[Studies on the mode of action of chloroform and halothane in modern anesthesia].
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Anesthesia, Inhalation↗
Biomedical subjects
C Morgenstern
Publications and source records attributed to C Morgenstern.
Oxygen transport to the inner ear.
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Animals↗
Ion transport in the endolymphatic space.
The endolymph differs from all other extracellular fluids in its positive potential and in the ionic compositions in the various parts of the endolymphatic space. The endolymphatic space is surrounded by a tight neuroepithelium. The strial cells, which have a negative intracellular potential of -67 mV, generate a positive endolymphatic potential of +80 mV. The potassium ions are pumped into the endolymph by an active energy-consuming process. Intracellular ion concentrations of the marginal strial cells are 135 mM for potassium and 6 mM for sodium, which are comparable to concentrations in other epithelial cells. During anoxia or after ethacrynic acid injection potassium concentrations in the cochlear endolymph and in the marginal strial cells decrease, while sodium concentrations increase.
Animals↗
Oxygen supply of middle ear mucosa under normal conditions and after eustachian tube occlusion.
The mucosa of the middle ear is not only supplied with oxygen from the blood but also from the air space of the middle ear. Under physiological conditions, the perilymph is supplied partially with oxygen from the tympanic cavity. When the Po2 in the middle ear falls below 57 mm Hg, a net diffusion flux of oxygen from the perilymph to the middle ear induces a loss of oxygen from the inner ear. A negative pressure of 25 mm Hg generated in the middle ear, causes a transudate. Subsequently, slight disturbances of microcirculation should occur in the mucosal membrane. More pronounced negative pressures lead to very distinct disturbances of microcirculation and local oxygen supply.
Animals↗