Biomedical subjects

C Naizot

Publications and source records attributed to C Naizot.

5 recordsLinked to original sources

PubMed1987

Renal amyloidosis in children: an ultrastructural study.

Eleven renal biopsy specimens from 10 children affected with systemic amyloidosis were studied by electron microscopy. Focal parietal deposits of amyloid fibrils and detachment of podocytes were observed in the 9 patients having marked proteinuria. Adjacent capillary loops were normal with intact podocyte foot processes. In the 2 renal biopsies obtained after treatment of the underlying disease a double layer of subendothelial and subepithelial basement membrane material enclosed the parietal amyloid deposits and separated them from adjacent cells.

Adolescent↗

PubMed1982

[Glomerular lesions in renal transplants].

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Graft Rejection↗

PubMed1981

Alport's syndrome. A report of 58 cases and a review of the literature.

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Adolescent↗

PubMed1980

Glomerular basement membrane changes in nonhereditary glomerular diseases.

Some examples of glomerular lesions developing in different types of nonhereditary glomerular diseases have been described. In most of them, secondary glomerular basement membrane changes are important factors in the development and progression of the glomerular lesions. When severe, they initiate irreversible glomerular scar formation.

Antigen-Antibody Complex↗

PubMed1980

Glomerular basement membrane changes in hereditary glomerular diseases.

Ultrastructural glomerular basement membrane changes are present in most hereditary glomerular diseases: thick and thin basement membrane with splitting of the lamina densa in Alport's syndrome, thin basement membrane in familial benign essential hematuria, and thick basement membrane with the presence of collagen-like fibrils in the nail-patella syndrome. They are useful markers for diagnosis. Moreover, their knowledge has set the problem of the primary biochemical defect in basement membrane metabolism accounting for morphological abnormalities and clinical disturbances. Further biochemical and immunochemical investigations are still required for a better understanding of hereditary glomerular diseases.

Adolescent↗