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Biomedical subjects

C N Sun

Publications and source records attributed to C N Sun.

At least 37 records · Page 2Linked to original sources

Cytoplasmic annulate lamellae and intranuclear membranes in human spermatids and sperm.

In human spermatide cytoplasmic annulate lamellae and intranuclear lamellae were found. In the cytoplasm, the annulate lamellae may vary from 3 to 11 layers of cisternal structures. There is evidence that the annulate lamellae are formed from the outer nuclear envelope. The intranuclear membranes are often seen directly connected to the inner nuclear membrane. These morphologic findings suggest that annulate lamellae may be involved in the transfer of genetic material from the nucleus to the cytoplasm.

Adult↗

Abnormal mitochondria in retinoblastoma.

In examination of six retinoblastoma tumor specimens, bizzare mitochondria were often found. Some are irregular forms with focal expansion and constrictions. Occasionally, a portion of the mitochondria forms rings. Branching mitochondria are also seen. Other striking features of the mitochondria from tumor cells are the alternation of cristae. Dense bodies are also occasionally observed within the mitochondria. Morphological modifications of the mitochondria may be as results of pathological conditions of the tumor cells.

Humans↗

Extracellular cross-striated banded structures in human connective tissue.

Extracellular cross-striated banded structures have been found in the connective tissues of a variety of organs. Rarely have they been found in conditions such as: hyperplastic parathyroid, follicular adenoma of the thyroid, metastatic hemangiopericytoma in the lung, sarcoidosis of lymph node, and two biopsies of nerve as reported here. The shape and size of the structure varies, as well as its periodicity, which is usually in the range of 1000 to 15000 A. An unusual exception to this general rule is the banded structure in the follicular adenoma of the thyroid where the periodicity is 270 A. These structures are quite different from native collagen or experimentally reconstituted long-space collagen, both by staining reaction with phosphotungstic acid or uranyl acetate and lead nitrate, and in their ultrastructural morphology.

Adenoma↗

Tuberous sclerosis complex and renal angiomyolipoma. Collective review.

Numerous case reports of renal angiomyolipoma with or without tuberous sclerosis continue to be published with increasing frequency in the urologic literature. The need for a comprehensive and updated review of the subject is timely. A collective pathologic, clinical, and radiologic review of the subjects of tuberous sclerosis complex and renal angiomyolipoma is presented; and a plan for the urologic management is discussed.

Blood Vessels↗

Renal angiomyolipoma in a case of tuberous sclerosis, an electron microscopy study.

Electron microscopic study of bilateral renal angiomyolipoma in a case of tuberous sclerosis showed two cell types: smooth muscle cells and fibroblasts. There were no tubular or glomerular elements within the tumor mass. To our knowledge this study represents the first ultrastructural demonstration of smooth muscle cells occurring in the renal lesions of this complex.

Adult↗

Oncocytoma (mitochondrioma) of the parotid gland. An electron microscopical study.

Electron microscopical study of an oncocytoma of the parotid gland disclosed the presence of two cell types, typical oncocytes and condensed oncocytes. The typical oncocyte contains abundant mitochondria that were tightly packed almost completely filling the entire cytoplasm. Only small areas were left for the remaining cytoplasmic organelles. The nuclei in these typical onocytes appeared oval or spheroid. Condensed oncocytes were scattered singly or in nests in tumorous tissue. These cells were also replete with mitochondria, but differed, however, in that many mitochondria showed evidence of degeneration and fusion. Nuclei of these cells were irregular, dense, and contained inclusions and glycogen granules. The relationship of nuclear envelopes to mitochondria and other cellular components has been described previously, but to our knowledge, this represents an original finding in the case of an oncocytoma.

Adenoma↗