Biomedical subjects

C Osorio-Salazar

Publications and source records attributed to C Osorio-Salazar.

3 recordsLinked to original sources

PubMed1995

Effects of suppressive doses of levothyroxine treatment on sex-hormone-binding globulin and bone metabolism.

The adverse effects of suppressive thyroxine treatment have previously been investigated and conflicting results have been published. This study aimed at evaluating the effects of subclinical hyperthyroidism on the liver and bones. We investigated the action of thyroxine on the liver by measuring sex-hormone-binding globulin (SHBG) levels and on bone turnover by evaluating osteocalcin (BGP) in both pre- and postmenopausal women. We compared the levels of both proteins to those of untreated subjects matched for age, menopausal status, and weight. Bone mineral density (BMD) was evaluated by biphotonic absorptiometry only in postmenopausal women with estrogen replacement therapy (ERT) and compared to two postmenopausal estrogen-treated controls. Forty-five women with multinodular goiter (38) or postsurgical thyroid carcinoma (7) were studied. They had received LT4 for 3 to 5 years (150 +/- 34 micrograms/day for nontoxic multinodular goiter, 184 +/- 46 micrograms/day for thyroid carcinoma). All patients had normal free T3 concentrations. No significant difference was found in SHBG values between patients and controls whatever the menopausal status and the BMI; a significant increase in BGP was noted in premenopausal women (9.6 +/- 2.2 vs 6.7 +/- 2.3 ng/ml; p < 0.0006). No significant BGP and BMD variations were observed in treated postmenopausal women. In summary, the study of carefully matched patients and controls revealed that thyroxine treatment has no effect on SHBG levels.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1994

[Basedow disease following autoimmune primary hypothyroidism. Apropos of 7 cases].

The evolution of Graves' disease following auto immune hypothyroidism appears to be rather infrequent. We present seven female patients with autoimmune thyroiditis, 2 with goiter and 5 with hypothyroidism who, after a few months or years, presented signs of Graves'. Therefore it is usefull to carefully monitor TSH in patients treated for autoimmune thyroiditis to detect a possible evolution towards Graves' disease. This should be mostly true in patients with TBII positive antibodies autoimmune thyroiditis. During hyperthyroidism, 123 lodine uptake is much lower than usually observed in Graves' nevertheless, it is always increased compared to the uptake measured during hypothyroidism. This could be in favor of residual functional capacity of these often small thyroid glands. The alternate action of blocking or stimulating antibodies upon the TSH receptor would probably explained the switch from hypo to hyperthyroidism, even if there is usually no correlation between antibodies levels and clinical signs.

Adolescent↗

PubMedDate not supplied

Experience with immunoglobulins in thyroid autoimmunity.

The physiopathology of Graves' ophthalmopathy is poorly understood. Therefore, the best treatment of Graves' ophthalmopathy is still a matter of debate. Steroids, X-ray therapy, surgery and more recently cyclosporine, plasma exchange and somatostatine analogs have been tried. There is no doubt that we are dealing with an autoimmune process. The use of immunoglobulins has been shown to be safe and efficient.

Adrenal Cortex Hormones↗