[Larsen syndrome and idiopathic hypercalciuria].
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Biomedical subjects
Publications and source records attributed to C Pérez Prado.
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A study of the pediatric infections due to group D streptococci, based on the causist of the Pediatric Department of the School of Medicine at Barcelona is performed. It comprises 20 cases of newborn sepsis (one of them with meningitis), and nine urinary infections in children of several ages. The isolated straws, that pertained all to "enterococcus", revealed greatest sensibility in decreasing order to ampicillin, carbenicillin, chloramphenicol, furantoin and gentamicin. In neonatal sepsis the beginning was precocious in 50% of the cases, the frequency of newborns with low birth weight was high (35%), and the course was favourable in 95%; the only case that died was affected of meningitis with pyocephalia. Urinary infections prevailed in the first year of life (44%), but all the affected were older than a month of life. There were characterized by little accused symptomatology, and quickly favourable course of the infection, through adequate antibiotic treatment. Nevertheless, the long term prognosis is darkened by severe renal and urinary malformations that were appreciated in 55% of the patients.
This case deals with a 15-month old male child affected with a nephrotic syndrome resulting in grave chronic renal failure, determined histologically as diffuse mesangial sclerosis. The most frequent causes of nephrotic syndrome in the first year of life are analyzed along wiht their diagnostic differential, with special attention to the Finish or microcystic congenital nephrotic syndrome and to diffuse mesangial sclerosis. In the discussion contradictions existing in the bibliography on diffuse mesangial sclerosis are shown in its clinical and developmental aspects as well as the prognostic and even in the pathological anatomy, which leads us to believe that this illness may be more complex than what it appears, and subdividing it into illnesses of different etiology, development and prognosis; or that some of the cases. described as such may not be the same as those described by R. Habib in 1973. In the present case the deposits of C3 and IgM are worth noting, as they were not described in the other 11 cases, also the study done with the electron microscope, which also was not done in the previous cases.
A case of primary protrusion of the acetabulum in a ten year old girl, is presented. A review of the tiology, history, clinical signs and treatment is done. Authors comment the influence of genetic factor in the mother and the father, in the clinical picture of their patient.