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Biomedical subjects

C Maynard

Publications and source records attributed to C Maynard.

At least 55 records · Page 3Linked to original sources
PubMed1997

Association of gender and survival in patients with acute myocardial infarction.

BACKGROUND: During the last 5 years, many studies have produced conflicting results concerning the survival of women hospitalized with acute myocardial infarction (AMI). OBJECTIVE: To determine if gender is associated with hospital mortality and long-term survival in individuals with AMI. METHODS: This prospective study included 4255 consecutive women (34%) and 8076 (66%) men who developed AMI in 19 Seattle, Wash, area hospitals between January 1988 and June 1994. Key information was abstracted from hospital records and entered in the Myocardial Infarction Triage and Intervention registry database. In addition, data concerning survival and rehospitalization were obtained from the state of Washington and linked to the Myocardial Infarction Triage and Intervention registry. RESULTS: In comparison with men, women were 8 years older, more often had history of congestive heart failure, hypertension, or diabetes mellitus, and less often had history of myocardial infarction or coronary surgery. During hospitalization, women were less likely to undergo coronary angiography, thrombolytic therapy, coronary angioplasty, or bypass surgery. After adjustment for covariates, women were 20% more likely to die in the hospital (odds ratio, 1.22; 95% confidence interval, 1.06-1.39), yet long-term survival was similar in the 2 groups (hazard ratio, 0.97; 95% confidence interval, 0.90-1.05). The use of thrombolytic therapy or revascularization during the index hospitalization did not change the association between gender and survival. CONCLUSIONS: All things being equal, women with AMI were more likely to die in the hospital, yet survival after hospital discharge did not differ according to gender. Appropriate treatment to reduce hospital mortality in women is needed.

Aged↗
PubMed1997

[Mesenteric ischemia in hemodialyzed patients].

OBJECTIVES: Mesenteric ischemia is uncommon in the general population but is frequently encountered in chronic hemodialysis patients. We present here four cases which occurred in our unit within one year while only six cases had been observed in the preceding twenty years. OBSERVATIONS: Four chronic hemodialysis patients (age: 57 to 76 years) with renal failure due to diffuse atheromatous disease, presented non-occlusive mesenteric ischemia. One patient died and one underwent resection of the colon. For the final two patients, prophylactic therapy was initiated. DISCUSSION: Mesenteric ischemia is a severe condition which appears to occur more frequently in end-stage renal disease. In the chronic hemodialysis patient excessive ultrafiltration or a too rapid filtration rate can favor ischemia. Prophylactic measures must be taken at the first sign of ischemia, especially since clinical and biological features of mesenteric ischemia remain largely non-specific.

Aged↗
PubMed1997

Racial differences in the utilization of public mental health services in Washington State.

This study analyzed racial differences in the use of public outpatient mental health services in four regions of Washington State. Patients in this study were enrolled in the state's mental health management information system, which contains detailed information about patient characteristics and service utilization. There were distinct racial differences with respect to baseline characteristics, and even after adjusting for these characteristics and region of the state as well, racial differences in the type and amount of services used persisted. In particular, African-Americans were more likely to use crisis services and were less likely to use individual or group treatment. This previously reported finding requires further exploration.

Adolescent↗
PubMed1997

Comparison of teaching the basic electrocardiographic concept of frontal plane QRS axis using the classical versus the orderly electrocardiogram limb lead displays.

This study compares the effectiveness of teaching the calculation of frontal plane QRS axis with the use of the classical versus the orderly electrocardiographic limb lead display. Eighty-three students from two environments were randomized into two groups and were taught to determine frontal plane axis with one of the methods. The accuracy and time to determine the axis were tested on 10 electrocardiograms. In the United States the group using the classical display achieved 4.2 (+/-2.7) correct answers, whereas those using the orderly method achieved 6.8 (+/-3.0) (p = 0.0006). The classical group used 9.2 (+/-2.8) minutes to complete the test, whereas the orderly group needed 7.2 (+/-2.0) minutes (p = 0.015). The results achieved in Sweden were similar. The use of the orderly electrocardiographic limb lead display results in greater diagnostic accuracy in less time than the classical display when determining the frontal plane QRS axis.

Adult↗
PubMed1997

Long-term implications of racial differences in the use of revascularization procedures (the Myocardial Infarction Triage and Intervention registry).

The purpose of this study was to determine if less intensive use of revascularization procedures in black patients influenced the long-term survival of patients hospitalized for acute myocardial infarction (AMI) in metropolitan Seattle. From January 1988 through June 1994, AMI developed in 420 (4%) black and 10,834 white patients before hospital discharge or death. Black patients were 6 years younger, more socioeconomically disadvantaged, and had more hypertension, diabetes, and less prior coronary surgery. Similar proportions of black and white patients received thrombolytic therapy or cardiac catheterization. However, during hospitalization, 18% of black patients underwent coronary angioplasty compared with 26% of white patients (p = 0.0004); coronary artery bypass surgery was also used less frequently in black patients (7% vs 12%, p = 0.002). Unadjusted 2-year survival was 79% for black patients and 77% for white patients (p = 0.12). After adjusting for age, clinical variables, and the use of cardiac catheterization, thrombolytic therapy, and revascularization, race was not associated with long-term survival (hazard ratio = 0.92, 95% confidence interval = 0.73 to 1.17). Despite the less intensive use of revascularization procedures in black patients in Seattle, long-term survival after AMI was similar in the two groups of patients.

Age Factors↗
PubMed1997

Admission prediction of expected final myocardial infarct size using weighted ST-segment, Q wave, and T wave measurements.

Formulas for predicting final acute myocardial infarction (MI) size from ST-segment deviation on an initial electrocardiogram were proposed by Aldrich et al. for anterior and inferior infarct locations. This study of 529 patients who did not receive thrombolytic therapy was performed to determine the effectiveness of the Aldrich formulas for predicting final QRS MI size; to propose new formulas for predicting final MI size using ST-segment deviation, Q wave, and T wave information in a development population of 322 patients; and to evaluate the new formulas in a randomly selected population of 207 patients. The Aldrich formulas achieved correlations with final infarct size of r = .40 for anterior and r = .43 for inferior MI locations in the present population which are weaker than those previously reported. Formulas that consider electrocardiographic parameters in addition to ST-segment deviation were proposed for both anterior and inferior final MI size. In the test set of 207 patients, these models explained 16.9% and 15.2% of the variation in final MI size for anterior and inferior locations respectively. They may prove useful in assessing the extent of myocardial salvage where interventions are to be tested.

Electrocardiography↗
PubMed1997

Undergraduate students' perceptions of child sexual abuse: effects of age, sex, and gender-role attitudes.

OBJECTIVE: The present study examined how sex of the child and the adult and age of the child influence perceptions regarding the abusiveness of adult-child sexual interactions and attributions of blame and responsibility to the adult in such incidents. The relationship of gender-role attitudes to perceptions of child sexual abuse was also investigated. METHOD: Undergraduate students (N = 404) read one of eight vignettes depicting a sexual interaction between a child and an adult in which sex of the child, age of the child, and sex of the adult were manipulated. Respondents then answered questions regarding their perceptions of the abusiveness of the incident and attributions of responsibility and blame to the adult. RESULTS: Scenarios depicting a 15-year-old were rated as less abusive, and less responsibility was attributed to the adult, relative to vignettes involving a 7-year-old. Respondents also rated scenarios depicting opposite-sex interactions as less abusive relative to scenarios describing same-sex interactions. When vignettes depicted a 15-year-old, less blame was attributed to the adult relative to when vignettes depicted a 7-year-old with an adult of either sex, with the least amount of blame being attributed to the adult involved with an adolescent of the opposite-sex. Gender-role attitudes were not significantly related to ratings of abusiveness or attributions of responsibility and blame. CONCLUSIONS: These findings suggest that age of the child may influence ratings of abusiveness and attributions of responsibility and blame. Ratings of abusiveness and attributions of blame also appear to be influenced by the sex pairing in the interaction.

Adolescent↗
PubMed1997

Causes of chest pain and symptoms suggestive of acute cardiac ischemia in African-American patients presenting to the emergency department: a multicenter study.

This study examines whether race is a significant determinant of the diagnoses of acute myocardial infarction or angina pectoris in patients with symptoms suggestive of acute cardiac ischemia. The study population was comprised of 3401 (34%) African-American and 6600 (66%) white patients who presented to emergency departments with symptoms suggestive of acute cardiac ischemia. The main outcome measure was a diagnosis of acute myocardial infarction or angina pectoris. African Americans were younger, predominantly female, and more often had hypertension, diabetes mellitus, or smoked. The diagnosis of acute myocardial infarction was confirmed in 6% of African-American and 12% of white men, and in 4% of African-American and 8% of white women. After adjusting for age, gender, medical history, signs and symptoms, and hospital, African Americans were half as likely to develop acute myocardial infarction and were 60% as likely to have acute cardiac ischemia. Despite having less acute cardiac ischemia, African Americans in this study had high risk levels for coronary artery disease.

Acute Disease↗
PubMed1996

Characteristics, management, and outcome of patients with acute myocardial infarction treated with bypass surgery. Myocardial Infarction Triage and Intervention Investigators.

BACKGROUND: Although multiple studies have addressed the efficacy of bypass surgery in patients with stable angina, there are relatively few studies that have evaluated the optimal timing, risk of hospital mortality, and long-term outcome for patients with bypass surgery performed in the setting of acute infarction. METHODS AND RESULTS: With data collected from all admitted patients with acute myocardial infarction to 19 Seattle-area hospitals between 1988 and 1994, we studied the characteristics, hospital course, and long-term outcome in 1299 patients who underwent bypass surgery. There was no difference in hospital mortality in patients operated on during the first 24 hours after admission compared with those operated on later in the hospital course (8.3% versus 7.2%; P=.60). Factors that predicted hospital mortality in those who underwent bypass surgery included increased age, prior bypass surgery, infarct extension, and stroke. Long-term outcome in those who underwent bypass surgery was excellent, with low rates of subsequent coronary angiography (7.4% at 3 years) and coronary angioplasty (2.6% at 3 years). Three-year survival was better in bypass recipients than in those treated medically (83% versus 66%; P < .0001), and this difference remained after multivariate adjustment for baseline differences (hazard ratio, 0.68; 95% CI, 0.55 to 0.85). CONCLUSIONS: Patients can be safely operated on early in the course of acute infarction, risk factors for hospital mortality are not substantially different from factors identified in the noninfarct setting, and bypass surgery in select patients after acute infarction is associated with low repeat procedure use and excellent long-term survival.

Adult↗
PubMed1996

Influence of sex on the use of cardiac procedures in patients presenting to the emergency department. A prospective multicenter study.

BACKGROUND: Reports about the use of cardiac procedures have produced conflicting results as to whether there is a sex bias in the use of thrombolytic therapy, cardiac catheterization, or revascularization procedures. The present study was undertaken with the hope of resolving some of these different findings by examining the use of these therapies in women and men who presented to the emergency department with symptoms suggestive of acute cardiac ischemia. METHODS AND RESULTS: During 7 consecutive months in 1993, 10673 individuals > or = 30 years old who presented with chest pain or other symptoms suggestive of acute cardiac ischemia were enrolled in the Acute Cardiac Ischemia Time-Insensitive Predictive Instrument Clinical Trial at 10 hospitals in the East and Midwest. This study included 2542 patients (24% of all patients) who had confirmed acute myocardial infarction or angina pectoris. There were significant sex differences with respect to demographic and clinical characteristics and the use of cardiac procedures. Among patients with acute myocardial infarction, the use of thrombolytic therapy, cardiac catheterization, and revascularization procedures was similar in women and men after multivariate adjustment. However, in the group with angina pectoris, women were considerably less likely to undergo these procedures, even after adjustment for significant baseline covariates. CONCLUSIONS: Women with angina pectoris were less likely to undergo cardiac catheterization or revascularization procedures, although unmeasured factors could in part explain the observed differences.

Adult↗
PubMed1996

Influence of early prehospital thrombolysis on mortality and event-free survival (the Myocardial Infarction Triage and Intervention [MITI] Randomized Trial). MITI Project Investigators.

The Myocardial Infarction Triage and Intervention Trial of prehospital versus hospital administration of thrombolytic therapy markedly reduced hospital treatment times, but the 2 groups had similar outcomes. However, patients treated < 70 minutes from symptom onset had better short-term outcomes. The purpose of this study was to determine the long-term influence of very early thrombolytic treatment for acute myocardial infarction. A total of 360 patients were followed for vital status and cardiac-related hospital admissions over a period of 34 +/- 16 months. Patients enrolled in the trial had symptoms for < or = 6 hours, ST-segment elevation on the prehospital electrocardiogram, and no risk factors for serious bleeding. They received aspirin and recombinant tissue plasminogen activator either before or after hospital arrival. Primary end points in this study included long-term survival and survival free of death or readmission to the hospital for angina, myocardial infarction, congestive heart failure, or revascularization. Two-year survival was 89% for prehospital- and 91% for hospital-treated patients (p = 0.46). Event-free survival at 2 years was 56% and 64% for prehospital- and hospital-treated patients, respectively (p = 0.42). In patients treated < 70 minutes from symptom onset, 2-year survival was 98%, and it was 88% for those treated later (p = 0.12). Two-year event-free survival was 65% for patients treated early and 59% for patients treated later (p = 0.80). In this trial, poorer long-term survival was associated with advanced age, history of congestive heart failure, and coronary artery bypass surgery performed before the index hospitalization, but not with time to treatment.

Aged↗
PubMed1996

Comparison of presentation, treatment, and outcome of acute myocardial infarction in men versus women (the Myocardial Infarction Triage and Intervention Registry)

This study compared the presentation (symptoms and signs), treatment, and outcome of 1,097 consecutive patients (851 men and 246 women) from the Myocardial Infarction Triage and Intervention (MITI) Project Registry with confirmed acute myocardial infarction (AMI), all of whom were initially evaluated in the prehospital setting, met clinical criteria for possible thrombolysis, and were followed throughout their hospital course. Women were older than men and had a higher prevalence of known cardiovascular risk factors, including systemic hypertension and congestive heart failure. The presentation of AMI with respect to symptoms, delay, and hemodynamic and electrocardiographic findings was for the most part indistinguishable between mean and women. Women appeared "undertreated" early in the course of AMI and were half as likely as men to undergo acute catheterization, angioplasty, thrombolysis, or coronary bypass surgery (odds ratio 0.5 [0.3 to 0.7]). The risk for hospital mortality in women was almost twice that for men (odds ratio 1.95 [1.01 to 3.8]). Hospital mortality after AMI was also independently predicted by older age, early evidence of hemodynamic instability, and an intraventricular conduction abnormality on the initial electrocardiogram. Although similar in its presentation, AMI in women is not as aggressively treated, and results in a less favorable outcome than in men. Gender as well as nongender-specific risk factors are important in assessing risk and the likelihood of early intervention after AMI.

Aged↗
PubMed1996

Relation between symptom duration before thrombolytic therapy and final myocardial infarct size.

BACKGROUND: Myocardial salvage is most likely to occur when thrombolytic therapy is administered within 4 to 6 hours of the onset of symptoms of myocardial infarction. The impact of delays within this early time period on final myocardial infarct size are unknown. The purpose of this study was to quantitate the relation between final myocardial infarct size and duration of symptoms before initiation of thrombolytic therapy in patients treated within 6 hours of symptom onset. METHODS AND RESULTS: The findings from patients in four prospective randomized trials of thrombolytic therapy were combined for analysis. The study population consisted of 432 patients presenting within 6 hours of onset of symptoms of first acute myocardial infarction who met ECG criteria that allowed estimation of myocardial area at risk before treatment with thrombolytic therapy and who had thallium-201 myocardial infarct-size measurements performed several weeks after infarction. ECG analysis revealed no difference in myocardium at risk for infarction as a function of duration of symptoms before initiation of thrombolytic therapy. In contrast, univariate and multivariate analysis showed that final infarct size was highly dependent on duration of symptoms before initiation of therapy. Each 30-minute increase in symptom duration before thrombolytic therapy was associated with an increase in infarct size of 1% of the myocardium. Final infarct size in patients treated 4 to 6 hours after symptom onset was indistinguishable from patients who did not receive thrombolytic therapy. CONCLUSIONS: These findings suggest that for patients treated within 4 to 6 hours of the onset of symptoms, there is a progressive decline in the extent of myocardium salvaged as the duration of symptoms before therapy increases. These results support efforts to minimize the time delay between symptom onset and initiation of reperfusion therapy in all eligible patients.

Adult↗
PubMed1996

Managing care, incentives, and information: an exploratory look inside the "black box" of hospital efficiency.

OBJECTIVE: We sought to estimate the impact of individual dimensions of hospitals' managed care strategies on the cost per hospital discharge. STUDY SETTING/DATA SOURCES: Thirty-seven member hospitals of seven health systems in the Pacific, Rocky Mountain, and Southwest regions of the United States were studied. STUDY DESIGN: Separate cross-sectional regression analyses of 21,135 inpatient discharges were performed in 1991 and 23,262 discharges in 1992. The multivariate model was estimated with hospital cost per discharge as the dependent variable. Model robustness was checked by comparing regression results at the individual discharge level with those at the level of the hospital/clinical condition pair. DATA COLLECTION/EXTRACTION METHODS: Information on hospitals' managed care strategies was provided by mail and phone survey of key informants in 1991 and 1992. Other hospital characteristics were collected from AHA Annual Survey data, and discharge data from hospital abstracting systems. PRINCIPAL FINDINGS: The pooled discharge analysis indicated three dimensions of hospital managed care strategy that consistently related to lower costs per hospital discharge: the proportion of hospital revenues derived from per case or capitation payment, the hospital's mechanisms for sharing information on resource consumption with clinicians, and the use of formalized, systematic care coordination mechanisms. CONCLUSIONS: Three strategies appear to hold promise for enhancing the efficiency of inpatient resource use: (1) "fixed price" hospital payment incentives, (2) hospital approaches to sharing resource use information with clinicians, and (3) the application of formal care management mechanisms for specific clinical conditions.

Aged↗
PubMed1995

Factors influencing the time to administration of thrombolytic therapy with recombinant tissue plasminogen activator (data from the National Registry of Myocardial Infarction). Participants in the National Registry of Myocardial Infarction.

Very early administration of thrombolytic therapy for acute myocardial infarction (AMI) has significantly reduced mortality in eligible patients. The purpose of this study was to evaluate factors which influenced the time from symptom onset to hospital presentation and the time from hospital presentation to the onset of thrombolytic treatment in a large population of patients with AMI. This study included 212,990 patients from 904 hospitals that participated in the National Registry of Myocardial Infarction. The median time from symptom onset to hospital presentation for those treated was 1.5 hours versus 2.7 hours for those not receiving thrombolytic treatment. Older patients and women had increased delay times, as did those who arrived at the hospital during daytime hours. Of the 59,802 (28%) patients who received thrombolytic treatment, 23% were treated < 30 minutes from admission; 63%, < 60 minutes; and 83%, < 90 minutes. Time to treatment increased with age and was longer for women and for patients arriving between midnight and early morning. The most important factor associated with shorter time to treatment was the initiation of thrombolytic treatment in the emergency department rather than in the coronary care unit (47 vs 73 minutes, p < 0.0001). Hospital treatment times are much too long, given that quick identification and treatment of eligible patients are of primary importance in reducing mortality from AMI. To shorten these times, thrombolytic treatment should be initiated in the emergency department, and the effectiveness of hospital programs aimed at reducing time to treatment should be subject to continuing quality improvement surveillance.

Aged↗
PubMed1995

Changes in the Use of Thrombolytic Therapy in Seattle Area Hospitals from 1988 to 1992: Results from the Myocardial Infarction Triage and Intervention Registry.

Background: Thrombolytic therapy has been shown to reduce mortality in select patients with acute myocardial infarction (AMI). The determinants of eligibility for therapy are changing as more information about the safety and efficacy of thrombolytic therapy is obtained. In the United States, there is some concern that thrombolytic therapy is underutilized, particularly in women and older patients. The purpose of this investigation is to examine change in the use of thrombolytic therapy in a single community from the years 1988 to 1992. Particular attention was paid to women and older patients. Methods: From January 1988 through December 1992, 9154 patients who developed AMI were admitted to coronary care units in 19 hospitals in the metropolitan Seattle area. The hospital records of each consecutive patient were reviewed, and key information was entered into the Myocardial Infarction Triage and Intervention database. Patients who developed AMI after hospital admission for another medical condition were excluded, as were the small numbers of patients with AMI complicated by cardiac arrest and resuscitation prior to hospital admission. This population-based study contains first admissions for AMI during the 5 year period of the registry. Results: The use of thrombolytic therapy in all patients increased from 18% to 24% (p <.0001) during the 5 year period; women (10-16%) and patients 75 years and older (3-10%) had proportionately greater increases in utilization. Despite widespread awareness of its importance, the median time from symptom onset to hospital arrival did not change during the 5 years, although there was a slight decrease in the time from hospital arrival to treatment with thrombolytic therapy. Conclusions: The change in use of thrombolytic therapy indicates that age and gender are less often used as exclusions for receiving thrombolytic therapy. It is possible that exclusionary criteria are being modified, with the result that this important treatment is being received by more people. The finding that there was no change in the time from acute symptom onset to hospital arrival requires intensive study. In particular, more needs to be known about patient decisionmaking, and innovative community interventions to reduce delay times must be evaluated.

Journal Article↗
PubMed1995

Appearance of abnormal Q waves early in the course of acute myocardial infarction: implications for efficacy of thrombolytic therapy.

OBJECTIVES: The purpose of this study was to determine the time course of the appearance of abnormal Q waves on the electrocardiogram (ECG) over the first 6 h of symptoms of myocardial infarction and to determine what implications, if any, such Q waves have for the efficacy of thrombolytic therapy. BACKGROUND: Severe myocardial ischemia can produce early QRS changes in the absence of infarction. Abnormal Q waves on the baseline ECG may not be an accurate marker of irreversibly injured myocardium. METHODS: Data from 695 patients who had no past history of myocardial infarction and whose admission ECG allowed prediction of myocardial infarct size in the absence of thrombolytic therapy (Aldrich score) were pooled from four prospective trials of thrombolytic therapy. The presence and number of abnormal Q waves on each patient's initial ECG were recorded. Four hundred thirty-six patients had left ventricular infarct size measured using quantitative thallium-201 tomography a mean (+/- SD) of 52 +/- 43 days after admission. RESULTS: Of patients admitted within 1 h of symptoms, 53% had abnormal Q waves on the initial ECG. Both predicted and final infarct size were larger in patients with abnormal Q waves on the initial ECG independent of the duration of symptoms before therapy (p < 0.001). Despite this finding, the presence of abnormal Q waves on the admission ECG did not eliminate the effect of thrombolytic therapy on reducing final infarct size (p < 0.0001). CONCLUSIONS: Abnormal Q waves are a common finding early in the course of acute myocardial infarction. However, there is no evidence that abnormal Q waves are associated with less benefit in terms of reduction of infarct size after thrombolytic therapy.

Electrocardiography↗