PubMed Health⌕ Search

Biomedical subjects

C Nwokolo

Publications and source records attributed to C Nwokolo.

At least 19 recordsLinked to original sources
PubMed2002

The secret (GTN) of successful ERCP cannulation: a prospective randomised controlled study.

BACKGROUND: A key step for success at endoscopic retrograde cholangio-pancreatography (ERCP) is cannulation of the sphincter of Oddi. This prospective randomised controlled study was conducted to assess the effect of glyceryl trinitrate (GTN) on ease of cannulation. METHOD: Two hundred and fifty four patients undergoing ERCP were randomised into two groups, 126 controls and 128 pre-treated with GTN. RESULT: There were 29 cannulation failures in the whole group (overall failure rate of 11.4%). Failure was significantly less common in the GTN group, 7.03% (9/128) as compared with 15.8% (20/126) in the control group (p=0.0002). Deep cannulation was desired but not achieved in 45/200 patients (22.5%) Of these, 18.4% (19/103) were in the GTN group versus 26.8% (26/97) in the control group. This pattern of difference applied to both trained and trainee endoscopists. No significant side effects of GTN were noticed. CONCLUSION: GTN appears to be safe and effective in improving ERCP success rate. We recommend its routine use.

Aged↗
PubMed1986

Tropical diabetes.

Explore the source record for details and available documents.

Diabetes Mellitus↗
PubMed1980

Pathogenesis of juvenile tropical pancreatitis syndrome.

The name juvenile tropical pancreatitis syndrome (JTPS) is proposed for a disease which affects young people of both sexes in certain parts of the tropics and which is characterised by abdominal pain, diabetes, steatorrhoea, and pancreatic calcification. The condition seems to start with blockage of the pancreatic ducts by laminated secretions or inspissated mucus plugs which later calcify. Chronic pancreatitis follows. The hypothesis is that plugs are the result of pancreatic stasis due to prolonged lack of food in the stomach and/or gastroenteritis and dehydration. Most plugs are probably dislodged during convalescence when protein-containing foods are eaten and stimulate vigorous flow of pancreatic juice. The sluggish pancreatic flow produced by very-low-protein diets may not dislodge plugs. Repeated infection and anorexia can enlarge the plugs which ultimately calcify. JTPS therefore occurs in Third-World areas with a high rate of childhood infections, and where low-protein staples are taken. Cereal staples seem to reduce the incidence of JTPS in endemic areas because of their protein content.

Adolescent↗
PubMed1979

Diabetes after infectious hepatitis: a follow-up study.

Eleven patients (nine men, one woman, and one girl) aged 11-62 years who developed diabetes mellitus after an attack of infectious hepatitis during the Eastern Nigerian epidemic of 1970-2 were followed up for two to nine years. One patient aged 60 years remained diabetic after the original illness. In the remaining 10 patients the diabetes remitted after three to nine months (mean 6.7 months) but in four it recurred after a remission lasting one and a half to four years (mean 2.6 years). Results of this follow-up study seem to confirm that the pancreas is sometimes permanently damaged during infectious hepatitis.

Adult↗
PubMed1978

Aflatoxin load of common food in savanna and forest regions of Nigeria.

Aflatoxin, one of the most widespread of the known carcinogens, is present at a high level in most common foods stored poorly for long periods in Nigeria. It may work synergistically with other carcinogens to produce the high incidence of primary liver cancer seen in young men under the age of 40. In the northern savanna areas cereals, especially sorghum and millets, as well as groundnut products are the high risk foods. In the southern forest areas, dried fish, groundnuts and oil palm products often carry unwholesome quantities of aflatoxin. Public health measures aimed at reducing the aflatoxin load in high risk foods identified should now be actively considered.

Aflatoxins↗
PubMed1977

Single dose therapy of paragonimiasis with menichlopholan.

Menichlopholan, biphenyl compound, in a single dose of 2 mg/kg body weight, gave a 73%-90% cure rate in the treatment of pulmonary infections due to Paragonimus uterobilateralis at two centers in Nigeria. Ninety-five patients were followed up for 4 months, and 58 for 1 year. Side effects of the drug included sweating and body pains, but there was no significnat biochemical or hematological evidence of damage to the internal organs. The advantages of single dose therapy are likely to make menichlopholan the treatment of choice for paragonimiasis in Africa, and probably elsewhere.

Adolescent↗
PubMed1977

Cutaneous cladosporiosis due to Cladosporium trichoides.

A case of cutaneous cladosporiosis due to Cladosporium trichoides, manifesting as a chronic discharging ulcer near the wrist of the left arm in a farmer with ascites and hypoalbuminaemia is described. The isolate was neurotropic in experimentally infected mice. The present case constitutes one of the few reports of cutaneous cladosporiosis.

Adult↗
PubMed1974

Endemic paragonimiasis in Africa.

Human paragonimiasis has been recorded in 4 West African countries but there is clear evidence of endemicity only in certain parts of Nigeria and Cameroon. In Nigeria, the dominant parasite species is Paragonimus uterobilateralis, while in Cameroon it is P. africanus. Both the fresh water crab Sudanonautes africanus and the land crab S. aubryi are proved vectors in Nigeria. Epidemiological studies using Paragonimus skin tests suggest an infection rate of between 5% and 10% in some endemic areas. African paragonimiasis, like its Asian counterpart, responds well to treatment with bithionol.

Adolescent↗