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Biomedical subjects

C Papadopoulos

Publications and source records attributed to C Papadopoulos.

12 recordsLinked to original sources
PubMed1992

Intravenous atenolol in elderly patients in the early phase of acute myocardial infarction.

The aim of this study was to assess the hemodynamic response to intravenous atenolol in elderly patients with acute myocardial infarction. We studied 14 elderly men, aged 64-85 years, and 14 younger men, aged 29-48 years, in the early postfibrinolytic phase of acute myocardial infarction. All the patients were in Killip class I. A triple-lumen Swan-Ganz thermodilution catheter was introduced into the right heart chambers. The patients received 5 mg intravenous atenolol over 5 minutes. All hemodynamic parameters were measured before and 10 minutes after atenolol. The hemodynamic characteristics and the location and extent of acute myocardial infarction were the same in both groups before atenolol. The hemodynamic changes after atenolol administration were the same in the two groups, but the stroke volume and cardiac indexes decreased to a greater extent in the elderly (p = .01 and p = .0001, respectively). These results indicate that intravenous atenolol in the early postfibrinolytic phase of acute myocardial infarction is safe in Killip class I elderly patients, although the cardiac and stroke volume indexes decrease, and the increase in the total systemic resistance is more in older than in younger patients.

Adult↗
PubMed1991

Comparison of Q with non-Q myocardial infarction using signal averaged ECG.

Forty consecutive patients (pts) with acute myocardial infarction (MI) who survived to be discharged from the hospital were studied with high gain signal averaged electrocardiography (SAECG). 28% of the pts with non-Q MI had an abnormal SAECG as compared to 15% in the Q MI group. It was also found that SAECG showed a significantly longer filtering QRS duration in the non-Q MI group. The results above were considered as indicative of more delayed activation in pts with non-Q MI providing probably a substrate for more frequent reentrant arrhythmias.

Electrocardiography↗
PubMed1990

Tissue reaction to deep cuff of Tenckhoff's catheter and peritonitis.

To define the type of reaction around the deep cuff of Tenckhoff catheters and possible implications in peritonitis development, a histological evaluation of the tissue reaction around and into the deep cuff was done. Eight catheters, functioning for 2 to 40 months and removed for various reasons were studied. In all cases foreign body granulomata and fibrosis were found, with prominent giant cell formation. An inert birefrigent material, probably dacron particles, was found surrounded by giant cells in fibrotic regions and in some cases appearing as cytoplasmic inclusions. In 6 cases an inflammatory infiltration was observed, while in 4 with relapsing peritonitis, polymorphonuclears and microabscesses were also found. It can be suggested that the tissue reaction to deep cuff predisposes to local infections and might be a factor for relapsing peritonitis.

Adult↗
PubMed1989

The influence of piracetam on digoxin up-take by different rabbit tissues in vitro.

The action of increasing piracetam concentration on the digoxin up-take by various rabbit tissues was investigated in vitro. 125J-digoxin was used and radioactivity was counted in a gamma scintillation counter. Piracetam 100 micrograms/ml has a small increasing action on digoxin up-take by parenchymatous rabbit tissues. This action may be due to the beneficial effect of the substance on tissue microcirculation and cell metabolism. This action is equilibrated or reversed by piracetam 200 micrograms/ml and 400 micrograms/ml. It is suggested that piracetam displays digoxin from its binding-sites but these concentrations are above those ones used for clinical purposes.

Animals↗
PubMed1986

Sexual activity after coronary bypass surgery.

Although successful rehabilitation of coronary artery bypass surgery (CABS) patients should include consideration of their sexuality, there is a paucity of data regarding their sexual activity (SA). One hundred thirty-four patients were interviewed in regard to the impact of surgery on their sexuality and the relation of SA to their work status. Eighty-four of the 92 previously sexually active patients and two of the inactive ones resumed SA. Sexual dissatisfaction prior to surgery was a negative factor (p less than .05), while return to work, in the group that was working before, was positive (p less than .05) for resumption of SA. The average time before resumption of SA after CABS was 7.8 weeks. Thirty-nine percent of patients decreased the frequency of SA. Seventeen percent of patients and 35 percent of their partners expressed fear of resumption of SA. Twenty-three percent of patients had symptoms during intercourse. The couples who resumed sexual activity had a closer emotional relationship (p less than .02). Two-thirds of the patients received sexual instructions, but in only 20 percent of the cases did the physician himself initiate discussion. Although after CABS patients fare much better in regard to SA when compared to myocardial infarction patients reported in other studies, CABS does not provide a net gain in SA and sexual functioning. Comprehensive sexual counseling is still not being adequately addressed.

Adult↗
PubMed1985

A comparative trial of 400 mg cimetidine twice daily and 1000 mg daily in the short-term treatment of duodenal ulceration.

The therapeutic efficacy of cimetidine given as 400 mg twice daily was compared to that of cimetidine given as 1.0 g daily in 4 divided doses (200 mg 3-times daily and 400 mg at night) in two groups of 25 patients (total 50 patients) with active duodenal ulceration. After 4 weeks, healing rates of 72% and 76%, respectively, were observed for the two dosage regimens. Patients who remained unhealed at 4 weeks were treated for a further 4 weeks, after which cumulative healing rates of 84% and 92%, respectively, were obtained. None of the observed differences in healing rates were statistically significant. Symptomatic improvement was similar for the two dosage regimens. No significant adverse reactions were reported.

Adult↗