A strain of high-altitude chickens (Gallus gallus) with a high hemoglobin-oxygen affinity has been found in the Peruvian Andes. The purpose in this work was to investigate the relation of this high affinity with the allosteric regulation of the inositol hexaphosphate effector (IHP). The hemoglobin-oxygen affinity has been determined in phosphate-free hemoglobin solutions before and after the addition of IHP. The results showed that the addition of IHP to the phosphate-free hemoglobin solutions increased the affinity significantly less in the high-altitude chicken (26.3 Torr) than in the sea-level chicken (42.2 Torr) (P < 0.001). It was concluded that the high-affinity hemoglobin is probably dependent on a molecular change affecting the allosteric regulation, although a change in the intrinsic properties of the hemoglobin cannot be discarded.

Adaptation, Physiological↗

PubMedDate not supplied

Kidney function in the high-altitude native.

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Acclimatization↗

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[Importance of the blood filamentation test for the rapid diagnosis of Candida albicans].

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Animals↗

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[in vitro comparison of liquid antacids of commercial use].

The aim of our study was to compare the capacity of several liquid antacids to elevate the pH of a hydrochloric acid solution. An experimental model was designed to measure this capacity in different commercially available liquid antacids. Change in pH of an HCl solution was registered when each of the liquid antacids was added. We found differences between the 4 MgOH - ALOH antacids. Minimal difference was found between the 2 commercially available magaldrates.

Antacids↗