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Biomedical subjects

C N Still

Publications and source records attributed to C N Still.

At least 19 recordsLinked to original sources
PubMed1991

A report on dementia in South Carolina, 1988-1990.

With the over age 65 population growing at a faster rate than the under 65 population, and with the strong effect of age on the incidence and prevalence of dementia, South Carolina faces a major health problem among its elderly residents by the year 2010. This report summarizes data on the 4,283 persons identified by the Statewide Alzheimer's Disease and Related Disorders Registry during the period 1988 to 1990. Sixty-one percent of these cases had a diagnosis of Alzheimer's disease or senile dementia and 62 percent of these were currently institutionalized. The demographic distribution of the AD cases did not change over the three-year period. Compared to community cases, those in institutions were generally older, and more likely to be women, unmarried, and white. The average time from onset of symptoms to diagnosis of AD was about five years.

Aged↗
PubMed1990

Distribution of major dementias by race and sex in South Carolina.

Preliminary data from the newly implemented Registry for dementing illnesses was used to examine the distribution of four types of dementia in black and white residents of South Carolina. The data for 1464 subjects were abstracted by field research nurses in state mental health facilities. Overall, 649 patients (44.3%) were black and 765 (52.3%) were white. Women comprised 53.8% of all cases of dementia in this study. The overall distribution included 66% Alzheimer's disease (AD), 12% multi-infarct dementia (MID), 10% alcoholic dementia (ALC), nine percent other-medical and three percent other-unspecified. Though the proportion of blacks does not exceed one-third of the total population of S.C., blacks comprised 44.3% of all cases of dementia. AD accounted for 79% of all cases of dementia in women, but only 51% of such cases in demented men, who showed an apparent preoponderance of MID and alcoholic dementia. The frequency distribution of MID was equal in blacks and whites. Educational level had no discernible effects. Though not directly comparable, these preliminary findings are similar to those of the Copiah County Study, including a higher frequency of AD with advancing age.

Aged↗
PubMed1990

The need for an Alzheimer's disease patient registry in South Carolina.

There has been considerable interest in establishing a statewide registry of Alzheimer's disease patients. The need for such a registry, how it could be effectively organized, and the potential benefits from such a registry are discussed. The current status of the South Carolina Registry for Dementing Illnesses is reported.

Aged↗
PubMed1984

Involuntary movement disorders.

Excluding surgical procedures, this article focuses on clinical pharmacotherapeutic approaches to treatment of parkinsonism and tremor, chorea, dystonia, tic, and tardive dyskinesia.

Brain↗
PubMed1983

Recognition of cognitive impairment in primary care outpatients.

We evaluated 100 primary care outpatients for signs of cognitive impairment using the Mini-Mental State Examination (MMSE). The 23 subjects scoring abnormal values (less than 24/30) were found to be cognitively impaired. Seventeen had previously undetected cognitive impairment, while six had prior diagnoses consistent with cognitive impairment. Independent psychiatric evaluation identified these 23 outpatients as cognitively impaired, confirming the MMSE as a reliable, rapid instrument for cognitive assessment.

Adult↗
PubMed1983

Mini-object test: a new brief clinical assessment for aphasia-apraxia-agnosia.

Primary degenerative dementia (Alzheimer's disease) is characterized by intellectual decline with impairment of memory, judgment, and abstract thinking. Also common are personality changes and disturbances of higher cortical function such as aphasia, apraxia, and agnosia. Standardized brief cognitive tests are useful for evaluating mental status, which is often limited by short attention span, distractibility, fatigability, mental retardation, illiteracy, and/or confusion. Data from 225 institutionalized patients support the mini-object test (MOT) as a valid, reliable, cost-effective, portable screening procedure for confirming the clinical diagnosis of aphasia-apraxia-agnosia associated with senile dementia of the Alzheimer type. Further studies are needed to demonstrate the diagnostic value of the MOT in other dementing disorders.

Aged↗
PubMed1981

Huntington's disease in black kindreds in South Carolina.

Since the first report in 1890 of hereditary chorea in a black family, there have been few epidemiologic references to Huntington's disease (HD) in blacks and, to our knowledge, no estimates of the prevalence of HD in blacks in the Unites States. On Jan 1, 1980, the estimated minimum prevalence of HD in blacks in South Carolina was 0.97 per 100,000 persons, about one fifth the prevalence for white patients with HD in South Carolina. However, detailed studies of eight newly reported cases of HD from four black kindreds indicate that the mean age of onset (41.75 +/- 4.33 years) and clinical course resemble those of white patients with HD in South Carolina. We comment on possible roots of this prevalence difference between whites and blacks with HD.

Adult↗
PubMed1978

Hysterical symptoms masking brain stem glioma.

To function effectively as primary care specialists, psychiatrists must remain ever alert to the possibility of organic disorders in patients who at first show only psychiatric symptoms. A case is presented in which hysterical overlay led to misdiagnosis in a 31 year woman, who dies of a diffuse medullary glioma 3 1/2 years after onset of "conversion" symptoms. The authors point out how the label "hysterical" clouds longitudinal objective diagnostic observations especially when initial clinical and laboratory data fail to support a definitive organic diagnosis.

Adult↗
PubMed1977

Postmenopausal Parkinsonism: brain iron overload?

Records of 11 postmenopausal parkinsonism patients were evaluated in comparison with those of 11 postmenopausal depression patients. None had a history of encephalitis, stroke, drug-induced or toxic extrapyramidal disorders, or active bleeding within six months before admission. There was no significant differences between the two groups with regard to time interval from menopause to onset of symptoms, height, weight, or age at first admission. Both groups showed normal height, hemoglobin, hematocrit, and erythrocyte counts. Parkinsonism patients were underweight and had a shorter interval from menopause to onset of symptoms (12.4 +/- 1.9 vs. 16.8 +/- 2.5 yr.). These findings are compatible with the hypothesis that in parkinsonism, hereditary predisposition to positive body iron balance may be associated with alteration of the blood-brain barrier in parkinsonism.

Age Factors↗
PubMed1976

Long-term levodopa therapy for torsion dystonia.

Observation of a 34-year-old woman receiving levodopa for familial torsion dystonia over a four-year period revealed that severe side effects (gastrointestinal problems, dyskinesias, cramps, anxiety) occurred with maximal dosage schedules during the first ten months of treatment. Thereafter, a gradual reduction of the daily dose to 1,500 mg of levodopa gave excellent relief of hypokinesia and rigidity with minimal adverse effects, including abolition of mild akinesia paradoxica which developed after 2 1/2 years of treatment.

Adult↗