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Biomedical subjects

C Palermo

Publications and source records attributed to C Palermo.

23 records · Page 2Linked to original sources
PubMed1983

[Serum ferritin in rheumatoid arthritis: an acute phase protein or indication of iron deposits?].

Serum ferritin was determined in 24 menopausal women who did not have any iron metabolic disorders but were suffering from RA. We furthermore investigated its correlation to various clinical and laboratory indexes of activity. The regression analysis revealed significant coefficients of direct correlation between serum ferritin, ESR, and Ritchie's index as well as an indirect correlation to the hematic haemoglobin and to serum iron. These data would apparently be in agreement with the hypothesis that, during the course of RA, serum ferritin assumes the significance of an acute phase protein; nonetheless, in spite of this, these data would induce one to believe that the serum ferritin levels closely reflect that RES iron deposits, the extent of which is influenced by chronic phlogosis.

Adult↗
PubMed1983

[Sideropenic anemia in rheumatoid arthritis: diagnostic usefulness of serum ferritin, unsaturated transferrin and induced urinary siderosis].

The various erythrocyte indices, serum iron, unsaturated iron binding capacity, serum ferritin and sideruria after desferrioxamine were measured in a group of 30 patients with active Rheumatoid Arthritis and anemia. The patients were subdivided into two groups of 23 and 7 subjects based on the presence or absence of marrow iron stores, respectively. Significant differences in the mean values of unsaturated iron binding capacity (P less than 0.001), serum ferritin (P less than 0.01) and sideruria after desferrioxamine (P less than 0.001) were observed between the two groups of patients by statistical analysis. Unlike the other indices, the values assessed in the first and the second group of patients as for the above parameters did not overlap. A negative correlation index and a positive one of high significance (P less than 0.001) was found between the values of serum ferritin and those of unsaturated iron binding capacity and sideruria after desferrioxamine, respectively. The above results demonstrate that even in active Rheumatoid Arthritis a concomitant iron deficiency can be diagnosed by means of non-invasive, quantitative and easily reproducible methods.

Anemia, Hypochromic↗
PubMedDate not supplied

Relationship between serum ferritin, iron stores and disease activity in rheumatoid arthritis.

Bone marrow aspirate from the sternum of 40 patients with active or inactive rheumatoid arthritis (RA) was stained with Perls' Prussian blue for iron determination. In these patients serum ferritin concentrations were correlated with other indices of iron stores and disease activity. In patients with active RA and without bone marrow iron stores, serum ferritin was significantly lower than in patients with either active or inactive RA and iron stores. In patients with bone marrow iron stores, serum ferritin was directly correlated with erythrocyte sedimentation rate (ESR), Ritchie index, alpha 1-antitrypsin, alpha 1-acid glycoprotein and desferrioxamine (DFO)-induced sideruria, while an inverse correlation of serum ferritin with hemoglobin and serum iron was observed. In all patients serum ferritin was significantly correlated only with DFO-induced sideruria and unsaturated iron-binding capacity (UIBC). Thus, serum ferritin is an index of iron stores also in rheumatoid arthritis. In active disease, higher than expected values of serum ferritin are probably due to a shifting of iron from the circulating pool to the reticuloendothelial cells of the synovial membrane.

Adult↗
PubMedDate not supplied

FMS*Calciumfluor increases alkaline phosphatase expression during osteogenesis in vitro of tibia-derived rat osteoblasts by activation of G alpha 0/G alpha i proteins.

We studied the involvement of G-proteins in transducing the inductive signal generated by treatment of tibial-derived neonatal rat osteoblasts (ROB) cultured in vitro with FMS*Calciumfluor, a homeopathic preparation utilized in the therapy of osteoporosis. We previously reported that FMS*Calciumfluor acts as inducer and potentiator of osteogenic differentiation in vitro, among other effects, by increasing the expression of Alkaline phosphatase (AP). We utilized Pertussis Toxin (PTX), an inhibitor of G alpha 0/G alpha i proteins, Mastoparan 7, an activator of G alpha 0/G alpha i proteins and Cholera Toxin (CTX), a stimulator of G alpha s protein to show involvement of specific G proteins in the inductive effect on AP of FMS*Calciumfluor. We here show that the increase in AP expression induced by FMS*Calciumfluor is dependent on the activation of G alpha 0/G alpha i proteins, while it is unaffected by the activation stage of the G alpha s protein. Moreover, we show that the expression of endogenous AP during osteogenesis in vitro is regulated independently from G proteins, and unaffected by their activation stage and therefore that treatment with FMS*Calciumfluor activates a new pathway of cellular response.

Alkaline Phosphatase↗