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Biomedical subjects

C Mattout

Publications and source records attributed to C Mattout.

At least 19 recordsLinked to original sources
PubMed1995

Clinical evaluation of guided bone regeneration at exposed parts of Brånemark dental implants with and without bone allograft.

This investigation evaluated guided bone regeneration with a polytetrafluoroethylene barrier membrane at exposed parts of Brånemark dental implants with and without concomitant use of decalcified freeze-dried bone allograft. Density of the regenerated tissue was also determined using a No. 23 probe at a pressure of 25 g and was graded from 1 to 5. The higher index was associated with a higher resistance of newly formed tissue to the pressure of the probe. In 19 patients, 23 defects were treated by barrier membrane alone and 11 defects by bone allograft with barrier membrane. The width and the depth of the defects were determined at the time of the implant placement and at the second-stage implant surgery. When success was defined as 0 mm of residual defect, the mean success rate was 68% for the membrane group and 90% for the membrane group with bone allograft, with no statistically significant difference between the two treatment groups. The two groups did not demonstrate a significant difference in median density index. There was a significant positive relationship between time of membrane coverage and density index. A density index of 4 was only recorded after 7 months of membrane coverage. The present findings suggest beneficial clinical effect with the use of membrane alone and freeze-dried bone allograft with membrane for guided bone regeneration. This study proposed the use of a novel density index for clinical evaluation of regenerated tissue.

Adult↗
PubMed1990

[Function of polynuclear neutrophils in patients with juvenile periodontitis and rapidly progressing periodontitis].

It is generally assumed that early onset forms of periodontal disease (including Juvenile and Rapidly Progressive Periodontitis) are associated with a defect in neutrophil behaviour. We have investigated neutrophil functions in patients with Juvenile (J.P.) and Rapidly Progressive Periodontitis (R.P.P.). In the group of J.P. patients the directed mobility (FMLP and zymosan activated plasma) is significantly decreased. The superoxide generation in response to FMLP decreases while the PMA response is normal. In the group of R.P.P. patients no significant abnormality has been reported.

Aggressive Periodontitis↗
PubMed1990

[Impairment of neutrophil functions: study of a family with a case of juvenile periodontitis].

Neutrophil function was assessed in family in which only one member suffered from Juvenile Periodontitis (JP). Directed mobility (fMet-Leu-Phe and zymosan-activated plasma) was decreased in all siblings without involving a seric inhibitor. Adhesion was studied by a new method which allows for the evaluation of both adhesive rate and binding strengths. The latter parameters were decreased in the parents neutrophils, but remained increased in a set of twin sisters. The specific receptor induced phagocytosis was altered in all members of the family (FC receptor: IgG-SCR, C3b and mannosylfucosyl receptor: zymosan). The superoxide generation in response to fMet-Leu-Phe was decreased while the PMA response was almost normal. These results suggest an overall abnormality of ligand-receptor interactions (C5a, fMet-Leu-Phe, Fc and C4b receptors), this defect seems to involve some membrane characteristics and underlines the absence of correlation between PMN deficiency and the clinical expression of J.P.

Adult↗
PubMed1990

[Guided tissue regeneration: clinical and microscopic study].

A case of furcation involvement of a maxillary molar is reported. The treatment consisted in applying the concept of Controlled Tissue Regeneration using a Goretex membrane. After removal of the membrane the result is satisfactory. The membrane is then examined under transmission electronic microscope. The lateral aspect of the membrane (in contact with the proliferating epithelial tissue) show a marked bacterial proliferation.

Adult↗
PubMed1989

[Cellular competition and healing].

Different therapeutic solutions have been tried to obtain a new attachment. Several animal experiments have studied cellular colonization of radicular surfaces exposed to the disease then planed. Only the cells from the periodontal ligament seem to be able to form a new attachment. The interposition of a membrane seem to prevent gingival and osseous tissues to interfere with the periodontal ligament. The periodontal ligament cells colonize then the radicular surface.

Animals↗
PubMed1984

[Wound healing of a bone defect following a bone graft combined with a desmodontal tissue graft].

An experimental periodontitis was produced in the upper right and left maxillary molar regions of three dogs. The apical zone of the bony defects were marked by cutting grooves into the root surfaces. The right side was used as a control while on the left side, the bony defect was treated with a graft of ligament tissue. The graft was obtained from a neighbouring area after removing the external wall of bone and sampling with a bone chisel. Four months after the grafting the dogs were sacrificed and an optical microscopic study was performed. One of the dogs died three days after operation. In the other two dogs a reattachment was observed in the groove on the control side: coronally to the groove, a long epithelial attachment was present between the radicular wall and the connective tissue. On the experimental side of dog 1, a reattachment was obtained up to the level of the cemento-enamel junction. In dog 2, a complete failure was noted since an important epithelial growth has migrated and invaded the radicular groove.

Animals↗