PubMed Health⌕ Search

Biomedical subjects

C Moerman

Publications and source records attributed to C Moerman.

15 recordsLinked to original sources
PubMed2004

Prolonged schedule of temozolomide (Temodal) plus liposomal doxorubicin (Caelyx) in advanced solid cancers.

Temozolomide (Temodal) is an oral imidazotetrazine. Increased temozolomide exposure and subsequent depletion of O-alkylguanine alkyltransferase may improve the activity of temozolomide. The rationale for investigating temozolomide plus Caelyx is based on their antitumor activity, their formulation and no significant overlapping toxicities. We conducted a study of a prolonged schedule of temozolomide (orally on days 1-7 and 15-21) plus Caelyx (day 1) every 28 days. Twenty-one patients (melanoma n=10, sarcoma n=7 and other n=4) were assigned to four dose levels (DL; temozolomide+Caelyx, mg/m): DL1: 100+30 (n=3 patients), DL2: 100+40 (n=6 patients), DL3: 125+40 (n=6 patients) and DL4: 150+40 (n=6 patients). Dose-limiting toxicities were noted after 2 or more cycles in one patient at DL3 (stomatitis) and one patient at DL4 (grade 4 ANC >/=7 days). Treatment delays and/or dose reductions (due to hematological toxicity) were necessary in five of six patients receiving DL4 compared with one of six patients at DL3, and one patient at DL1 and 2. Thus, the recommended dose was temozolomide 125 mg/m (daily for 7 days every other week) plus Caelyx 40 mg/m (day 1 every 4 weeks). Other toxicities were mild. Antitumor activity was observed in eight patients, including one complete response (melanoma), three partial responses (one melanoma, two sarcomas) and four patients with stable disease (three melanomas, one Ewing), with a duration lasting from 14 to 135+weeks. Two melanoma patients showed tumor stabilization in non-irradiated cerebral lesions. This schedule of temozolomide allowed higher dose intensity (1750 mg/m in 4 weeks) compared to the standard 5-day regimen (1000 mg/m in the same amount of time).

Adult↗
PubMed1993

CT scan and testis tumors.

CT plays an important role in the management of testis tumors both in the initial staging and the follow-up of the patient after treatment. Abdominal CT for the search of lymph node metastases should be part of the initial evaluation but pathology remains necessary to validate the diagnosis.

Humans↗
PubMed1983

Exploring the aphasiac's naming disturbances; a new approach using the neighbourhood limited classification method.

The patterns of errors observed in eighteen patients with aphasia naming 42 different items presented 5 times in random succession were analyzed by the N.L.C. (Neighbourhood Limited Classification) method. The initial and last responses for each item were considered. The procedure allowed the computation of an improvement coefficient for each patient, illustrating the capacity to modify an initially erroneous response. For each type of response a cluster analysis was performed and a grouping of patients was obtained; in both cases some patients had close to normal scores. Clustering was chiefly a function of severity of word-finding disturbance. Phonemic paraphasias follow a more independent course, allowing additional clustering. In the future, more importance should be given to their discriminative value in the taxonomy of naming disturbances.

Aged↗
PubMed1979

Pseudo-tumoural aneurysm in the third ventricle: Report of three cases.

3 cases of giant sacciform aneurysm developed in the third ventricle are reported. They were observed in patients over 50 years. Clinical symptomatology evoked a tumor rather than a vascular malformation. Diagnosis can be difficult even with angiography and CT scan performed conjointly when the giant aneurysm is completely thrombosed. The size of the lesion is not a matter of age since 10% at least of these giant aneurysms are observed in children. They are mainly seen along the large arteries at the neck or at the base of the brain; the high focal pressure of the blood flow at these levels can perhaps play a role in the usual site of these lesions. Surgical treatment remains a challenge when the aneurysm is burrowed deep into the third ventricle and when being thrombosed, it is mainly symptomatic by its mass.

Aged↗
PubMed1977

Aphasics' defective perception of connotative meaning of verbal items which have no denotative meaning.

This study deals with the question of whether in aphasic patients the grasping of connotative meaning is disturbed. The method used was the "maluma - takete" type (Koehler, 1947): matching of synthetic words to meaningless figures. It was proven that asphasics from different countries with different languages have a disturbed perception of connotative meaning. There was a correlation with the severity of language comprehension disturbance in aphasics.

Adult↗
PubMedDate not supplied

Towards a taxonomy of aphasic errors. A pilot study.

Error patterns occurring in an aphasic population performing a naming task were explored by factor analysis. This confirmed the existence of two error types: a phonemic and a semantic one. The latter was about twice as important as the former; as a consequence, a weighting system restoring the balance between both was required before submitting patients' scores to cluster analysis. Suitable weighting coefficients were computed according to data obtained by factor analysis. As defect severity interfered with the results of cluster analysis, scores were weighted in order to neutralize the severity dimension.

Aged↗
PubMedDate not supplied

The background of aphasic misnamings. A factor analysis of visual naming errors.

A factor analysis of 4612 errors recorded among the 12 200 responses made by 61 non-selected aphasiacs, during a visual naming task, was performed; the 14 variables were mostly errors described by the neurologic terminology. The existence of a phonemic and a semantic articulation level was confirmed. A feedback system opening the way to alternative responses ("escape mechanisms") was disclosed. Phonemic paraphasias were the most specific errors at the phonemic level, whereas perseverations turned out to be the purest representative at the semantic one. Verbal semantic paraphasias were apparently not a lesser degree of verbal paraphasias but errors of a different nature (Acta neurol. belg., 1985, 85, 110-122).

Aphasia↗
PubMedDate not supplied

A taxonomy of misnaming aphasiacs.

A cluster analysis, based upon the naming errors of 61 non-selected aphasiacs, was performed. Three clusters emerged; the first was marked by phonemic errors, the second by semantic ones and the third by the use of escape mechanisms. Subjects in the second cluster were less impaired; this could be a consequence of the disturbance type involved. Though many patients of first and third groups displayed a Wernicke aphasia, whereas Broca aphasia predominated in the second one, a concordance of clusters with aphasiologic diagnoses was far from excellent.

Adolescent↗