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Biomedical subjects

C Mittman

Publications and source records attributed to C Mittman.

At least 37 records · Page 2Linked to original sources
PubMed1980

Familial temperature sensitive alpha 1 protease inhibitor (M1Anaheim).

An alpha 1 protease inhibitor which is sensitive to increased temperatures and which migrates in the same position as the normal M1 phenotype, has been identified. The sensitivity of the trypsin inhibitory capacity is an inherited characteristic, which is enhanced by acid conditions, as well as conditions during isoelectric focusing. Loss of the serum trypsin inhibitory capacity is not parallel to that of the serum elastase capacity, suggesting that the inhibitory sites for these proteases are oriented differently within the alpha 1 protease inhibitor molecule.

Adult↗
PubMed1980

Ventilatory muscle training improves exercise capacity in chronic obstructive pulmonary disease patients.

We examined the effect of a 6-wk period of ventilatory muscle endurance training on the maximal sustained ventilatory capacity (MSVC) and on exercise tolerance in 10 patients with chronic obstructive pulmonary disease (COPD). No significant changes occurred in lung volumes or spirometric indices. After training, the MSVC increased from 32 +/- 11 to 42 +/- 13 l/min (P less than 0.001) and the MSVC/FEV1 ratio from 40.2 +/- 8.8 to 47.8 +/- 8.0 (P less than 0.001). Oxygen consumption during the MSVC increased from 460 +/- 94 to 647 +/- 107 ml/min (P less than 0.001), and MSVC heart rate increased from 99 +/- 15 to 114 +/- 15 (P less than 0.001). The post MSVC blood lactate increased from 1.55 +/- 1.29 to 2.85 +/- 1.05 mM/l (P less than 0.001). Maximal exercise ventilation measured by an incremental ergometer test increased from 32 +/- 8 to 36 +/- 11.5 l/min for leg exercise and from 30.4 +/- 8.4 to 33.7 +/- 8.9 l/min (P less than 0.01) for arm exercise. Endurance time at a constant submaximal load increased from 6.98 +/- 4.30 to 10.76 +/- 6.00/min (P less than 0.01) for leg exercise and from 5.76 +/- 3.53 to 10.47 +/- 6.57/min (P less than 0.01) for arm exercise. The maximal distance covered in a 12-min walk increased from 1,058 +/- 161 to 1,188 +/- 201 m (P less than 0.01). We concluded that ventilatory muscle training in patients with COPD improved the ventilatory muscle performance, as indicated by the increased MSVC, oxygen consumption during the MSVC, and the maximal exercise ventilation. There was a substantial increase in submaximal exercise endurance for both arm and leg work.

Diaphragm↗
PubMed1976

Antitrypsin.

Explore the source record for details and available documents.

Genetics, Medical↗
PubMed1975

A simplified method for measuring helium closing volume.

A simple method for delivering a constant volume of helium for the measurement of airway closing volume is described. Using a standard fiveway valve and PVC plastic irrigation pipe, a device was constructed which permits the delivery of a uniform volume of helium and avoids the troublesome valve change during inspiration. Results obtained when using this device were comparable to those with the use of conventional bag to contain the helium.

Helium↗