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C Partensky

Publications and source records attributed to C Partensky.

At least 55 records · Page 3Linked to original sources
PubMed1998

Necrolytic migratory erythema, first symptom of a malignant glucagonoma: treatment by long-acting somatostatin and surgical resection. Report of three cases.

We report three cases of malignant glucagonoma with necrolytic migratory erythema as the first clinical symptom. Long-acting somatostatin analogue was the first step of a multimodal therapeutic strategy which included surgical resection of the primary tumour in every case. Liver metastases which were present in two patients were treated by hepatic arterial chemoembolization and systemic chemotherapy in one case and by liver resection for cytoreduction and hepatic arterial chemoembolization in another case. Skin lesions resolved in all three patients.

Aged↗
PubMed1998

[Pancreatectomy after neoadjuvant chemoradiotherapy for potentially resectable exocrine adenocarcinoma of the pancreas].

The last of the therapeutic modalities proposed for exocrine adenocarcinoma of the pancreas which appears to be potentially resectable, neoadjuvant chemoradiotherapy has many prerequisites: validation of the diagnosis, determination of resectability with a high degree of confidence and palliation of biliary obstruction when present. This rather complex strategy does not seem to have major deleterious effects on the operative procedure or the postoperative course. Only multicentric protocols will, in the near future, give an answer to the question of secondary toxic effects and improvement of survival of this new therapeutic strategy.

Adenocarcinoma↗
PubMed1998

An IARC evaluation of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans as risk factors in human carcinogenesis.

The International Agency for Research on Cancer (IARC) Monographs program reevaluated polychlorinated dibenzo-p-dioxins and evaluated polychlorinated dibenzofurans as possible carcinogenic hazards to humans in February 1997, using the most recent epidemiologic data on exposed human populations, experimental carcinogenicity bioassays in laboratory animals, and supporting evidence on relevant mechanisms of carcinogenesis. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) was evaluated as carcinogenic to humans (IARC group 1 classification) on the basis of limited evidence of carcinogenicity to humans derived from follow-up of workers who had been heavily exposed in industrial accidents and sufficient evidence of carcinogenicity in experimental animals. The evaluation also considered the following supporting evidence: TCDD is a multisite carcinogen in experimental animals and has been shown by several lines of evidence to act through a mechanism involving the aryl hydrocarbon receptor; this receptor is highly conserved in an evolutionary sense and functions the same way in humans as in experimental animals; tissue concentrations of TCDD are similar in heavily exposed human populations in which an increased overall cancer risk was observed and in exposed rats that developed tumors in carcinogenicity tests. Other polychlorinated dibenzo-p-dioxins, the nonchlorinated dibenzo-p-dioxin, and polychlorinated dibenzofurans were evaluated as not classifiable as to their carcinogenicity to humans (group 3).

Animals↗
PubMed1998

[Treatment of hilar cancers].

Therapy of hilar cholangiocarcinoma is more clearly defined since progress in imaging allows accurate pretherapeutic work-up. The part of aggressive surgical resection which most of the time is a rather complex procedure is now well established since it is the only therapy which offers the chance of prolonged survival and sometimes cure. Palliative therapy which attempts to restore the bile flow is managed either conservatively by insertion of biliary endoprostheses using the percutaneous or the endoscopic approach or by intrahepatic biliary by-pass. Modalities of resectional surgery depends on the extent of the tumor. Orthotopic liver transplantation has only few selected indications because of the frequency of recurrence. Adjuvant therapy by external irradiation and chemoradiotherapy has been disappointing.

Bile↗
PubMed1997

Primary hepatocellular carcinoma in workers exposed to vinyl chloride: a report of two cases.

BACKGROUND: Vinyl chloride (VC), an industrial toxic gas, has a dose-dependent carcinogenicity in rodents and has been responsible for multiple cases of liver angiosarcoma in humans. The aim of this study was to describe histopathologic liver alterations and to evaluate risk factors for hepatocellular carcinoma in two workers from the same plant, both of whom had primary nonangiosarcoma liver tumors and were exposed to VC. METHODS: Clinical, biochemical, serologic, and pathologic data were reviewed at the time of hepatic resection. Clinical and biologic follow-up were available for several years before the diagnosis of hepatocellular carcinoma. RESULTS: Liver alterations distant from the tumor site were compatible with ongoing exposure to VC in both cases. Several areas containing dysplastic hepatocytes were present in nontumoral liver in one patient. Both patients are alive after partial liver resection, and 1 has had 5 years of follow-up without recurrence. CONCLUSIONS: Exclusion of classic risk factors for noncirrhotic hepatocellular carcinoma of the liver in both patients suggests a relationship between VC exposure and observed tumors. Systematic long term follow-up with biology and ultrasonography for workers exposed to VC may result in relatively early diagnoses of liver tumors and long term survival in some cases.

Carcinoma, Hepatocellular↗
PubMed1997

[Role of adjuvant chemoradiotherapy in the therapeutic strategy of exocrine adenocarcinoma of the pancreas].

The prognosis of pancreatic adenocarcinoma remains poor, with a 5-year survival rate lower than 5%. Resection, the gold standard treatment, can be performed in less than 10% of patients. Following surgery, the median survival is 12 months for the most favorable patients. Concomitant chemoradiation, as an adjuvant treatment is superior to surgery alone, in terms of survival, controlled trials are currently performed. Neoadjuvant chemoradiation is a new approach, potentially able to increase survival and resection rate. This work justifies the role of these schemes, in terms of modalities and potential advantages.

Adenocarcinoma↗
PubMed1997

[Hepatic resections in the treatment of hepatocellular carcinoma].

Treatment of hepatocellular carcinoma has become multidisciplinary. Liver resection, when technically feasible, remains the procedure of choice for non cirrhotic patients. On the contrary, its indications are decreasing for cirrhotics with the emergence of interventional therapies and since selected patients with small tumors and sufficient life-expectancy have become candidates to liver transplantation. Better results have to be obtained by adjuvant therapies in order to decrease the propension of the hepatocellular carcinoma to recur inside the liver. Intraarterial injection of lipiodol iodine-131 seems to give encouraging results in reducing the local recurrence rate after liver resection.

Carcinoma, Hepatocellular↗
PubMed1996

High-grade dysplasia in an adenoma of the upper esophagus developing on heterotopic gastric mucosa.

Patches of hererotopic gastric mucosa located in the upper esophagus are a frequent finding at endoscopy. These lesions are thought to be of congenital origin and of low malignant potential. However, several cases of adenocarcinoma developing on inlet patches have recently been described. We report here a new case of adenoma that had developed on heterotopic gastric mucosa in the upper esophagus, associated with an area of high-grade dysplasia. This polyp was removed surgically under endoscopic guidance, after confirmation of the superficial pattern of the lesion by endoscopic ultrasonography. This report emphasizes the malignant potential of esophageal inlet patches of heterotopic gastric mucosa.

Adenoma, Villous↗
PubMed1996

[Long-term results of vertical banded gastroplasty for morbid obesity].

UNLABELLED: Morbid obesity, defined by Body Mass Index (BMI) > 40 kg/m2, has an adverse effect on longevity due to a variety of illnesses. Among the numerous techniques proposed to control morbid obesity, Vertical Banded Gastroplasty (VBG) changes eating behavior. The aim of this study was to analyse the long term results of VBG. MATERIAL AND METHODS: Between October 1987 and July 1993, 62 patients, 7 men and 55 women, from 20 to 68 years old (Mean: 37.4 +/- 9 ans), underwent VBG for morbid obesity. Preoperative mean weight and BMI were 123 +/- 27 kg and 47.3 +/- 9.8 kg/m2 respectively. Associated diseases were diabetes mellitus (n = 31), hypertension (N = 29), hypercholesterolemia (N = 10), hypertriglyceridemia (N = 21) and joint diseases (N = 18). RESULTS: VBG was performed with a 50 mm marlex mesh in 20 cases and with a 47 to 50 mm silastic ring in 42 cases. On patient died 3 years later from alcoholic liver cirrhosis and 4 were lost to follow-up. With a mean follow-up of 31 months, mean weight and BMI were 86 +/- 21 kg (p < 0.001) and 32.1 +/- 9.8 kg/m2 (p < 0.001) respectively. Removal of the ring was performed in 3 cases, 1 because of neurologic complications and 2 at the patient's request. Eight patients (13%) failed to achieve satisfactory weight loss. Diabetes mellitus and hypertension resolved in 19 cases, hypercholesterolemia resolved in 7 cases and hypertriglyceridemia resolved in 11. CONCLUSION: VBG provides significant weight loss which reduces the frequency of medical disorders associated with obesity. This result was achieved in 87% of patients. The surgical procedure for morbid obesity must be decided conjointly with endocrinologist, psychiatrist and surgical staff for good long-term results.

Adult↗
PubMed1996

[Preservation of the pylorus in duodenopancreatectomy].

The authors present an overview of the technique of pancreatoduodenectomy with pylorus preservation. The main technical variants since the original description by Traverso and Longmire in 1978 are described. Advantages and drawbacks of the technique from a carcinologic and functional point of view are presented and discussed. Pancreatoduodenectomy with pylorus preservation appears to be the procedure of choice in most cases. However, it should be avoided in a few patients with invasion of the proximal duodenum by a periampullary carcinoma for whom a curative resection requires the addition of a gastrectomy.

Anastomosis, Surgical↗
PubMed1996

[Pancreatectomy for intraductal papillary mucinous tumor of the pancreas].

Twelve cases of pancreatectomy for intraductal papillary-mucinous tumor of the pancreas operated between August 1985 and February 1996 are reported. Mean age of the patients was 57.6 years (range: 25 to 77 years). Two of them were female and 10 were male. Ten patients underwent a pylorus preserving pancreaticoduodenectomy, one patient a segmental isthmic pancreatectomy and one other a left pancreatectomy. Histologic examination of the operative specimen showed benign ademomatosis with severe dysplasia in 3 cases, intramucosal or microinvasive carcinoma in 7 cases and invasive carcinoma in 2 cases. Two patients died during the period of follow-up, one at 20 months from metastases, the other one at 33 months accidentally. The 10 remaining patients were alive and disease-free with a follow-up of 3 to 93 months (mean time of follow-up: 38 months). Pancreatectomy is indicated without delay as soon as the diagnosis of this uncommon tumor is obtained.

Adenocarcinoma, Mucinous↗
PubMed1995

Prospective study of prognostic factors in patients with unresected hepatic metastases from colorectal cancer. Fondation Française de Cancérologie Digestive.

Prognostic factors of unresected liver metastases in patients with colorectal cancer are not well established. A total of 544 patients with unresected liver metastases from colorectal cancer were registered in a national survey over a 1-year period and followed until death. Twenty factors were studied in a univariate analysis (log rank test) and 16 influenced survival (P < 0.01). These 16 factors were entered in a multivariate analysis (Cox model) and eight, ranging from the most significant (relative risk of death 1.9) to the less significant (relative risk of death 1.2), independently influenced survival: performance status, alkaline phosphatase level, number of involved liver segments, administration of chemotherapy, presence of extrahepatic metastases, site of the primary tumour, prothrombin time and resection of the primary lesion. Two simple classifications are proposed, taking into account the performance status and the alkaline phosphatase level, or the performance status and the number of involved liver segments.

Aged↗
PubMed1995

[Identification of human carcinogenic risks in IARC monographs].

For more than twenty years, the IARC has been evaluating the carcinogenic risk to humans of chemicals, groups of chemicals, complex mixtures, occupational exposures, behavioral and life-style exposures, biological agents, such as bacteria and viruses, and physical agents, such as radiation, on the basis of published studies of carcinogenicity in humans and laboratory animals. This paper includes the list established by IARC of substances carcinogenic to humans.

Animals↗
PubMed1995

[Upper digestive duplications in adults].

Congenital gastrointestinal duplications are uncommonly diagnosed in adult patients, and generally present as a cystic or occasionally tubular malformation. The duplication is composed of a smooth muscle wall continuous with the muscle layer of the intestinal wall and an inner mucosal lining. From December 1988 to May 1994, five patients were operated for gastrointestinal tract duplications [esophageal (1), gastric (2), duodenal (2)]. Duplications were symptomatic in three patients, and discovered incidentally in the other two. The diagnosis was established by ultrasonography (3 patients) and computed tomography (one patient). One female presented an adenocarcinoma arising in an esophageal duplication and died one year after surgical resection. Because of potential malignant transformation, these malformations must be resected. Preoperative diagnosis is important for conservative resection, except in the presence of malignancy when resection must be curative.

Adenocarcinoma↗