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C O Samuelson

Publications and source records attributed to C O Samuelson.

41 records · Page 3Linked to original sources
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Hematologic and serologic studies in 6-sulfanilamidoindazole arthritis.

6-sulfanilamidoindazole (6-SAI), an antibacterial sulfonamide, is known to cause an acute, self-limited inflammatory reaction in the hind paws of older rats. Administration of 6-SAI results in hyperfibrinogenemia which precedes the onset of clinical arthritis. The hyperfibrinogenemia is associated with the prolongation of dilute blood clot lysis times, appearance of heparin-precipitable fibrinogen, elevations in fibrin degradation products, and complement titers and serum electrophoretic pattern changes that consist of decreased albumin concentrations and increased beta globulin concentrations. Alterations in 6-SAI medicated young rats are less marked and require higher doses.

Administration, Oral↗
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Acute joint pain.

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Acute Disease↗
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Normal erythrocyte sedimentation rate with hyperfibrinogenemia in 6-sulfanilamidoindazole arthritis.

The erythrocyte sedimentation rate (ESR) is the most frequently employed laboratory indicator of inflammatory activity. The plasma fibrinogen concentration is usually increased in inflammatory disorders and is thought to contribute to the ESR elevation, 6-sulfanilamidoindazole induced arthritis in rats produces very high plasma fibrinogen concentrations and increased blood viscosity but no change in ESR.

Animals↗
PubMedDate not supplied

Articular complications of jejunoileal bypass surgery.

Articular complications are now frequently recognized with jejunoileal-bypass surgery for morbid obesity. We have evaluated 6 referred patients with these problems and 50 consecutive patients who had this procedure. The arthritis is variable but usually affects multiple joints. Four patients were seen during acute attacks of arthritis and all had cryoprecipitable material in their sera and plasma. Three of these 4 patients had evidence of Group D streptococcal antigen present while their joint disease was active, suggesting a possible role for bacterial antigens in the pathogenesis of the arthritis of jejunoileal bypass.

Adult↗