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Biomedical subjects

C Nogues

Publications and source records attributed to C Nogues.

15 recordsLinked to original sources
PubMed1990

Five months of daily standardized exercise for sedentary monkeys.

A system to physically exercise rhesus monkeys is described, based on their natural capacity to climb. It is composed of an enclosure where a motor-driven rope is continually going down. The two stage training to this task is easily performed. The total work of each run, evaluated with the weight of the animal and the distance climbed, may be very stable. It was used to provide five sedentary monkeys with daily physical training for five months.

Animals↗
PubMed1988

A new technique for iliac crest biopsy in rhesus monkeys for use in weightlessness experiments: some results of ground studies.

The similarity of major physiological functions between man and monkey make non-human primates a suitable model, especially for experiments in weightlessness. Bone tissue of rhesus monkeys can easily be analysed by histological techniques in order to appreciate the effects of hypogravity upon the skeletal system. A technique for iliac crest biopsy has been developed in a laboratory. It is to be used on rhesus monkeys used in various experimental situations, and especially after exposure to the space environment.

Animals↗
PubMed1987

Histiocytes X and X body reactivity with concanavalin A, peanut agglutinin and BSPT.

The ultrastructural and histochemical exploration of histiocytes X done by the means of Concanavalin A (Con A), peanut agglutinin (PNA) and BSPT demonstrate that the plasma membrane of histiocytes X shared some properties with all the other cells and is also specialized. The rod part of the X body has the same properties as the plasma membrane while its vesicular part differs and is closer to the inner membrane system of the cell. In consequence it is suggested that the rod part of the X body is a specialized pathway or shuttle for receptor linked glycoprotein exchanges in highly specialized cells.

Benzothiazoles↗
PubMed1985

Anatomo-pathological findings in a case of combined deficiency of sulphite oxidase and xanthine oxidase with a defect of molybdenum cofactor.

A case of combined deficiency of sulphite-oxidase and xanthine-oxidase with a defect of the molybdenum cofactor, which is vital to the activity of sulphite-, xanthine- and aldehyde-oxidase, is reported here. Seven cases of combined deficiencies have been described with regard to both clinical and laboratory findings. The clinical, laboratory and anatomo-pathological features and, in particular, the central nervous system lesions of the present case correspond exactly to those in the case described Rosenblum in which an isolated deficiency in sulphite-oxidase was present. As the cerebral alterations in the present case are comparable to those described in Rosenblum's case, they probably result from the defect in sulphite-oxidase activity.

Amino Acid Metabolism, Inborn Errors↗
PubMed1985

Failure of histiocytosis X cells to express i blood group antigen.

Expression of HLADR, I, i blood group antigen and T6 antigen were studied in Histiocytosis X cells and pulmonary alveolar macrophages using double labelling immunofluorescence technique or immuno-peroxidase procedure. Alveolar macrophages express simultaneously HLADR and i blood group antigen. Histiocytosis X cells, characterized by HLADR and T6 antigens, and by their ultra-structural marker do not express i antigen. These results confirm the hypothesis that histiocytosis X cells constitute a specialized sub-population of the mononuclear phagocyte system.

Blood Group Antigens↗
PubMed1985

Hypercalcemic infantile renal tumors: morphological, clinical, and biological heterogeneity.

Hypercalcemic infantile renal tumors without bone metastases should be considered to be a heterogeneous tumoral entity. Histological and ultrastructural features, different from those of nephroblastoma, should not be exclusively linked with malignant rhabdoid tumors of the kidney. This is reported by the present case, which appears to be a cellular variant of mesoblastic nephroma and was successfully serially transplanted to nude mice. The causes of hypercalcemia in infantile renal tumors are probably related either to NH2-terminal parathormone or to prostaglandin E2 production by the tumoral cells.

Animals↗
PubMed1985

Hypertension induced by repeated exposure to high sustained +Gz (HS + Gz) stress.

The purpose of this study was to determine whether repeated exposure to high sustained +Gz (HS + Gz) stress induced persistent changes in the functional state of the cardiovascular system. Three groups of rabbits--centrifuged, restrained, and control--were studied. After being placed in the restraining system of the centrifuge, the animals were submitted three times in a row to 8-9 +Gz sustained for 40 s. This exposure was repeated three times a week for 3-6 weeks. Restrained animals were not exposed to HS + Gz. Control animals were not restrained. The two types of stress (centrifuge + restraint; restraint alone) determined the appearance of two types of arterial hypertension. Systolic arterial pressure (AP) and left ventricular pressure (LVP) significantly increased in restrained animals. The function of the cardiovascular system was more perturbed in centrifuged rabbits since the significant changes affected not only systolic AP and LVP but alos systemic diastolic AP and the maximum rate of rise of LVP. The myocardium of rabbits repeatedly subjected to HS + Gz exposures, except for those that suffered a fracture of the lumbar spine, was significantly glycogen-depleted.

Adenosine Diphosphate↗
PubMed1976

[Chyloperitoneum causing intestinal obstruction].

The two cases reported here show intestinal obstruction may occur by coagulation of lymph around the loops. They permit us to better understand the physiopathology of blockage of the lymph vessels whether congenital as in the first case or traumatic as in the second case. Traumatic rupture of the cisterns chyli is exceptional. The histological lesions observed on clamped biopsies show clearly the pathology of protein-losing enteropathy.

Adult↗
PubMedDate not supplied

[The state of bone tissue in monkeys in experiments in the Cosmos-1887 biosatellite].

Using invasive and noninvasive techniques, we studied bone changes in primates flown for 13 days on Cosmos-1887 and compared them with the data obtained from vivarium control animals and from the flown primates that were after flight exposed to a ground-based synchronous experiment in the biosatellite mockup. It was found that bone density in the diaphysis of the tibia decreased while its growth rate remained unchanged or diminished. Contact X-raying indicated a higher rate of endosteal resorption in the flown primates when compared with the controls. Histomorphometric measurements of iliac bioptates displayed signs of inhibited bone formation after flight. The above observations are discussed and compared with the results obtained in previous biosatellite flights and ground-based studies.

Animals↗
PubMedDate not supplied

[The induced hyperlipemia test. 10 years of experience].

The induced hyperlipemia test, which is easly to administer, yields very interesting information for the study of lipidic metabolism in arteriosclerosis patients. Its use, in both the pre- and post-operative phases, has brought out the valuable effect of ligature of the intestinal lymphatics in treating arteritis. It may also enable us to determine whether there is a hereditary factor or family predisposition to arteriosclerosis. Furthermore, the test makes it possible to confirm diagnosis of obstruction of the lymphatics of the gut in exsudative enteropathy and in various dysfunctious of the chyliferous vessels (sclerosis, rupture, tumoral invasion) without to resort to the use of radioactive substances.

Adult↗
PubMedDate not supplied

[Globoid cells leukodystrophy apropos of a case of Krabbe's disease].

A case of Krabbe's leucodystrophy is reported after photon and delayed ultrastructural microscopic study. Cerebroside overload within the cerebral globoid cells was shown as well as in the interstitial histiocytic infiltration of the peripheral nerves. Reviewed with the published literature, the characteristics of the inclusions observed seem to be unspecific and, from a morphological standpoint, Krabbe's disease may be related to the gangliosidoses.

Brain Diseases↗