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Biomedical subjects

C Naidoo

Publications and source records attributed to C Naidoo.

28 records · Page 2Linked to original sources
PubMed1985

Idiopathic premature ovarian failure. A clinical and biochemical study.

Thirty-five black patients with premature ovarian failure were studied. All had normal female karyotypes. Vasomotor symptoms were present in 62% of patients and 60% experienced dyspareunia. Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were raised and circulating oestradiol levels were low in all patients. Ten patients consented to provocative challenge with gonadotrophin-releasing hormone and thyrotrophin-releasing hormone (TRH). After testing, FSH and LH levels were exaggerated in all 10 patients. During TRH administration, thyroid-stimulating hormone levels were within normal limits in 5 patients, elevated in 4 and low in 1. Prolactin responses were raised in 1 patient, subnormal in 1 and within the reference range in 8.

Adult↗
PubMed1984

The growth hormone responses to L-dopa and TRH in acromegaly.

The GH responses to TRH and L-dopa were investigated in 14 Indian and African patients with untreated acromegaly. A positive response to L-dopa (greater than 50% change from basal) was obtained in 6 of the 14 patients tested while a positive response to TRH (greater than 100% change from basal) was found in 5 of 12 patients tested. While 9 patients responded to at least one agent, only 2 had a positive response to both agents. Positive responders appeared to be hyper-prolactinemic and have evidence of abnormal glucose tolerance as compared to nonresponders.

Acromegaly↗
PubMed1984

Pituitary function in Sheehan's syndrome.

The responses of plasma prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and thyroid-stimulating hormone were measured in ten women with Sheehan's syndrome after intravenous administration of the appropriate releasing hormones. Growth hormone and cortisol responses to insulin-induced hypoglycemia were also measured. It was found that two patients were biochemically borderline euthyroid and eight were probably hypothyroid in the face of thyroid-stimulating hormone values in the reference range; in two patients thyroid-stimulating hormone response to thyrotropin-releasing hormone was appropriate. In no patient were the minimum prolactin levels achieved, in response to thyroid-releasing hormone as established in reference subjects. Growth hormone response to hypoglycemia was inadequate in all patients and only one patient achieved reference range values of cortisol during hypoglycemia. In six patients fasting LH and FSH were in the reference range and the response to gonadotropin-releasing hormone was adequate and appropriate in eight patients. In light of these findings it is suggested that prolactin response to thyrotropin-releasing hormone administration would be a reliable and simple screening procedure for suspected Sheehan's syndrome.

Adult↗
PubMed1983

The sex hormone profile of male patients with breast cancer.

The mean total serum oestradiol level was found to be significantly increased in 8 patients with carcinoma of the breast when compared with 8 healthy reference subjects matched for race, sex and age. The calculated mean free oestradiol index was also higher in these patients. There were no significant differences, however, between the levels of LH, FSH, prolactin. DHEA-S, testosterone and SHGB in the 2 groups. The patients showed a significantly increased LH response to GnRH while there was no difference in the FSH response. Only 1/7 patients had a tumour devoid of steroid hormone receptors. It may be that an increased level of circulating oestradiol-17 beta is an important factor in the aetiology of hormone-dependent male breast cancer.

Adult↗
PubMedDate not supplied

Acute insulin response to glucagon, tolbutamide, and glucose in non-insulin-dependent diabetes of the young.

Acute insulin release in response to maximal intravenous doses of glucose (0.5 g/kg), tolbutamide (1 g), and glucagon (1 mg) was studied in 10 subjects with non-insulin-dependent diabetes of the young (NIDDY) and 10 age-, sex-, and weight-matched controls. Diabetic subjects had attenuated insulinemic responses to all three stimuli, in comparison with control subjects. However, insulin responses to glucagon and tolbutamide were higher than those obtained with intravenous glucose. This study demonstrates that the pancreatic beta-cell is more responsive to nonglucose secretagogues than to glucose stimuli in individuals with NIDDY.

Diabetes Mellitus, Type 2↗