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C Moesch

Publications and source records attributed to C Moesch.

29 records · Page 2Linked to original sources
PubMed1988

[Glaphenine biliary lithiasis. Identification by infrared spectrophotometry].

The authors report the case of a woman, presenting with choledocholithiasis essentially composed of glafenic acid. Identification of the drug and its metabolites was demonstrated using infrared spectrophotometry and thin layer chromatography. To our knowledge, this is the first publication of drug choledocholithiasis.

Aged↗
PubMed1987

[Identification of a metabolite of floctafenine in urinary calculi].

There are three 4-amino-quinolines used for their analgesic properties: glafenine, antrafenine and floctafenin. Urinary calculi due to glafenine have been described since 1980. Recently two cases of renal calculi containing antrafenic acid have been reported. We discovered a metabolite of floctafenin in a bladder calculus and describe its identification by infrared spectrophotometry and thin-layer chromatography.

Aged↗
PubMed1987

Identification of flumequine in a urinary calculus.

Various analytical methods are available to help identify the presence of drugs in urinary calculi. Using infrared spectrophotometric analysis, nonmetabolized flumequine was identified in a protein calculus from a patient who had taken the drug for a urinary tract infection. Free flumequine can precipitate in an acidic environment.

Aged↗
PubMed1985

[Aminopenicillin crystalluria: identification by infrared spectrophotometry].

Renal stones and crystalluria can be characterized unambiguously by global physical methods. The authors report four cases of crystalluria induced by aminopenicillin (ampicillin and amoxicillin). Identification of these drug-induced crystalluria was made by high-pressure liquid chromatography and infrared spectrophotometry. The physico-chemical data and infrared absorption characteristics can give us diagnostic for various forms of ampicillin and amoxicillin.

Adult↗
PubMedDate not supplied

Relationship between microsatellite instability, response and survival in palliative patients with colorectal cancer undergoing first-line chemotherapy.

BACKGROUND AND AIMS: The aim of this work was to investigate the relationship between microsatellite instability (MSI), treatment response and survival in palliative patients with colorectal cancer (CRC) undergoing first-line treatment with weekly 24-hour infusion (24-h inf.) of high-dose 5-fluorouracil (5-FU) and folinic acid (FA). PATIENTS AND METHODS: Tumour material from the colorectal primary carcinomas was analysed for 43 patients. MSI analysis was carried out and immunohistochemistry was performed with hMLH1 and hMSH2. RESULTS: Tumours of 7 patients (16%) were highly instable (MSI-H). These patients had a better response rate (72% vs. 41%; p = 0.072) and a significantly better median survival (33 months, [95% CI 20-46] vs. 19 months, [95% CI 10-28]; p = 0.021) than microsatellite stable (MSS) patients (n = 36). Furthermore, MSI status was shown to be an independent predictive marker for survival (p = 0.037). CONCLUSION: These data provide further support for the hypothesis that MSI-H CRC might have a better response and survival than (MSS) CRC in palliative first-line treatment.

Adaptor Proteins, Signal Transducing↗