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C Mihalache

Publications and source records attributed to C Mihalache.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Experimental carbon disulfide-induced encephalopathy].

The histopathological and ultrastructural aspects of cerebral cortex were followed up in the white rat injected intraperitoneally with carbon disulphide at 5 mg/kg body weight/week, in a chronic experiment--3, 6, 10 months. Important neuronal damages like: neuronal dystrophy's to neurolysis affecting the pyramidal and granular cells, neuronophagy, nodular and diffuse glial reaction, in the absence of atherosclerotic lesions were noticed. The lesions developed after 3 months and become more extended at 6 months and 10 months: it persists even after 2 months from the moment when the administration ceased.

Animals↗
PubMedDate not supplied

[The dynamics of exposure to silicotic dusts and silicosis in a foundry].

This work presents the concentrations dynamics of dust in a cast iron foundry, in parallel with the frequency and gravity dynamics of the getting sick of silicosis. The knowing of the real risk of exposure to silicotic dust was possible through the data processing concerning the dusting degree (the average of working place), the content of silicon free-crystalline dioxide (SiO2 l.c.) for the calculation of the maximum admitted concentration (C.M.A.) and the dispersion degree of dust in a cast iron and steel foundry for the studied period (1982-1996). New cases of silicosis appeared in this period were studied and they were colligated with the age at declaration, the average length of service and the profession. The values of the dusting degree outrun the C.M.A. up to 168 times, especially at the preparation of mixture and grinding with a prevalence of particles under 3 micron (40-70%) and the Si02 l.c. content varies between 35.2% and 64.5%. From those 98 new cases of silicosis appeared in 15 years, 82.65% were traced out in the incipient phases of the disease. The average age in service and the average age increase (43.1 respective 19.8 years). The coefficients of correlation and regress (+0.286 respective +0.383) show a good correlation between the silicosis number and the age in service. The advanced stages of silicosis and age in service under 10 years were found at the foundry-workers and formators, occupations which imply a high silicotic risk. The foretelling calculations for the next 20 years show an increase of the silicosis incidence for foundry-workers.

Adult↗
PubMedDate not supplied

[The hemorrhagic duodenal ulcer: our experience in its diagnosis and treatment].

AIM OF THE PAPER: To present our experience in the diagnosis and treatment of hemorrhagic duodenal ulcer. MATERIAL AND METHOD: Retrospective study of 80 patients who underwent surgery in our clinic during the past 5 years. Patient's age ranged between 19 and 76 years, the condition being most common during the IVth and Vth decades of life. There were 61 males and 19 female, 49 of them residing in urban areas. In 23 cases the patients presented with an acute hemorrhagic ulcer and in 57 cases with a chronic form. Hemorrhage was by hematemesis (30 cases), melena (36 cases) and hematemesis and melena (14 cases). According to the severity of hemorrhage we found: hemorrhagic shock grade I (mild hemorrhage) in 16 cases, grade II (moderate hemorrhage) in 19 cases, grade III (severe hemorrhage) in 33 cases, grade IV (very severe) in 11 cases and grade V (cataclysmic) in 1 case. Radiological and endoscopic examinations made the diagnosis in 78 and 95% of the cases, respectively. Treatment was surgical in all cases. The patients were operated in emergency, within the first 24 hours (14 cases), or delayed emergency, after 4-7 days (66 cases). Two surgical procedures were performed: truncal vagotomy with ulcer excision/suture and Heineke-Mikulicz pyloroplasty in 46 cases, and truncal vagotomy with antrectomy and Péan anastomosis in 34 cases. RESULTS: Postoperative course was favorable in 76 cases, complications causing death being recorded in 4 cases. CONCLUSIONS: Hemorrhagic gastroduodenal ulcer is a surgical emergency requiring an adequate diagnostic and therapeutic approach. According to our statistics, in most cases the treatment is surgical.

Adult↗
PubMedDate not supplied

[The quality assessment of a product with adhesive properties for complete dental prostheses].

A formula of dental adhesive using as an agent responsible for this activity an indigenous product, C.M.C.Na 1080, gelified with preservative solution with added astringent agents was elaborated. The possible interaction between the constituents during preservation and the product qualities by determining the pH, extensibility index, sliding limit tension, antimicrobial activity and certain clinical aspects were evaluated.

Adhesives↗
PubMedDate not supplied

[Is carbon disulfide atherogenic?].

The changes in serum lipids and the histopathological aspect of aorta and blood vessels in the coronary, cerebral and renal territories were followed up in the white rat injected intraperitoneally with carbon bisulphide at various doses (5, 10, 15, 25, 75 mg/kg body weight) in subacute and chronic experiment (3, 6, 10 months). The absence of hyperlipemia and atherosclerotic lesions in aorta and coronary, renal and cerebral blood vessels were noticed.

Animals↗
PubMedDate not supplied

[Histologic aspects of the testis in experimental carbon disulfide poisoning].

The histological examination of testes was carried out in white male rats poisoned by the intraperitoneal administration once a week for 6 months of carbon disulphide at different doses of 5, 10, 15, 25 mg/kg body weight. The changes consist in interstitial edema, stasis, congestion, seminiferous tubules basement membrane thickening and spermatogenesis suppression at different stages. There is a direct relation between the intensity of the lesions and the administered dose. The ways of spermatogenesis alteration in the presence of interstitial cells of normal aspect are discussed. The authors believe that carbon disulphide had a direct action both on the central nervous system (hypothalamus--FSH releasing factor) and on testicular structures.

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