Biomedical subjects

C Morales-Angulo

Publications and source records attributed to C Morales-Angulo.

23 records · Page 2Linked to original sources

PubMedDate not supplied

[Otorhinolaryngo logical manifestations in patients with Down syndrome].

OBJECTIVE: The objective [corrected] of our study was to assess the most frequent otorhinolaryngological manifestations in patients with Down syndrome, and to propose diagnostic and management guidelines to improve their quality of life. METHODS: Patients with Down's syndrome referred to the ENT Department of two Spanish Hospitals during a 4-year period were retrospectively reviewed. Data of the following variables were collected: main symptoms, diagnosis, comorbidities, surgical procedures, and complications. RESULTS: Thirty patients with Down's syndrome were included in our study. The most frequent reasons for referral were hearing loss and newborns from the Hearing Impairment Screening Program. Otitis media with effusion, adenoid hypertrophy and obstructive sleep apnea were the most common diagnosis. Five patients underwent head and neck surgical procedures without complications. CONCLUSIONS: Hearing loss secondary to chronic otitis media with effusion and upper airway obstruction are frequent pathologies in patients with Down syndrome.

Adolescent↗

PubMedDate not supplied

[Auditory neuropathy due to the Q829X mutation in the gene encoding otoferlin (OTOF) in an infant screened for newborn hearing impairment].

We report an infant with auditory neuropathy secondary to the Q829X mutation in the gene encoding otoferlin (OTOF). Included in a universal newborn hearing screening program, the subject passed the otoacoustic emission (OAEs) test. Given that the infant had a familial history of deafness auditory brainstem response (ABR) testing was performed, revealing a profound hearing impairment. The genetic study confirmed that the subject was homozygous for the Q829X mutation in OTOF. The patient underwent a cochlear implant, obtaining satisfactory results. The moderately high prevalence of this mutation in the Spanish population could produce a significant false negative rate in newborn hearing screening programs using OAEs.

Cochlear Nerve↗

PubMedDate not supplied

[Biopsy of the temporal artery. Experience with the use of a protocol at an ENT department].

INTRODUCTION: Temporal artery (TA) biopsy is required for the evaluation of several clinical scenarios because of the therapeutic implications of a positive result. We describe the experience of our department, which is the center for this technique in our hospital. PATIENTS AND METHODS: A retrospective study was made of all TA biopsies performed in the Department of Otolaryngology, Hospital Sierrallana, from January 1995 to April 1997. RESULTS: Thirty-four biopsies of the TA artery were performed in 33 patients for possible temporal arteritis. Mean age was 76 years (range: 61-87 years). Twelve were male and 21 female. Twenty-two patients (66.6%) had recent onset cephalalgia, 11 (33.3%) polymyalgia rheumatica, 5 (15.1%) mandibular claudication, and 8 (24.2%) ocular symptoms. In 75.8% ESR was elevated. An abnormal TA exam was observed in 9 cases (27.3%), 6 of which had a positive biopsy. Only 1 of the 15 patients without local findings at the physical examination had a positive TA biopsy. No information on the physical exam was recorded for the other 2 patients with a positive biopsy. CONCLUSIONS: TA biopsy is a relatively easy surgical procedure with a very low rate of complications. An abnormal physical TA examination correlates with a positive histopathological study.

Aged↗

PubMedDate not supplied

[Carcinoma of the nasopharynx in Cantabria].

OBJECTIVE: To describe the incidence and main clinicopathologic features of nasopharyngeal carcinoma (NPC) in Cantabria, Spain, and compare these data with reports published in Spain. MATERIAL AND METHODS: The medical records of all patients with the diagnosis of NPC seen in our division in the last 20 years were reviewed. RESULTS: Eighty-two patients ranging in age from 11 to 84 years were diagnosed as NPC. Sixty-five (79.3%) were males. The initial physical examination of the nasopharynx was normal in 7% of patients. The most frequent presenting complaint was the presence of a neck mass in 47% of cases. Forty percent of patients had cranial nerve involvement and 4.9% had distant metastases at the time of diagnosis. The lateral wall was the most frequent tumor location. The histopathological type was undifferentiated carcinoma in 71% of cases. Most patients had advanced-stage disease at the first visit. CONCLUSIONS: The incidence of NPC in Cantabria is 0.8 per 100.000 inhabitants per year. The highest incidence rate occurred in persons 50 to 70 years-old. Males predominated with a male: female ratio of 4:1. Undifferentiated carcinoma was the most frequent histological type. Our findings were similar to those reported in other series of patients with NPC in Spain.

Aged↗

PubMedDate not supplied

[Foreign bodies in the esophagus].

OBJECTIVE: To study the management (diagnostic and therapeutic) of esophageal foreign bodies. MATERIAL AND METHODS: A retrospective study was made of all rigid esophagoscopies performed for suspected foreign bodies in the esophagus by the otolaryngology department of Marqués de Valdecilla Hospital (Santander, Spain) from 1992 to 1996. RESULTS: Rigid esophagoscopy was performed for suspected foreign bodies in 195 patients (121 females, 74 males; age range 2 to 97 years). In 183 cases an impacted foreign body was found. The most frequent location was the upper third of the esophagus (165/85.2%). The most common type of foreign body was fish bones in adults (75/171) and coins in children (7/12). In 145 cases a barium esophagogram was obtained before surgery, which yielded 1 false negative and 8 false positives. In 16 patients flexible endoscopy had failed previously to remove the foreign body. Twelve patients (all adults) had serious complications. CONCLUSIONS: The barium esophagogram and rigid esophagoscopy are still appropriate techniques for managing esophageal foreign bodies.

Adolescent↗