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Biomedical subjects

C P Singh

Publications and source records attributed to C P Singh.

At least 19 recordsLinked to original sources
PubMed1993

Efficacy of ciprofloxacin and norfloxacin in multidrug resistant enteric fever in adults.

Twenty-five out of 55 patients of enteric fever were documented as multidrug resistant enteric fever cases. In the resistant cases the drug sensitivity of salmonella species in vitro were mainly augmentin, ceftriaxone, aminoglycosides, ciprofloxacin and norfloxacin. Sixteen patients were treated with ciprofloxacin and 9 were treated with norfloxacin for 14 days. Fever touched normal in 62.5% cases with ciprofloxacin and in 33.3% cases with norfloxacin by the 7th day. It became normal in 88% with ciprofloxacin and in 66% with norfloxacin by the 10th day and it became normal in 100% cases in each group by the 14th day. The newer 4-quinolones can be recommended in multidrug resistant enteric fever in adults.

Adolescent↗
PubMed1992

Correlative effects of quinidine on ECG pattern and serum cholesterol concentration in Acridotheres tristis.

Antiarrhythmic drug quinidine, administered daily at the rate of 10 mg/kg for 7 days in A. tristis produced an increasing effect on the amplitude and duration of different waves and intervals. Heart rate was decreased from 478.40 to 444.47 beats/min. Serum cholesterol level was reduced from 86 to 54.30 mg/100 ml. The data of the effect of quinidine on the ECG pattern and serum cholesterol were analysed and the values of the correlation coefficient and their significance were computed. The values of the correlation coefficient computed between the level of serum cholesterol (Y) and P-R interval (X) comes out to be significant at 5% level of significance. A linear regression line Y on X was fitted to the above data and the line is found to be: Y = 2535.897 X -62.858. This regression line may be used to determine the level of serum cholesterol on the basis of changes in the P-R interval of the ECG tracing in the quinidine treated birds.

Animals↗
PubMed1991

Effect of propranolol on ECG of Myna, Acridotheres tristis, and Goh, Varanus bengalensis.

Effect of propranolol (1 and 3 mg/kg body wt), a sympathetic blocking agent, on ECG patterns was studied in Varanus and Acridotheres. ECG was recorded before and after 5 min (immediate), 15 min and in some cases 25 min of drug infusion. All animals responded to propranolol with bradycardia. The effectiveness is dose dependent and it is also associated with the high heart rate both in Acridotheres and in Varanus. The P-R or P-S interval increased in all cases of Varanus after infusion. In Acridotheres height and duration of P-wave were increased slightly with the lower dose and decreased with the higher dose. The Q-S shortened with the lower dose and widened late with the higher dose in Varanus whereas in Acridotheres it is widened with lower and higher doses of propranolol. The Q-T interval has been increased in both groups of animals. An increased amplitude of T-wave height was observed in Varanus after 5 and 15 min of drug infusion. But it was noted with decrease in amplitude under high dose after 15 min of drug infusion. In Acridotheres it was on increase with lower dose and decrease with higher dose. The delta-wave disappeared after the administration of propranolol in Acridotheres.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1982

Histopathological changes in different tissues of T. fasciatus under the acute impact of BHC.

The acute toxic effect of BHC on gills, liver, stomach and intestine of a fresh water teleost, Trichogaster fasciatus, has shown pathological changes after exposure to a sublethal (1.5 ppm) and a lethal (3.6 ppm) concentration of the toxicant for 24 and 96 h. Damage to the different tissues was more pronounced in a lethal concentration of the chemical and increased time of treatment. The gills exhibited greater damage compared with the liver, stomach and intestine. Swelling of the secondary lamellae leading to the detachment of the epithelium from the pillar-cell system (PS) and its partial degeneration with loss of rigidity of the PS and hypertrophy in the lamellar channels were the major changes induced. In the liver, the tissue showed prominent splitting (SP) due to the widening of the sinusoids. The cells lost their shape, the membrane was ruptured, the cytoplasm became granulated and necrosis was evident. Degeneration of the epithelium (EP), shrinkage and atrophy in the tunica propria (TUP) and vacuolation (VA) in different layers of the stomach and intestine were also observed.

Animals↗
PubMedDate not supplied

Degradation of lignocellulosic material and humus formation by fungi.

Cellulase activity and degradation of cellulose and lignin in wheat straw and formation of humus during degradation by Aspergillus sp., Chaetomium globosum, Fusarium solani, Paecilomyces varioti, Penicillium chrysogenum and Trichoderma viride QM9414 were studied. C. globosum, F. solani, P. varioti and P. chrysogenum produced little or no cellulase when grown on cellulose powder. However, all produced cellulase (filter paper degrading activity) when grown on wheat straw. All the cultures degraded cellulose and lignin to some extent, but P. varioti was the most efficient in cellulose and lignin degradation. There was an increase in humus-like substances after inoculation with fungi.

Cellulase↗
PubMedDate not supplied

Solubilization of insoluble phosphates by thermophilic fungi.

The solubilization of tricalcium phosphate and rock phosphate and assimilation of solubilized P by thermophilic fungi isolated from compost were studied. The solubilization of tricalcium phosphate was greater than that of rock phosphate on inoculation with fungi in liquid medium, but growth of most of the fungi was greater in rock phosphate. Torula thermophila solubilized tricalcium phosphate maximally. There was solubilization of rock phosphate in semi-solid lignocellulose medium by Aspergillus fumigatus.

Fungi↗