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Biomedical subjects

C P Lyman

Publications and source records attributed to C P Lyman.

17 recordsLinked to original sources
PubMed1988

A pharmacological study of hibernation in rodents.

1. Hamsters and ground squirrels in deep hibernation were infused intra-arterially with drugs. 2. Norepinephrine and epinephrine sometimes caused arousal, sometimes transitory effects. 3. Adrenalectomy did not affect arousal. L-DOPA and amphetamine produced a slow arousal. 4. Arousal was blocked with alpha-methyltyrosine and the block was released with L-DOPA, DL- and L-threo-DOPS resulted in arousal and bromocriptine did not cause arousal, indicating that dopamine was not necessary for arousal. 5. Isoproterenol caused a transient increase in heart rate which was blocked by propranolol. 6. Phenylephrine caused vasoconstriction, but did not result in arousal. 7. No drug increased the sensitivity to peripheral stimuli during hibernation.

Adrenalectomy↗
PubMed1982

Lipofuscin accumulation and hibernation in the Turkish hamster, Mesocricetus brandti.

This report is based on previous data that showed that Turkish hamsters that hibernated lived longer than nonhibernating controls. Fluorescent microscopy was used to measure the lipofuscin content of brain and heart of hamsters that hibernated for various fractions of their lives. According to regression data the 13 animals that hibernated 11 to 37% of their lives had a slower accumulation of lipofuscin than 11 animals that hibernated 0 to 7% of their lives. It was calculated that the total amount of pigment accumulated during a life span was the same in both groups, in spite of the longer life of the hibernators.

Animals↗