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Biomedical subjects

C N Chua

Publications and source records attributed to C N Chua.

14 recordsLinked to original sources
PubMed2004

Treatment of aberrant facial nerve regeneration with botulinum toxin A.

PURPOSE: To assess the effect and efficacy of botulinum toxin type A (BTX-A) at reducing and maintaining eyelid synkinesia in aberrant facial nerve regeneration, while concurrently observing for the presence of side effects to differing treatment doses. METHODS: A prospective interventional study of five patients with eyelid synkinesia resulting from aberrant regeneration of the facial nerve. Patients were treated with injections of either 120, 80 or 40 units of BTX-A (Dysport) into the orbicularis oculi. Objective and subjective reduction in synkinesia, maintenance of response and presence of side effects were recorded. RESULTS: All five patients had improvement of the synkinesia with BTX-A treatment. Lower doses were found to be as effective as higher doses. Mean duration of abolished synkinesia was three months. Two patients developed a ptosis which resolved spontaneously. None of the patients treated with the lowest dose of 40 units developed a ptosis. CONCLUSION: Low-dose BTX-A has a lower incidence of ptosis and is effective in the treatment of aberrant facial nerve regeneration.

Adult↗
PubMed2002

Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes.

BACKGROUND & AIMS: There are few systematic studies on the natural history or immunogenetic associations of erythema nodosum (EN) or ocular inflammation in inflammatory bowel disease (IBD), but they are reportedly more common in patients with other extraintestinal manifestations (EIMs), particularly arthritis. Immunogenetic associations have previously been described in IBD arthritis and in EN associated with sarcoidosis. This study examined the clinical features and HLA-B, DR, and tumor necrosis factor alpha (TNF-alpha) associations of ocular inflammation and EN and their clinical and immunogenetic relationship to arthritis in IBD. METHODS: Details of EN and ocular inflammation were gathered by case-note review and questionnaire in 976 ulcerative colitis patients and 483 Crohn's patients. Sequence-specific PCR typing for polymorphisms in HLA-B, DR, and TNF-alpha was performed in 39 EN and 40 ocular patients. Results were compared with 490 IBD controls without EIMs, 38 patients with type 1 and 31 with type 2 peripheral arthritis, and 16 AS patients. RESULTS: EN and ocular inflammation were more common in women, were associated with IBD relapse, and recurred in approximately 30% of patients. They occurred more commonly with arthritis and AS than expected by chance. Ocular inflammation was strongly associated with HLA-B*27, B*58, and HLA-DRB1*0103. There is a weak association between EN and HLA-B*15 but a strong association with the -1031 TNF-alpha. CONCLUSIONS: EN, uveitis, and arthritis associated with IBD occur together commonly. They are associated with genes in the HLA region, and linkage disequilibrium between these genes may account for the clinical picture of overlapping but independent clinical manifestations.

Erythema Nodosum↗
PubMed2001

Refractive changes following Nd:YAG capsulotomy.

PURPOSE: To investigate the effect of Nd:YAG capsulotomy on refractive changes and the need for a post-capsulotomy refraction. METHODS: Forty-two eyes with uncomplicated phacoemulsification and implant (AMO@Phacoflex II) were included. Autorefraction and subjective refraction were performed to get the best visual acuity before and after Nd:YAG capsulotomy. RESULTS: The spherical equivalent before the Nd:YAG capsulotomy was -0.61 +/- 0.90 and after the capsulotomy, -0.57 +/- 0.84. Using the paired Student's t-test there was no significant difference in the refraction following Nd:YAG capsulotomy. CONCLUSION: Routine refraction following Nd:YAG capsulotomy in patients who have had uncomplicated phacoemulsification using AMO@Phacoflex II intraocular lenses is not necessary.

Aged↗