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Biomedical subjects

C N Huang

Publications and source records attributed to C N Huang.

28 records · Page 2Linked to original sources
PubMed1995

[Epidermoid cyst of testis: benign testicular tumor].

Epidermoid cyst of the testis is very rare and accounts for approximately 1% of all testicular tumors. In the clinical examination, the testis has a palpable mass. Pathological findings usually reveal a squamous cell lined cyst, containing keratin, and the absence of appendages and teratoma element. If scrotum ultrasonography reveals a target sign suggestive of epidermoid cyst, the testis should be explored through an inguinal incision. Clamp the spermatic cord gently, and perform tumor enucleation. The frozen section is available at the time to check for any malignant cells. If no malignant cells exist, it is important to perform testis-preserving surgery, especially for young adults and children. We report two cases of epidermoid cyst. Serum beta-HCG and alpha-fetoprotein were within normal limits. We review our experience with scrotum ultrasonography and testis-preserving surgery in 2 men with epidermoid cyst to indicate when the clinical and intraoperative characteristics justify testis-preserving management.

Adolescent↗
PubMed1995

Recent experience of penile fracture (1989-1993).

Penile fracture is an uncommon injury in the genitourinary organ which occurs following a blunt injury on the rigid penis. Penile fracture with urethral injury is even rarer. A total of 11 new patients with penile fracture were treated at our institution from 1989 to 1993. All of these injuries occurred during sexual intercourse and received immediate surgical repair to preserve the sexual function. Only one patient with complete transection of the urethra received end-to-end anastomosis of the urethra. Unfortunately, he suffered from urethral-cutaneous fistula ten days later. Suprapubic urinary diversion was performed in 3 patients with partial urethral tearing, and they enjoyed satisfactory outcomes during the limited follow-up. Immediate surgical repair of tunica albuginea is recommended for preserving penile function. If associated with partial urethral tear, suprapubic urinary diversion is sufficient to treat urethral lesions.

Adult↗
PubMed1994

The altered expression of cytokeratin polypeptides in carcinomas of human bladder.

After extraction in high salt buffers and Triton X-100, cytokeratin polypeptides could be isolated from normal epithelium and transitional cell carcinoma of the human bladder in the southwestern coast of Taiwan. The polypeptides were solubilized via lysis buffer, separated by two-dimensional gel electrophoresis, and identified by immunoblot. Five cases of normal epithelium expressed cytokeratin No. 5 (58 kd), 7 (54 kd), 18 (45 kd) and one case further expressed cytokeratin No. 19 (40 kd) in addition to the above cytokeratins. Combined patterns of cytokeratin polypeptides were observed among various Grades of transitional cell carcinoma of bladder. Comparing the patterns between the normal epithelium and the transitional cell carcinoma of bladder, 88% (14/16) of carcinomas expressed cytokeratin No. 8 (52.5 kd) and 63% (10/16) expressed No. 17 (46 kd), which were not seen in the normal epithelium. Some other cytokeratin polypeptides particular to carcinomas were No. 4 (59 kd), No. 10 (56.5 kd), No. 13 (54 kd) and No. 14 (50 kd) and were only present in less than 50% (ranging from 31-56%) of the examined specimens. Thus cytokeratin No. 8 and 17 could be helpful markers for diagnosis of bladder carcinoma.

Carcinoma, Transitional Cell↗
PubMed1993

Acute myocardial infarction caused by transnasal inhalation of amphetamine.

A 42-year-old man developed acute myocardial infarction 20 minutes following transnasal inhalation of amphetamine. To our knowledge, no cases of amphetamine-induced myocardial infarction by transnasal inhalation have ever been reported. Consequently its pharmacological effects on the cardiovascular system are discussed.

Administration, Inhalation↗
PubMed1993

Urolithiasis related to laxative abuse.

Urinary calcareous disease related to laxative abuse is rare. The gastrointestinal loss of fluid and electrolytes leads to chronic depletion of the urinary volume, relative supersaturation and many other pathophysiologic derangements. These calculi are generally radiolucent with uric acid and ammonium acid urate as major components. We report on a female patient with frequent, repetitive formation of urinary calculi and rapid double J stent encrustation, which were related to the chronic abuse of bisacodyl. Although these stones can be fragmented successfully by extracorporeal shockwave lithotripsy, it seems that the better treatment for this type of stone formation is to avoid the abuse of laxatives.

Adult↗
PubMed1993

Experience in the morbidity associated with double-J catheter indwelling and its management.

Placement of internal ureteral stents for internal urinary diversion and prevention of urological complications has been well established. However, indwelling stents have occasionally been associated with patient morbidity and intolerance. A total of 255 patients while the internal ureteral stent had been used were analyzed. The symptoms including urinary frequency (42.0%), hematuria (41.6%) and suprapubic pain (20.4%), loin pain (17.3%) and micturition pain (16.9%) accounted for the major complaints of the stent indwelling patients. The major complications, i.e. stent migration, heavy encrustation, pyelonephritis, fragmentation, intolerance and penetration of collecting structure, were occasionally observed. These complications increase secondary morbidity in patients. The double-J stents should be used carefully with regard to the prevention and treatment of untoward conditions as early as possible.

Adolescent↗
PubMed1989

Life table method for analyzing relationship between smoking and hypertension.

The life table method is introduced for describing the relationship of smoking amount to prevalence rate of hypertension. The smoking level at different sex groups are collected and grouped according to their cumulative smoking amount. Using the total number of peasants, and the number of hypertensives in each group, one is able to calculate the probability of occurrence of hypertension for each dose group as well as for each cumulative dose group, which indicated that there was a dose-effect curve in estimating the relationship between the cumulative smoking and the probability of hypertension, and females presented a significantly higher probability of hypertension than males in same smoking level.

Adult↗
PubMed1986

Ca-stimulated secretion of alpha-amylase during development in barley aleurone protoplasts.

The effects of gibberellic acid (GA(3)) and Ca(2+) on the synthesis and secretion of alpha-amylase from protoplasts of barley (Hordeum vulgare L. cv Himalaya) aleurone were studied. Protoplasts undergo dramatic morphological changes whether or not the incubation medium contains GA(3), CaCl(2), or both. Incubation of protoplasts in medium containing both GA(3) and Ca(2+), however, causes an increase in the alpha-amylase activity of both incubation medium and tissue extract relative to controls incubated in GA(3) or Ca(2+) alone. Isoelectric focusing shows that adding Ca(2+) to incubation media containing GA(3) increases the levels of alpha-amylase isozymes having high isoelectric points (pI). In the presence of GA(3) alone, only isozymes with low pIs accumulate. The increase in alpha-amylase activity in the incubation medium begins after 36 hours of incubation, and secretion is complete after about 72 hours. Protoplasts require continuous exposure to Ca(2+) to maintain elevated levels of alpha-amylase release. Immunoelectrophoresis shows that Ca(2+) stimulates the release of low-pI alpha-amylase isozymes by 3-fold and high-pI isozymes by 30-fold over controls incubated in GA(3) alone. Immunochemical data also show that the half-maximum concentration for this response is between 5 and 10 millimolar CaCl(2). The response is not specific for Ca(2+) since Sr(2+) can substitute, although less effectively than Ca(2+). Pulse-labeling experiments show that alpha-amylase isozymes produced by aleurone protoplasts in response to GA(3) and Ca(2+) are newly synthesized. The effects of Ca(2+) on the process of enzyme synthesis and secretion is not mediated via an effect of this ion on alpha-amylase stability or on protoplast viability. We conclude that Ca(2+) directly affects the process of enzyme synthesis and transport. Experiments with protoplasts also argue against the direct involvement of the cell wall in Ca(2+)-stimulated enzyme release.

Journal Article↗