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C Menozzi

Publications and source records attributed to C Menozzi.

124 records · Page 7Linked to original sources
PubMed1977

[Enzymatic assessment of the area of necrosis. I. Diagnosis and quantitative evaluation of acute myocardial infarct by means of MB creatine kinase isoenzyme. Comparison with deduced from creatine kinase activity].

On the purpose of specifying more and more the peculiarity of the isoenzymes MBCK in regard to enzyme CK, in the diagnosis as well as in the quantitative evaluation of myocardial infarction, we examined 34 patients hospitalized in U.C.I.C. The curves of the MBCK and CK were obtained through samples taken every 2-3 hours still the 12th hour, after the enzymatic concentration have exceeded the normal level and successively every 4 hours till the enzymatic activity regains its limits. The values of I.S.MBCK and I.S.CK were compared and we obtained two correlations based on the enteric work (r = 0.79) or on selected cases (r = 0.96). We conclude, for the major practicality and usefulness of measurement of MBCK in the evaluation of size, because this measurement can be obtained on the total enumeration of cases of myocardial infarction, not takine into consideration all those factors which could produce an increase of CK; moreover the MBCK is able to show the extension of myocardial infarction that would not be detectable with CK.

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Carotid sinus syncope: the most frequent neurally mediated syncope in the elderly.

The present work reviews current literature and the authors' experience of carotid sinus syndrome (CSS), which is considered to be the most common cause of neurally mediated acute disorders of consciousness in the elderly. Although no definitive consensus about its nosology has yet been reached, most groups agree that three features fulfill the diagnosis: anamnestic presence of syncope or its minor equivalents, and their reproduction by carotid sinus massage associated with defined values of cardioinhibition or vasodepression or both. The technique for performing carotid sinus massage used by the authors is described; this manoeuvre seems very safe and reproducible as long as simple rules are followed, and it allows the classification of CSS types. The treatment of CSS is varied, according to several factors. No pharmacological therapy has yet been demonstrated to be effective. While severe cardioinhibitory forms require an appropriate pacing, vasodepressive ones and types with only minor symptoms show a more favourable natural history. Pacing is advised in mixed CSS with either frequent and invalidating relapses, or 'high risk' attacks (severe, abrupt, with major traumas, etc.). Finally, the protocol for choosing the adequate mode of pacing is illustrated. In most cases VVI is sufficient, but the decision requires a careful individual examination.

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[A rare case of high dorsal radicular-medullary compression in a patient with ochronotic arthropathy. Clinico-radiological features].

Alkaptonuria is a rare, hereditary, metabolic disease in which homogentisic acid, an intermediary product in the metabolism of phenylalanine and tyrosine, cannot be further metabolized. The metabolic defect causes a characteristic triad of homogentisic aciduria, ochronosis, and arthritis. The cause of this disease is a constitutional lack of the enzyme homogentisic acid oxidase. The condition is inherited as an autosomal recessive disease. The ochronotic arthritis affects mainly male subjects after fourty. Authors present a case of a 60 years old man suffering from a generalized ochronotic arthritis since 1976. From 1992 summer to the beginning of 1993 the patient developed a progressive weakness in the lower limbs associated with thoracic back pain and subsequently a spastic paraparesis. These symptoms were related to a vertebral compression due to D4-D5 pathologic fracture. In spite of a decompressive operation the neurologic symptoms didn't improve.

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