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Biomedical subjects

C Mejersjö

Publications and source records attributed to C Mejersjö.

12 recordsLinked to original sources
PubMed1991

Dental needs of patients with myotonic dystrophy.

The aim of this study was to assess oral health and motoric ability in persons with myotonic dystrophy in comparison with a control group of healthy persons and find out whether an increased need of dental care exists in persons with reduced motoric ability. Twenty-seven persons, mean age 45, with the diagnosis myotonic dystrophy were compared with an age- and sex-matched control group. The dental status was determined from orthopantomograms and bite-wing radiographs. Oral hygiene, using a simplified index, periodontal pocket depth and alveolar bone height were recorded. Additionally, the finger force of the patient was recorded in order to evaluate the muscular capacity. Compared to control persons, persons with myotonic dystrophy had a lower finger force. They also had fewer teeth, higher caries frequency and more plaque, although no difference was found in the alveolar bone support around their remaining teeth. A positive correlation was found between finger force and oral hygiene. Persons with myotonic dystrophy had a decreased ability to maintain good oral hygiene, possibly due to motoric disability, and they had an increased need of dental hygienic care.

Adult↗
PubMed1989

Muscle function and craniofacial morphology: a clinical study in patients with myotonic dystrophy.

The occlusal traits and the craniofacial morphology were studied in patients with an altered muscle function caused by myotonic dystrophy. Twenty-four adult patients were examined and compared with a matched group of healthy individuals. The condition of the masticatory muscles was evaluated by measuring the maximal bite force. The dental arches and the occlusal traits were analysed on dental casts. Lateral cephalograms were taken in the patients with myotonic dystrophy to study the craniofacial morphology. It was found that the patients suffering from myotonic dystrophy had weak masticatory muscles, which might be caused by the disease. A high prevalence of malocclusions (postnormal occlusion, anterior open bite and lateral cross bite) was found among these patients. Their craniofacial morphology showed a vertical aberration, characterized by a large angle between the mandibular and palatal planes and a steep mandible. These findings seem to be most pronounced in patients with an early onset of the disease and support the hypothesis that reduced muscle function may cause changes in the craniofacial morphology.

Adult↗
PubMed1987

Effect of corticosteroid and sodium hyaluronate on induced joint lesions in the guinea-pig knee.

50 guinea-pigs had lesions induced in their knee-joints by intra-articular injections of papain solution (2%). The lesions developed were treated with intra-articular injections of corticosteroid (Celestona bifas) in the right and sodium hyaluronate (Hylartil) in the left knee. The treatment was repeated after 1 week. 5 months later, the joints were examined macroscopically, microscopically and radiographically. Comparison of the effects of treatment showed that early treatment with hyaluronate resulted in less deviation in form of the joint, and less granulation tissue formation but no significant difference in the overall severity of the lesions was found. Granulation tissue, fibrotic adhesions and inflammation in the synovial membrane induced in the experimental model were positively correlated to cortical bone destruction.

Animals↗
PubMed1984

Analysis of factors influencing the long-term effect of treatment of TMJ-pain dysfunction.

A follow-up study on 154 females was performed approximately 7 years after the start of treatment for TMJ pain dysfunction. At the follow-up the function of the patients' masticatory system had on average greatly improved. The individual variation was great, however. In this paper the influence of such factors as diagnosis, age, general health, occlusal disharmonies, dentition and social environment on the long-term effect of treatment was analysed. Patients with TMJ osteoarthrosis had, on average, no more signs or symptoms of dysfunction at the follow-up than those judged to have had mainly neuromuscular problems. Poor general health was found to have a negative influence both on the immediate response to treatment of TMJ pain dysfunction and on the long-term prognosis. Few correlations were found between occlusal factors and dysfunction. Occlusal interferences showed no correlation to dysfunction at the first examination and at the follow-up were mainly correlated to some reported symptoms. Loss of molars and premolars was correlated to impaired TMJ-function. The patients with repeated periods of treatment (14%) did not differ from the rest with respect to signs and symptoms of dysfunction at the follow-up. In eight patients with extremely long periods of treatment general health problems and/or psychosocial factors were evident.

Adolescent↗
PubMed1984

TMJ pain and dysfunction: relation between clinical and radiographic findings in the short and long-term.

Clinical examination of the stomatognathic system and radiographic examination of the temporomandibular joints (TMJ), including the submentovertical, the oblique lateral transcranial and the transmaxillary projections, were performed in 104 patients with TMJ pain/dysfunction. Seven years later these patients had a new clinical examination and 54 of them were radiographed again. Another 20 patients not primarily radiographed were also recalled after 7 yr and examined clinically and radiographically. The radiographic findings were correlated with the reported symptoms and clinical findings. Only a few statistically significant correlations were found. The initial clinical dysfunction, estimated with the aid of the Helkimo dysfunction index, was positively correlated with the radiographic findings at the follow-up. The most important clinical variables in this respect were tenderness to palpation of the joint and decreased mobility. Crepitation was associated with changes in the structure and shape of the condyle. Clicking was correlated with a posterior displacement of the condyle. The number of occluding pairs of teeth was related to changes in the TMJ structure and shape also when age was considered as a confounding factor. Radiographic changes of the TMJ develop late and are often absent in the acute phase. An early radiographic examination is therefore of less diagnostic importance in this respect, but serves the purpose of excluding other pathologic conditions.

Adolescent↗
PubMed1984

Radiography of the temporomandibular joint in female patients with TMJ pain or dysfunction. A seven year follow-up.

One hundred and twenty-four patients with temporomandibular joint (TMJ) pain/dysfunction were examined radiographically and 54 of these patients were reexamined at a follow-up approximately after 7 years. The radiographic examination included submentovertical, oblique lateral transcranial and transmaxillary projections. Abnormalities of structure and shape of the bony components were found in 50% of the joints; cortical/subcortical erosion was recorded in 15%, sclerosis in 33% and deviation in shape in 48%. Abnormal condylar position was observed in 46% of the joints. The 20 patients examined only at the follow-up demonstrated a frequency of these findings similar to those observed in patients selected for examination during the treatment period. At the 7-year follow-up, a slight increase in number of all types of abnormalities was found as well as a slight progression of abnormalities present at the first examination.

Adolescent↗
PubMed1984

Long-term development after treatment of mandibular dysfunction and osteoarthrosis. A clinical-radiographic follow-up and an animal experimental study.

The purpose of this thesis was to investigate the long-term development of signs and symptoms in patients with temporomandibular joint (TMJ) pain/dysfunction after treatment, to analyse factors of importance for the long-term prognosis, to evaluate TMJ radiography in these disorders and to develop a model for experimental joint lesions where also the effects of intra-articular injections of corticosteroid and hyaluronic acid in such joint lesions were studied. Signs and symptoms of dysfunction in the patients treated for TMJ pain/dysfunction were few at the follow-up and significantly reduced compared with the findings at the start of treatment. Less than one fifth of the patients had had recurrent symptoms of some significance. Poor general health was found to have a negative influence on the prognosis. Few correlations were found between occlusal factors and dysfunction. In patients with extremely long periods of treatment psychosocial factors were evident. The long-term prognosis of TMJ osteoarthrosis was as good as for neuromuscular problems but crepitation often persisted at the follow-up. Radiographic abnormalities of structure and shape of the TMJ generally of a small extent were frequent in patients with TMJ pain/dysfunction both in those examined during the treatment period and in those only radiographed at the follow-up. Findings were frequent also in patients treated for mainly mandibular (neuromuscular) dysfunction. At the follow-up a slight increase in number and extent of abnormalities were found. Signs and symptoms of dysfunction showed poor correlation with the radiographic findings. Decreased number of occluding pair of teeth, as well as crepitation, was however positively correlated to abnormalities of structure and shape. The intra-articular injection of papain in guinea-pig knee-joints constantly resulted in development of joint lesions with individual variations. Treatment of such joint lesions with corticosteroid and hyaluronic acid had little influence on the overall lesions, but the results indicate that hyaluronic acid inhibit granulation tissue formation and development of deviation in shape of the joint components.

Adolescent↗
PubMed1983

Long-term results of treatment for temporomandibular joint pain-dysfunction.

The frequency and severity of functional disturbances of the masticatory system were studied in 154 women 7 years after treatment for TMJ pain-dysfunction at the Department of Stomatognathic Physiology, University of Göteborg, Sweden. The results of the 7-year examination were compared with records made prior to treatment. There was a significant reduction of both reported symptoms and clinical signs of dysfunction at 7 years. Although less severe than at the initial examination, clicking of the TMJ and slight muscle tenderness to palpation were the most common clinical findings at 7 years. Eighty-four percent of patients reported that treatment received had resulted in reduction of symptoms. During the 7-year period, 80% of patients had few or no symptoms. Recurrent symptoms of some significance were found in less than 20% of patients, and 14% had returned for further treatment during the 7-year period. It can be concluded that most patients with TMJ pain-dysfunction have minimal recurrent symptoms 7 years after conservative treatment procedures. This indicates that a favorable prognosis may be considered for TMJ pain-dysfunction. This favorable prognosis should be emphasized to patients prior to treatment, as optimistic counseling has been shown to have a favorable effect on patient response to treatment.

Adolescent↗
PubMed1983

Induction of osteoarthrosis in the guinea pig knee by papain.

The main purpose of this investigation was to develop a model for experimental induction of osteoarthrosis. A previously described method using papain was tried on guinea pig knee joints. Eighteen adult guinea pigs were given papain intra-articularly in the right joints; the left joints were used as controls. The animals were killed after 6 hours, 1 week, 2 weeks, 2 months, 4 months, 6 months, 8 months, and 10 months. Specimens of the articular cartilage were removed for histologic and histochemical investigation. Microscopic surface irregularities could be observed in the animals after 6 hours, 1 week, and 2 weeks, and again after 8 and 10 months. Histochemical examination of the sections from the experimental joints indicated a loss and degradation of the sulfated glycosaminoglycans. This loss was evident after 6 hours, 1 week, 2 weeks, and 8 months. The first osteoarthrotic changes were observed macroscopically after 8 months. Radiographic changes in the experimental joints could be observed in all animals killed after 10 months. It was concluded that osteoarthrosis similar to that occurring in humans can be induced by this method.

Animals↗
PubMed1982

Temporal arteritis: a report on two cases.

Temporal arteritis often raises diagnostic problems. The first person to examine the patient may well be a dentist since the first symptoms of the disease are often stiffness of the masticatory muscles and impaired mobility of the lower jaw, reminiscent of mandibular dysfunction/TMJ pain and dysfunction. Other common symptoms are headache, tiredness, slight fever or other general symptoms. Two cases, both elderly women, referred to the Department of Stomatognathic Physiology, Göteborg, are possessed. The clinical features, histopathological findings and therapy are described and differential diagnostic problems are discussed.

Adrenal Cortex Hormones↗