Biomedical subjects
C Nash
Publications and source records attributed to C Nash.
Ras oncoprotein inhibitors: the discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex.
The nucleotide exchange process is one of the key activation steps regulating the ras protein. This report describes the development of potent, non-nucleotide, small organic inhibitors of the ras nucleotide exchange process. These inhibitors bind to the ras protein in a previously unidentified binding pocket, without displacing bound nucleotide. This report also describes the development and use of mass spectrometry, NMR spectroscopy and molecular modeling techniques to elucidate the structure of a drug-protein complex, and aid in designing new ras inhibitor targets.
Effect of trimethoprim on lamivudine bioavailability.
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Atovaquone as prophylaxis for Pneumocystis carinii.
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Capacity to complete an advance directive.
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HLA DR4 is associated with the development of multiple basal cell carcinomas and malignant melanoma.
An association between HLA DR4 and the development of multiple basal cell carcinomas (BCC) and malignant melanoma (MM) was detected in southern Australia. There were highly significant differences in HLA DR frequencies between patients with multiple BCCs and MM and matched patients with multiple BCCs only. These findings suggest that hereditary factors associated with the HLA system influence what types of multiple skin cancers people develop.
Interpreting cultural difference in medical intervention: the use of Wittgenstein's "forms of life".
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Basal-cell carcinoma in temperate and tropical Australia.
The clinical features of patients with basal-cell carcinoma (BCC) living in temperate and tropical Australia were studied. In the temperate zone the patients were considerably older on average, men outnumbered women and there were differences between the sexes in the site of the prevalent BCC. In the tropics the patients were significantly younger on average, the male-to-female ratio approached unity and there were no differences between the sexes with regard to the site of the BCC.
HLA-DR1 is not a sign of poor prognosis for the development of multiple basal cell carcinomas.
BACKGROUND: HLA-DR1 is associated with the development of multiple basal cell carcinomas (BCC). However, the association is weak. OBJECTIVE: The purpose of our study was to determine whether HLA-DR1 is a marker for susceptibility to the development of many BCCs during a lifetime. METHODS: Persons with multiple BCCs were placed into two groups: those with less than 10 and those with 20 or more. In addition, the HLA-DR1 frequencies were analyzed. RESULTS: HLA-DR1 was associated with multiple BCCs in the group with less than 10 BCCs but not with the other group. These patients were significantly younger on average than those with 20 or more BCCs. CONCLUSION: HLA-DR1 is associated with the development of multiple BCCs at an early age but it is not associated with development of large numbers of BCCs. The amount of UV light a person receives appears to be more important.
Basal cell carcinoma in tropical Australia.
A survey of people with skin cancer in tropical Australia detected a change in site of the prevalent cancer. In the post-war generation more basal cell carcinomas are occurring on the back and fewer on the head and neck. A reversal of the sex ratio was also detected, with more women being afflicted.
Prevention of post-excisional wound infections: a comparison of oral cephalexin with topical mupirocin and topical cetrimide-chlorhexidine cream.
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The changing face of skin cancer in Australia.
A survey of patients with basal cell carcinomas (BCCs) revealed that major changes have occurred since the World War II. In the pre-World War II generations, men out-number women and most BCCs occur on the head and neck. Men had more BCCs on the ear and trunk, while women had more on the head and leg. In the post-World War II generation, women outnumbered men and most BCCs occurred on the trunk.
Newborn screening in the 80's--the automation of follow-up.
The Genetic Diseases Program of the Illinois Department of Public Health has completed the requirements for automation of its newborn screening follow-up services. The integration of two databases containing laboratory and follow-up elements allows the system to: (1) process on-line information about both normal and abnormal results on every baby screened in Illinois, (2) recall data previously entered and add follow-up criteria, (3) generate form letters, (4) track treatment and developmental progress of confirmed clients, (5) maintain permanent demographic registries, (6) transfer records to microfiche, and (7) generate reports for statistical analysis. The intent of this paper is to describe each of the above capabilities and demonstrate how automation has enhanced the follow-up component of newborn screening.
Interferon administered in the cerebrospinal space and its effect on rabies in rabbits.
Because combined administration of intramuscular and intravenous interferon has been partially successful in the incubationary treatment of rabies, the effect of direct interferon administration into the cerebrospinal fluid space was tested. After injecting 1,800 U of interferon into the cisterna magna or the lateral ventricle, periodic samples, obtained by cisternal taps, showed that 1 to 5% remained after 24 h, as opposed to the known clearance of interferon from the bloodstream to this level within minutes. The distributions of interferon and (131)I-labeled albumin were similar as demonstrated by kinetics of clearance monitored over 24 h. Beginning with and after experimental infection of rabbits, daily intraventricular injections of one million units of interferon were given for as long as 3 weeks. Interferon was prepared from cell culture fluids after pressure dialysis and chromatography on Sephadex G-100. This intensive treatment did not prevent encephalitis, but prolonged the length of the incubation period by one- to two-thirds. The outcome after intraventricular administration was not as favorable as when one million units equally divided between intramuscular and intravenous injections were given at the time of challenge. Interferon administered in the subarachnoid space in this fashion is apparently inadequate to protect the rabbit against rabies. Its role as an adjunct measure, or other methods of administration in the nervous system, remains to be examined.
Modification of Listeria monocytogenes infection during unrelated cell-mediated immune reactions.
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Radiation response of L cells treated with dimethyl sulfoxide.
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