Biomedical subjects
C P Barsano
Publications and source records attributed to C P Barsano.
The effect of thyroid hormone on in vitro rat liver mitochondrial RNA synthesis.
Liver mitochondrial preparations from normal, thyroidectomized, and triiodothyronine-treated thyroidectomized rats were assayed for in vitro RNA synthetic activity. Thyroidectomized rat mitochondrial preparations incorporated UTP into RNA at 70% the rate of normal control preparations. Mitochondrial preparations from triiodothyronine-treated thyroidectomized rats incorporated UTP at rates 35%-45% greater than those of sham-injected thyroidectomized rats. These differences were statistically significant and could not be attributed to inequalities in mitochondrial sampling, dilution of labeled precursor specific activity, nucleotide substrate concentrations, or differences in ribonuclease activities.
Endocrine disorders of occupational and environmental origin.
Many compounds used and produced in industry are potentially toxic to the endocrine system. The importance of medical surveillance in the workplace is emphasized in light of the increasing numbers of women in industry and the associated potential reproductive risks. Endocrine-toxic compounds also can gain wider access to entire communities through designed release to the environment (as with pesticides), accident, or disposal of toxic waste. The mechanisms of various industrial toxins in causing disease of the thyroid, testes and ovary, and pancreas are reviewed.