Biomedical subjects

C P Hibler

Publications and source records attributed to C P Hibler.

At least 19 recordsLinked to original sources

PubMed2001

Radiculomeningomyelitis due to Halicephalobus gingivalis in a horse.

An adult horse was euthanatized following a clinical diagnosis of cauda equina neuritis. Significant gross postmortem and histopathologic findings were limited to the sacral spinal cord and cauda equina. The sacral spinal cord, meninges, and spinal nerve roots were expanded and partially effaced by sclerosing granulomatous inflammation with necrosis. The lesion contained numerous nematode larvae and fewer adults with a rhabditiform esophagus having a corpus, isthmus, and valved bulb. Female nematodes were amphidelphic and didelphic with reflexed ovaries. These morphologic features confirm Halicephalobus gingivalis as a novel cause of clinical signs in this case of cauda equina neuritis.

Animals↗

PubMed1987

Prevalence of Giardia sp. in a beaver colony and the resulting environmental contamination.

The prevalence of Giardia sp. in a beaver (Castor canadensis) colony in Colorado was determined by the collection and analysis of fecal samples over a period of 14 mo. Environmental contamination was monitored through the use and analysis of water filter samples. Beaver shed cysts of Giardia sp. in their feces throughout the year with temporal variations in the prevalence, and became infected as kits and remained infected as juveniles and adults. Beaver served as amplification hosts for Giardia sp. and contaminated surface waters downstream from their dams in late spring and early fall. In slow moving waters the cysts of Giardia sp. settled rapidly. Muskrats (Ondatra zibethicus) were the only other species of wildlife shedding cysts of Giardia sp. on the study area.

Animals↗

PubMed1984

Pathologic changes and microorganisms found in bighorn sheep during a stress-related die-off.

An all-age die-off of Rocky Mountain bighorn sheep (Ovis c. canadensis Shaw) occurred from late October 1980 through March 1981 in Waterton Canyon, Colorado, with a loss of 75 to 85% of the sheep. The cause of death was a subacute to chronic bronchopneumonia and the primary etiologic agents isolated from the respiratory system were a Pasteurella sp., P. multocida, Corynebacterium pyogenes, and Protostrongylus stilesi Dikmans, 1931. The underlying predisposing factors that initiated this die-off were believed to be related to multiple chronic environmental stressors associated with the building of a dam which included human contact, vehicular traffic, atmospheric dust, noise and harassment. The die-off was succeeded by a 100% lamb mortality the following summer and a 67% lamb mortality the next two summers. The pneumonia found in these lambs was similar to that found in adult sheep during the previous die-off, except that mature lungworms were absent.

Animals↗

PubMed1983

Experimental contagious ecthyma in mule deer, white-tailed deer, pronghorn and wapiti.

Hand-reared mule deer fawns (Odocoileus hemionus), white-tailed deer fawns (Odocoileus virginianus), pronghorn fawns (Antilocapra americana) and wapiti calves (Cervus elaphus nelsoni) were exposed to contagious ecthyma lesion material obtained from Rocky Mountain bighorn sheep (Ovis canadensis canadensis) to determine the susceptibility and pathogenesis in these species. All four species developed mucocutaneous proliferative lesions of the oral cavity, grossly and histologically compatible with contagious ecthyma. The limited clinical responses to the virus indicated that contagious ecthyma would not seriously impact free-ranging individuals.

Animals↗

PubMed1982

Oral administration of diazepam and promazine hydrochloride to immobilize pronghorn.

Oral tranquilizers were mixed with a grain bait and fed to pronghorn (Antilocapra americana) in an attempt to immobilize and thus facilitate their capture. Diazepam, administered at 6 mg/kg body weight immobilized a tame pronghorn fawn within 30 min. Tranquilization was still apparent after 8 h. A minimum dose of 23 mg/kg body weight was necessary to immobilize a wild adult pronghorn. Immobilization occurred after 60 min and tranquilization was apparent 24 h post ingestion. Excitement severely impeded the effect of the drug and although easily captured, the animal struggled wildly when handled. Wild pronghorn fawns showed moderate tranquilization when administered diazepam at 23 mg/kg body weight but were unapproachable. Doses of diazepam between 13 and 23 mg/kg body weight were used to capture tame yearling and adult pronghorn held in a 132 ha enclosure. A dose of 23 mg/kg body weight was excessive in that the animals did not recover for 48 to 54 h post ingestion and had difficulty maintaining a sternal bedding position. Diazepam at 13 mg/kg body weight failed to tranquilize the animals sufficiently for easy capture. Promazine hydrochloride at doses of 2 to 17 mg/kg body weight, given orally to wild pronghorn fawns and an adult, did not produce visible signs of tranquilization. Animals refused to eat bait containing doses of promazine hydrochloride greater than 17 mg/kg body weight.

Administration, Oral↗

PubMed1980

Experimental infection of mule deer with Parelaphostrongylus tenuis.

Six adult and three fawn mule deer (Odocoileus hemionus) were experimentally infected with a range of 75-100 infective larvae of Parelaphostrongylus tenuis. Five of the six adult deer developed clinical signs of neurologic disease that terminated in paralysis between 35 and 80 days. The sixth deer developed slight signs of neurologic disease for 10 days, but recovered. All three mule deer fawns developed neurologic disease. Adult meningeal worms were recovered from the subdural space of the spinal cord of two fawns. Eggs were observed on the cranial dura mater of one of these fawns, indicating that P. tenuis can complete its life cycle provided mule deer can survive the damage resulting from the infection. Neither eggs nor larvae of P. tenuis were recovered from the feces or lungs of infected mule deer. Clinical signs and histologic lesions observed in experimentally infected mule deer resembled those reported in infected moose (Alces alces americana). Two critical periods were apparent in mule deer infected with P. tenuis: nematode migration through the spinal neural parenchyma, and penetration of the adult nematodes into the cranial neural parenchyma. While most adult deer were unable to survive the first critical period, fawns survived the first but succumbed to infection during the second critical period.

Animals↗

PubMed1979

Experimental infection of white-tailed deer with Elaeophora schneideri.

An attempt was made to infect fawn and adult white-tailed deer, Odocoileus virginianus, with Elaeophora schneideri. Experimental infection of fawns caused a relative eosinophilia that persisted. Obstruction of a coronary artery caused death of one fawn, and weakness, dyspnea, and locomotor difficulties were observed in another fawn and an adult. Plaque-like lesions were observed grossly in the intimal lining of carotid arteries, and subintimal thickening and proliferation of fibrous tissue in vessel walls were observed microscopically. Nematodes were recovered from 3 of 4 fawns and 0 of 4 adults, suggesting an age-related resistance in older animals. Microfilariae were recovered via facial skin biopsy of a single fawn. This study suggests that white-tailed deer serve as usual hosts for E. schneideri, although the host-parasite relationship may be tenuous.

Animals↗

PubMed1977

A communitywide outbreak of giardiasis with evidence of transmission by a municipal water supply.

Three hundred fifty residents of Rome, New York, had laboratory-confirmed cases of giardiasis between 1 November 1974 and 7 June 1975. A random household survey showed an overall attack rate for giardiasis (defined as a diarrheal illness of 5 days or more) of 10.6%. A significant association was discovered between having giardiasis and using city water and between having illness and drinking 1 or more glasses of water a day. The presence of human settlements in the Rome watershed area suggested that the water supply could have been contaminated by untreated human waste. The infectivity of municipal water was confirmed by producing giardiasis in specific pathogen-free dogs fed sediment samples of raw water obtained from an inlet of a city reservoir. A microscopic examination of the water sediments uncovered a Giardia lamblia cyst in one sample. This was the first time that a G. lamblia cyst has been found in municipal water in an epidemic and the first time that such water has been shown to infect laboratory animals.

Animals↗

PubMed1976