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Biomedical subjects

C Maylin

Publications and source records attributed to C Maylin.

46 records · Page 3Linked to original sources
PubMed1979

[Prevention of sequelae after transcutaneous radiotherapy for epitheliomas of the oral cavity (author's transl)].

Close cooperation between the radiotherapist, surgeon, and patient is necessary in order to prevent sequelae following transcutaneous radiotherapy for epitheliomas of the oral cavity. The most effective therapeutic results combined with a minimum of sequelae are obtained by the use of a good irradiation technique, close supervision, careful treatment of any oral or dental affection, prescribing simple medications only, and stopping the use of tobacco and alcohol.

Humans↗
PubMed1979

[Factors favouring necrosis after curietherapy for oral cavity epitheliomas (author's transl)].

The authors studied the factors which favour necrosis after curietherapy, in a series of 82 patients with epithelioma of the oral cavity and a previous series of 280 cases. The principal factor is the size of the tumor. The other factors (macroscopic appearance, dose, quantity of radioactive material, degree of inhomogeneity, distance between the lines, association with external irradiation), are or only moderate importance, as shown by the variations observed, though they are difficult to evaluate in an exact manner, partly for methodological reasons. The frequency of necrosis of bone tissue is directly relaxed to the number of radioactive lines in contact with the maxilla. Alcohol and tabacco abuse have a definite influence but this cannot be calculated. In conclusion, therefore, it would appear possible to reduce the frequency of necrotic lesions by reducing the tumoral size by curietherapy, by applying no more than 2 lines in contact with the mandible for bony necrotic lesions, and by stopping the abuse of alcohol and tobacco.

Humans↗
PubMed1979

[Iridium 192 interstitial radiotherapy of carcinoma of the penis. Carcinologic results, dermatologic evaluation (about 87 cases) (author's transl)].

87 cases of epidermoid carcinoma of the penis treated by Ir 192 interstitial radiotherapy are studied. The 5 years survival rate, estimated on a 51 patients group, is 61 p. 100. Among these 51 patients, 12 had a local recurrence. The post-radiotherapy early reaction is estimated on a 79 patients group, with a mean duration of 3, 4 months. The early reaction is correlated to tumor size and not correlated to number of radio-active lines. The later dermatologic evolution is studied in 59 patients. In 22 cases, the scar remained supple, without any further local change. Local changes occurring in the 37 other cases are studied in their clinical aspect, signification and frequency. Of 34 patients followed longer than 40 months, 14 had local complications with 4 cases of local recurrence. The carcinologic reliability of this method is similar to that by surgery. It seems however it must be restricted to tumors limited to glans penis.

Adult↗
PubMed1977

[Isotopic bone examination in operable breast cancer].

In the pre-treatment work-up in breast carcinoma cases the bone scan findings could be of major interest. If the presence of occult metastases is discovered management may be modified accordingly. In a group involving 78 cases of breast carcinoma, classified as primary, operable, in three cases only scintigraphy revealed bone metastases before they produced clinical and radiological signs. In two of them there was agreement, in one disagreement over the findings. Moreover, in 5 cases a bone metastasis was revealed and immediately confirmed on a complete bone assessment.

Bone Neoplasms↗
PubMed1977

[Radical radiotherapy of breast cancer. Experience of Créteil].

Since 1961, we have treated 400 cases of breast cancers by radical radiotherapy (December 1976). The TNM classification of cases is: 25 per cent T1, 55 per cent T2, 20 per cent T3. 80 per cent of patients are N0 or N1a, 20 per cent are N1b. The therapeutic protocal is: for T1 lesions, lumpectomy plus radical radiotherapy, then boost dose with electrons to the axilla (24 Gy) and to the internal mammaryzone (15 Gy), and finally boost dose to the zone of the breast tumor by Iridium 192 implant therapy (25 Gy);--for T2 and T3 lesions, radiotherapy alone with a higher boost dose to the breast tumoral zone (37 Gy). The mammary tumor (or the tumoral zone) receives a total dose between 70 Gy (T1) and 90 Gy (T2 and T3). The five year results for 328 patients with at least one year follow up (actuarial calculations) yield a survival of 89 per cent T1, 84 per cent T2, and 66 per cent T3. The local recurrences are 8 per cent T1, 10 per cent T2, and 26 per cent T3; they can be rectified, under the condition of regular surveillance, by radical surgery. As to the cosmetic results, they are in one half of the cases quite good, in most others satisfactory, in a few poor. We add a prophylactic chemotherapy in the cases with high metastatic risk, i.e. T3 or N1b cases. This therapeutic protocol seems to be highly recommendable for T1 tumors, acceptable for T2, disputable for T3.

Breast Neoplasms↗
PubMed1977

[81 cases of Hodgkin's disease treated with extensive radiotherapy, including 65 with primary MOPP chemiotherapy (author's transl)].

Study 81 cases of Hodgkin's disease at stages I, II or III led to the following conclusions from a therapeutic standpoint (in relation to the apparent results obtained): The addition of chemotherapy on the form of three courses of MOPP before irradiation improved the results of the latter on the one hand and, principally, by reducing the number of failures and, secondly, by reducing the complications. The addition of chemoprophylaxis by MOPP in patients in complete remission as a result of initial treatment, involving an association of 3 courses of MOPP followed by radiotherapy, was not shown to be useful. A major factor in prognosis would to be the clinical and radiological situation after the first three courses of MOPP (in the context of combined MOPP and radiotherapy) since, despite the later radiotherapy, numerous failures were noted in the absence of remission after the three MOPP treatments, whilst failure rarely occurred under the opposite set of circumstances. This is important, since modest treatment would seem to suffice in patients reacting well to three initial MOPP treatments, whilst it is essential to reinforce it when this is not the case.

Drug Therapy, Combination↗
PubMedDate not supplied

[Current treatment of Rendu-Osler disease, excluding radiation].

All the methods available to O.-R.-L. practitioners for the treatment of epistaxis in Rendu-Osler disease are reviewed. In an emergency, gentleness is essential. Over the long term, procrastination for as long as possible is advisable. Super-selective arteriography and embolization are of great value in an emergency and can give some good long-term results. In fact, there is not one exclusive curative therapy. Estrogenotherapy has its advocates. Saunder's dermoplasty gives variable results, but these can be improved upon if a broad access route is used and dermoplasty extended to above and behind the nasal fossae. Because of its aggressive nature, irradiation must be kept as a last resort.

Blood Transfusion↗
PubMedDate not supplied

[Rendu-Osler disease treated by endonasal radiotherapy (evaluation of 62 cases)].

Two groups of patients were treated by plesiocurietherapy. The first group of 17 patients received only one exposure to radium (between 1949 and 1960). The second group received one or more doses of irridium 192 (between 1960 and 1973). The average period for stabilization of the disease was 13,2 months with radium and 20,4 months with irridium. Unfortunately, this does not give a permanent cure and, for irridium 192, the percentage of successes is only 30 p. 100 after 5 years. Logically, radiotherapy with irridium 192 should only be used when other methods have failed. The progressive accumulation of radio-lesions may, in fact, make the use of other techniques impossible.

Epistaxis↗