States. Their involved tissues had mixed histopathologic features of chronic granulomatous entomophthoramycosis and acute necrotizing mucormycosis; however, unlike entomophthoramycosis, the fungi in these cases may invade the walls of blood vessels and cause severe tissue necrosis. We believe that these three cases represent a distinct clinicopathologic variant of facial-cranial zygomycosis not previously delineated in the literature. Although they are aggressive, these infections are not as fulminant as in classic mucormycosis, but can nevertheless be lethal.

Child↗
PubMed1983

Cryotherapy and photocoagulation in the management of retinoblastoma: treatment failure and unusual complication.

Ophthalmologists treating children with retinoblastoma need to be aware of the limitations of new forms of therapy and their complications. For this reason the following case of a child with a small peripheral retinoblastoma that failed to respond to treatment with both cryotherapy and photocoagulation is recorded. The development of a rapidly growing juxtapapillary lesion prompted immediate enucleation. Histological examination revealed viable tumor cells remaining in the areas that were previously treated. The juxtapapillary mass consisted of optic nerve and detached peripapillary retina that were "dragged" towards the tumor by a thick fibrocellular membrane containing many myofibroblasts.

Cryosurgery↗
PubMedDate not supplied

Management of periocular molluscum contagiosum in children.

Because there are no data concerning the association between periocular molluscum contagiosum (POMC) and toxic conjunctivitis, and since there are no established guidelines of acceptable treatment, we surveyed pediatric ophthalmologists in North America in order to analyze the results of their cumulative experience dealing with the disease. Approximately half of 341 cases of POMC were not associated with conjunctivitis; however the majority of cases were treated, occasionally with chemical ablatives or cautery. Many ophthalmologists preferred to use general anesthesia in the treatment of POMC. POMC was noted not only to regress spontaneously, but was also noted to recur after treatment. Because of the benign nature of the infection, indications to treat asymptomatic POMC are not clearly established.

Child↗