PubMed Health⌕ Search

Biomedical subjects

C Medrano

Publications and source records attributed to C Medrano.

14 recordsLinked to original sources
PubMed2000

Thoracoscopic resection of ectopic parathyroid glands.

BACKGROUND: The vast majority of parathyroid glands in hyperparathyroidism can be resected through a cervical approach. In approximately 2% of the cases, the ectopic gland is in the mediastinum in a location that requires a thoracic approach. METHODS: We report 7 such cases that were resected using video-assisted thoracic surgery to avoid the need for an open surgical procedure. RESULTS: All glands were successfully identified preoperatively and subsequently resected. Hospital stay averaged less than 3 days with only one minor complication. CONCLUSIONS: Ectopic mediastinal parathyroid glands may be safely and accurately resected using video-assisted thoracic surgery to avoid open approaches.

Adenoma↗
PubMed2000

Vertebral osteomyelitis due to Pasteurella aerogenes.

A case of C6-C7 vertebral osteomyelitis due to Pasteurella aerogenes in a previously healthy 62-y-old man in the absence of any history of animal exposure, debilitating disease or immunosuppression is reported. Culture testing of biopsy samples of the vertebral body using the panels and database of the BBL Crystal enteric/non-fermenter system revealed that the infecting bacterium was P. aerogenes. Treatment with cloxacillin and gentamicin was followed by resolution of bone infection on serial follow-up magnetic resonance imaging scans. Pasteurellae are primarily animal pathogens but are capable of producing a variety of local and systemic diseases in humans.

Cervical Vertebrae↗
PubMed1999

[Hemodynamic changes during laparoscopic surgery. Preliminary study].

The haemodynamic changes produced by laparoscopic surgery in children have been evaluated. A transesophageal echocardiographic study on 13 patients (7 males and 6 females, 10.8 +/- 2.7 years old) has been performed before, during and after peritoneal CO2 gas insufflation. A change on the Doppler waves pattern of the infradiaphragmatic veins along with an increase in blood flow velocity were observed. Pulmonary veins suffered minimal changes showing an increase on either the systolic pressure and on atrial contraction. Diastolic retrograde flow in aorta reflected an increase in peripheral vascular resistance. Cardiac output increased minimally. All haemodynamic changes returned to basal after gas peritoneal desufflation. These data show that laparoscopic surgery could produce important cardiac derangements in children with ventricular dysfunction or in patients presenting left ventricular outlet obstruction. In these patients laparoscopic surgery might be precluded.

Abdominal Pain↗
PubMed1996

Sequential granulocyte colony-stimulating factor increases cisplatin cytotoxicity in human epithelial ovarian cancer cell lines.

BACKGROUND: To determine the effect of granulocyte colony-stimulating factor (G-CSF) on tumor growth and cisplatin cytotoxicity in human epithelial ovarian cancer. METHODS: Six human epithelial ovarian cancer cell lines were treated with media (control) for 24 hr, G-CSF for 24 hr, cisplatin for 24 hr, simultaneous cisplatin and G-CSF for 24 hr, media (control) for 48 hr, cisplatin for 24 hr and sequential media for 24 hr, cisplatin for 24 hr, and sequential G-CSF for 24 hr. Following incubation, the percentage cell lysis was determined by particle concentration fluorescein immunoassay chemosensitivity assay. RESULTS: G-CSF resulted in tumor cell growth (7-19%) in three cell lines. Simultaneous G-CSF decreased cisplatin cytotoxicity in five cell lines (7-45%). Sequential G-CSF increased cisplatin cytotoxicity in all six cell lines (5-108%). CONCLUSIONS: G-CSF may result in ovarian cancer proliferation. Simultaneous G-CSF may decrease cisplatin cytotoxicity, while sequential G-CSF appears to increase cisplatin cytotoxicity.

Cell Division↗
PubMed1989

Onchocerciasis endemic in the State of Bolivar, Venezuela.

Microfilariae of Onchocerca volvulus were demonstrated by single shoulder-skin biopsy in 42.8% of inhabitants of seven Amerindian villages in an area of approximately 10,000 km2, near the Brasilian Roraima Territory. The highest prevalence was found among the Yanomama Indians of Chajuraña (84.6%, with a mean of 61.3 microfilariae per mg of skin). The six other communities were affected, but with lower prevalence and microfilaria skin densities. The absence of lymphoedema and the few subcutaneous nodules and eye lesions found among the infected individuals suggest a relatively recent introduction of the disease to the region. Mansonella ozzardi infections were also detected in the area.

Adult↗
PubMed1982

Chromosome translocations in couples with multiple spontaneous abortions.

The reported incidence of balanced chromosomal translocations in couples with multiple spontaneous abortions (SABs) ranges from 0% of 31%. Because our experience has suggested that SABs are useful for ascertaining balanced translocations, we report the results of chromosome analyses performed on blood specimens from 440 individuals including 200 couples who were ascertained on the basis of two or more SABs. Balanced translocations were found in 3.6% of these 200 couples. For 122 of these couples, more detailed reproductive histories were available. For 48 couples with two SABs, four (8.4%) had balanced translocations; for 37 couples with three SABs, one (2.7%) had a balanced translocation; for 20 couples with four SABs, two (10%) had balanced translocations; and for 17 couples with five or more SABs, one (5.9%) had a balanced translocation. These 122 couples could also be classified on the basis of having abnormal or healthy children. For 40 couples with two or more SABs, one or more healthy children, and no abnormal offspring, two (5.0%) had balanced translocations; for 20 couples with two or more SABs and one or more abnormal children (and in some cases one or more healthy children), one (5.0%) had a balanced translocation; for 62 couples with two or more SABs and no other pregnancies, four (6.5%) had balanced translocations.

Abortion, Habitual↗
PubMedDate not supplied

Towards the physical map of the Trypanosoma cruzi nuclear genome: construction of YAC and BAC libraries of the reference clone T. cruzi CL-Brener.

Strategies to construct the physical map of the Trypanosoma cruzi nuclear genome have to capitalize on three main advantages of the parasite genome, namely (a) its small size, (b) the fact that all chromosomes can be defined, and many of them can be isolated by pulse field gel electrophoresis, and (c) the fact that simple Southern blots of electrophoretic karyotypes can be used to map sequence tagged sites and expressed sequence tags to chromosomal bands. A major drawback to cope with is the complexity of T. cruzi genetics, that hinders the construction of a comprehensive genetic map. As a first step towards physical mapping, we report the construction and partial characterization of a T. cruzi CL-Brener genomic library in yeast artificial chromosomes (YACs) that consists of 2,770 individual YACs with a mean insert size of 365 kb encompassing around 10 genomic equivalents. Two libraries in bacterial artificial chromosomes (BACs) have been constructed, BACI and BACII. Both libraries represent about three genome equivalents. A third BAC library (BAC III) is being constructed. YACs and BACs are invaluable tools for physical mapping. More generally, they have to be considered as a common resource for research in Chagas disease.

Animals↗