Biomedical subjects

C Mechem

Publications and source records attributed to C Mechem.

6 recordsLinked to original sources

PubMed1996

Determination of angiographic (TIMI grade) blood flow by intracoronary Doppler flow velocity during acute myocardial infarction.

BACKGROUND: This study compared angiographically graded coronary blood flow with intracoronary Doppler flow velocity in patients during percutaneous transluminal coronary angioplasty (PTCA) for acute myocardial infarction. Different TIMI angiographic flow grades (flow grades based on results of the Thrombolysis in Myocardial Infarction trial) have been associated with different clinical results after reperfusion for acute myocardial infarction. However, intracoronary blood flow velocity has not been compared with the angiographic method of determining flow grade in patients. METHODS AND RESULTS: Coronary flow velocity (measured by use of a Doppler guidewire) during primary or rescue PTCA in 41 acute myocardial infarction patients was compared with TIMI grade and cineframes-to-opacification count. Before PTCA, 34 patients had TIMI grade 0 or 1, 5 had TIMI grade 2, and 2 had TIMI grade 3 flow in the infarct artery. Flow velocity was similar among patients with TIMI grades 0, 1, or 2 but was lower than in those with TIMI grade 3 flow (9.4 +/- 5.4 versus 16.0 +/- 5.4 cm/s for TIMI grades < or = 2 versus TIMI grade 3, respectively; P < .05). After PTCA, 1 patient had TIMI grade 1, 5 had TIMI 2, and 35 had TIMI 3 flow. Poststenotic flow velocity increased from 6.6 +/- 6.1 to 20.0 +/- 11.1 cm/s (P < .01). TIMI grade 3 flow increased to 21.8 +/- 10.9 cm/s (P < .05 versus before PTCA). Although post-PTCA flow velocity correlated with angiographic cineframes-to-opacification count (r = .45; P < .02) for TIMI grade 3, there was a large overlap with TIMI grades < or = 2 that had low flow velocity (< 20 cm/s). Nine of 11 clinical events (unstable angina and coronary artery bypass graft surgery) occurred in patients with low coronary flow velocity. CONCLUSIONS: Determination of flow velocity after reperfusion may enhance patient characterization and provide the physiological rationale for clinical variations after reperfusion therapy.

Adult↗

PubMed1996

Periprocedural Doppler coronary blood flow predictors of myocardial perfusion abnormalities and cardiac events after successful coronary interventions.

Thirty-four consecutive patients had coronary flow velocity assessed under basal and hyperemic conditions in the proximal and distal coronary artery, followed by rest-stress technetium 99m sestamibi myocardial tomography within 3 months of successful coronary angioplasty. In spite of significant angiographic improvement, 29% of patients had a persistent reversible myocardial perfusion defect associated with a residual abnormality of the proximal-to-distal coronary average peak velocity ratio (p/d APV = 2.2 +/- 1.5 vs 1.1 +/- 0.6; p = 0.02). Patients with an abnormal p/d APV ratio (>1.7) had more numerous angioplasty-zone perfusion defects (4.2 +/- 3.3 vs 0.8 +/- 2.0; p = 0.005). Multivariable analysis of clinical, angiographic, coronary flow, and scintigraphic data demonstrated that the relative risk of cardiac events (n = 11) was greatest in patients with a reversible angioplasty-zone perfusion defect (relative risk, 5.5), poststenotic coronary flow reserve <2.0 (relative risk, 8.3) and p/d APV ratio >1.7 (relative risk, 6.2). Residual basal coronary flow-velocity abnormalities are significant physiologic correlates of stress-induced myocardial perfusion defects and are a prognostic covariable associated with future ischemic cardiac events.

Adult↗

PubMed1996

Influence of percutaneous transluminal coronary rotational atherectomy with adjunctive percutaneous transluminal coronary angioplasty on coronary blood flow.

The purpose of this study was to examine the influence of sequential percutaneous transluminal coronary rotational atherectomy (PTCRA) and coronary angioplasty on coronary blood flow reserve in patients. Rotational coronary atherectomy restores lumen patency by partially ablating fibrocalcific plaque, releasing microparticulate debris into the distal coronary circulation. Adjunctive balloon angioplasty is usually performed to optimize the angiographic luminal dimensions. Serial alterations in coronary physiology have not been reported. Fourteen lesions in 13 patients were treated by sequential rotational atherectomy followed by adjunctive balloon angioplasty. Poststenotic baseline coronary blood flow velocity was measured by using a Doppler flow wire (FloWire, Cardiometrics, Inc., Mountain View, Calif.), and coronary blood flow was calculated by using the distal vessel cross-sectional area obtained by quantitative coronary angiography. Data were acquired at baseline and during hyperemia (12 to 18 microg of intracoronary adenosine), before and after PTCRA, and again after balloon angioplasty. The mean stenosis decreased from 76 percent +/- 12 percent at baseline to 21 percent +/- 11 percent at the completion of the procedure (p<0.01). The minimal luminal diameter (by quantitative coronary angiography) was 0.7 +/- 0.4 mm at baseline, increased to 1.9 +/- 0.4 mm after rotational atherectomy (p<0.01), and increased to 2.4 +/- 0.5 mm after balloon angioplasty (p<0.01 versus baseline and PTCRA). Distal (poststenotic) coronary blood flow at baseline was 47 +/- 23 ml/min and 57 +/- 38 ml/min during hyperemia. After PTCRA, coronary blood flow increased to 104 +/- 59 ml/min and to 132 +/- 73 ml/min with hyperemia. After adjunctive angioplasty, coronary blood flow was 84 +/- 40 ml/min (p=not significant [NS] vs PTCRA) and increased to 143 +/- 81 ml/min with hyperemia (p=NS vs PTCRA). The poststenotic coronary flow reserve increased from an initial value of 1.1 +/- 0.2 ml/min to 1.3 +/- 0.3 ml/min after PTCRA (p=NS vs baseline) and to 1.6 +/- 0.3 ml/min after adjunctive balloon angioplasty (p<0.01 vs p=NS vs PTCRA). PTCRA significantly increased resting coronary blood flow. Adjunctive balloon angioplasty did not significantly augment resting or hyperemic coronary blood flow more than that achieved by rotational atherectomy alone. These data demonstrate that PTCRA alone improves baseline coronary blood flow with minimal additional physiologic change after adjunctive balloon angioplasty.

Aged↗

PubMed1994

Improved left ventriculography with the new 5F helical-tip Halo catheter.

The purpose of this study was to evaluate the incidence of ventricular ectopy and catheter movement during left ventriculography with a new 5F halo angiographic catheter that has a unique helical-tip design unlike the design of standard 5F and 6F pigtail catheters. The pigtail catheter is presently preferred for left ventriculography, although its use is associated with a high incidence of ventricular ectopy, which often limits precise interpretation of data. In this study, 155 patients (in 145 unpaired and 10 paired studies) underwent left ventriculography during diagnostic cardiac catheterization. In the unpaired group, the 5F Halo catheter was used in 63 studies and standard 5F and 6F pigtail catheters in 40 and 42 studies, respectively. An additional 10 patients had two consecutive left ventriculograms with 5F Halo and pigtail catheters. Ventriculograms were performed with the same technique in the 30-degree right anterior oblique projection. The left ventricle was divided into a basal zone, midzone, and apical zone. Catheter movement within the ventricle was scored as significant if there was at least one zone change. Ventricular ectopy was quantified by a simultaneous electrocardiographic recording during contrast injection. There were no significant differences in the left ventricular systolic or end-diastolic pressures, left ventricular score, or diagnostic quality of the ventriculograms between the 5F Halo catheter group and the 5F and 6F pigtail catheter groups. Mean ventricular ectopy with the 5F Halo catheter was significantly less (0.9 +/- 1.4 ventricular premature beats [VPBs]) than with the 5F pigtail catheter (2.3 +/- 2.5 VPBs, p < 0.001) or the 6F pigtail catheter (2.9 +/- 2.9 VPBs, p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

PubMed1994

Wound botulism.

Wound botulism is a rare infectious and toxicologic complication of trauma and i.v. drug abuse. Only 39 cases have been reported in detail in the English literature. This case report describes a patient with wound botulism who presented to four medical facilities before receiving definitive diagnosis and treatment. Although his history and physical examination were consistent with wound botulism, diagnosis and therapy were delayed because this rare disease was not considered initially in the differential diagnosis. Wound botulism should be considered in trauma patients and i.v. drug abusers who present with cranial nerve palsies and descending paresis.

Abscess↗

PubMed1989

Intravital fluorescence microscopy of endothelial cells on vascular grafts.

The ability to evaluate the extent of initial endothelial cell coverage on a vascular graft subsequent to an endothelial cell seeding technique would be desirable to substantiate the durability of the endothelial cell lining. To this end, we have evaluated the use of intravital fluorescence microscopy to assess human endothelial cell interaction with vascular grafts. Five fluorescent stains, mithramycin, Hoechst 33342, sulfofluorescein diacetate, Nile red, and rhodamine 123 were evaluated for their ability to fluorescently label human endothelial cells. The staining capability of each dye was also evaluated with respect to accuracy in determining seeded cell number and cell spreading. Of the stains evaluated, rhodamine 123 produced the most desirable characteristics. We observed excellent cell visualization after a 30-min incubation. Unlike the other four stains, rhodamine 123 exhibited a bright orange fluorescence emission at a 510-nm excitation wavelength while the underlying dacron or expanded polytetrafluoroethylene demonstrated minimal autofluorescence. Rhodamine 123 also exhibited no inhibitory effect on cell attachment to plastic or subsequent cell growth in culture. Intravital fluorescence microscopy could be easily utilized in the operating room to visualize part or all of an endothelial cell-seeded graft prior to implantation and would permit a quantitative as well as qualitative evaluation of the seeding process. Since intravital fluorescence imaging does not require tissue fixation, the same surface as that evaluated for seeding efficiency can be directly implanted.

Blood Vessels↗