Biomedical subjects

C N Barnard

Publications and source records attributed to C N Barnard.

At least 91 records · Page 5Linked to original sources

PubMed1975

The autopsy findings in a case of heterotopic cardiac transplantation with left ventricular bypass for ischaemic heart failure.

The autopsy findings in a White man aged 59 years are presented; he underwent heterotopic cardiac transplantation with left ventricular bypass for irreversible left ventricular failure caused by severe ischaemic heart disease. Microscopically, the donor heart showed mild signs of chronic rejection with negligible loss of functional myocardium, and no complications attributable to the surgical technique. Severe, generalised atherosclerosis had resulted in fibrous replacement of the recipient left ventricular myocardium and intra-operative atheromatous embolisation to the brain, the latter being the main contributory factor in the patient's death. Other significant findings were bilateral femoral vein thrombosis with recurrent pulmonary infarction, Aspergillus granulomata of the right lung, cytomegalovirus infection of lungs and oesophagus, Herpes simplex infection of the tongue and oesophagus, and duodenal ulceration with haemorrhage.

Arteriosclerosis↗

PubMed1975

Corrective surgery for transposition of the great arteries.

The results of corrective surgery in 32 patients with transposition of the great arteries (TGA) are reviewed. Patients with TGA and associated defects comprised 47% of the series. The over-all long-term mortality rate was 31%. An acceptable mortality rate of 17,5% was achieved in simple TGA by using a Mustard repair. Good results were obtained with the Rastelli operation for patients with TGA, ventricular septal defect and severe pulmonary stenosis. Results were poor in patients with TGA and unrestricted ventricular septal defects, in whom palliative pulmonary artery banding or corrective surgery under 6 months of age is advocated. The major late complication was patch contraction resulting in pulmonary or systemic venous obstruction.

Aortic Coarctation↗

PubMed1975

Left ventricular bypass.

The removal of the patient's own diseased heart in order to perform a total cardiac transplantation has several disadvantages. A new technique for bypassing the patient's diseased left ventricle by using a cardiac allograft has been developed in our laboratory and applied clinically in 2 patients. This technique carried no direct surgical mortality, and no complications resulting from the patient's own heart being left in situ have been observed thus far. The presence of a second heart lying partly in the anterior mediastinum and partly in the right pleural space appeared to have no deleterious effects. Several advantages over the conventional transplant have been noted and are discussed.

Aorta↗

PubMed1975

The present status of heart transplantation.

Heart transplantation still remains the only form of treatment for patients suffering from terminal heart failure as the result of diffuse myocardial disease. The lack of enthusiasm for this operation has no scientific or moral basis. Our own limited experience and the much wider experience of other workers in this field show that with proper patient and donor selection and careful postoperative management, the results of this operation compare very favourably with those of any transplantation of other organs and in the surgical treatment of other types of terminal diseases.

Adult↗

PubMed1975

Recent results in the surgical treatment of Fallot's tetralogy.

Tetralogy of Fallot consists essentially of two abnormalities: a large, unrestrictive ventricular septal defect and severe obstruction to the outflow of the right ventricle. A clear understanding of the principles described in this article should result in a mortality of under 5% after complete correction of tetralogy of Fallot.

Aorta↗

PubMed1974