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Biomedical subjects

C Partensky

Publications and source records attributed to C Partensky.

At least 91 records · Page 5Linked to original sources
PubMed1988

Amplification of epidermal growth factor receptor gene but no evidence of ras mutations in primary human esophageal cancers.

Primary esophageal squamous cell carcinomas from 41 patients were analyzed for the presence of proto-oncogene alterations associated with this malignancy. The occurrence of activating ras gene mutations in 25 tumors was determined using oligomer hybridization of target sequences amplified by polymerase chain reaction. We found no evidence for mutations in codons 12 and 61 of the H-ras, K-ras, and N-ras genes, nor in codon 13 of the K-ras and N-ras loci in any of these tumors. The apparent absence of activated ras oncogene in esophageal cancers represents a possible exception to the presence of these mutations found consistently in numerous other types of human malignancies, and is in striking contrast to the 40% prevalence of ras mutations in human colorectal cancers. Southern blot hybridization experiments with DNAs from tumors demonstrated amplification of the epidermal growth factor receptor gene (c-erbB) in two of 25 carcinomas. No amplification of the structurally related c-erbB2 (neu) gene was detected. In three out of 12 carcinomas, the level of epidermal growth factor receptor RNA was significantly higher than in normal esophageal mucosal tissue. Our results suggest that enhanced transcription of the epidermal growth factor receptor gene is associated with the development of some esophageal cancers.

DNA, Neoplasm↗
PubMed1987

Clinical and hormonal effects of a long-acting somatostatin analogue in pancreatic endocrine tumors and in carcinoid syndrome.

Nine patients with pancreatic apudomas (seven gastrinomas, one glucagonoma, one tumor secreting a substance P-like component) and nine with metastasized carcinoid tumors were treated with a somatostatin analogue (SMS 201-995), administered subcutaneously twice daily for 3 days. Treatment was pursued for 2 to 12 months in nine patients in whom SMS was clinically and/or biologically beneficial. In gastrinomas, SMS decreased plasma gastrin in all but one patient, inhibited the residual gastric acid secretion under H2-blockers and improved diarrhea; in the glucagonoma patient, glucagonemia decreased and skin lesions disappeared. In carcinoid syndrome, clinical efficacy was partial and inconstant; daily 5-hydroxyindole acetic acid (5-HIAA) output was slightly decreased. Plasma substance P levels decreased in six patients with initially high concentrations. No antitumoral activity or side effects have been so far evidenced. SMS 201-995 is a useful, well-tolerated agent in secreting pancreatic apudomas and to a lesser extent in carcinoid syndrome, where high-dosage regimens may be required.

Adult↗
PubMed1987

Comparison of regulations on occupational carcinogens in several industrialized countries.

Regulations controlling the manufacture and use of carcinogens in the industrial setting of various countries are examined. In addition, the occupational exposure limits (OEL) of chemicals known or suspected to be carcinogenic in humans are listed, and criteria for the establishment of OELs are discussed. It is also stressed that control measures should not be confined to a few developed countries, and it is hoped that attracting attention to their unevenness will contribute to the implementation of a more efficient primary prevention of cancer.

Carcinogens↗
PubMed1987

Obstructive jaundice by a dissecting aneurysm of celiac axis and hepatic artery.

We report a case of dissecting aneurysm of the celiac axis and hepatic artery resulting in obstructive jaundice. The aneurysm was demonstrated both by ultrasound and by angiography, but the associated aortic dissection was apparent only on CT scan. The patient was treated with percutaneous transhepatic biliary drainage, surgical exclusion of the aneurysm by ligation, and progressive dearterialization of the hepatic artery.

Aortic Dissection↗
PubMed1987

Cystic malformations of the cystic duct.

While cystic malformations of the main biliary tract are wellknown and classified, it is exceptional to find cystic malformations of the accessory biliary tract (cystic duct). An adolescent aged 15 years and an adult of 49 years were operated for cysts of the cystic duct revealed by associated lesions, a cyst of the common bile-duct and gallbladder stones respectively. Ultrasonography showed cystic lesions which opacification during intravenous cholangiography and endoscopic retrograde cholangiography (EPRC) proved to be related to the cystic duct. The radiography outline of the biliary pathways so obtained served as a guide to the operative procedure, consisting of excision of the accessory biliary tract in both cases combined with resection of the common bile-duct cyst in one case. The radiologic, anatomic and histologic findings distinguished the lesions encountered from other malformations of the accessory biliary tract and confirmed their derivation from the cystic duct.

Adolescent↗
PubMed1987

[Treatment of hepatic polycystosis by intracystic injection of alcohol].

Two patients with symptomatic polycystic liver disease were treated with aspiration and injection of alcohol into the cyst cavities. Only the cysts larger than three to five centimeters were treated. No complications were encountered. Transient pain was observed in one case. There was no recurrence of the treated cysts on follow-up examinations at five to 74 months. These results suggest that aspiration and injection of alcohol is an effective treatment for symptomatic polycystic liver disease.

Cysts↗
PubMed1986

Response of experimental animals to human carcinogens: an analysis based upon the IARC Monographs programme.

Only the results of epidemiological studies can be used to establish a causal relationship between an exposure to an agent and human cancer; however, such studies often cannot be carried out due to limitations of population or latent period or to the presence of mixed exposures. It is essential, therefore, that the validity be established of extrapolating to humans the results obtained from long-term carcinogenicity tests in animals. The responses of experimental animals to known and suspected human carcinogens, as evaluated in the IARC Monographs series, were analysed as an indication of the sensitivity of animal tests for predicting human carcinogens. Although the response was high - 84% - it would have been even higher had all the compounds been adequately tested experimentally. An additional finding was that for many exposures causally related to human cancer, there is a target organ in common between humans and at least one animal species, despite many inherent physiological differences. These findings show clearly the importance of experimental carcinogenicity studies in the primary prevention of cancer.

Animals↗
PubMed1986

[A triple association: rectocolonic adenomatosis, gastroduodenal polyposis and secreting adrenocortical adenoma].

A case of adenomatosis coli, gastroduodenal polyps, and functional adrenocortical adenoma in a 28 year-old woman is reported. The association of cystic fundic gland polyposis and duodenal adenomatosis was demonstrated endoscopically. The particular point of interest in this case report is the functional nature of the adrenocortical adenoma. Endocrine tumors associated with adenomatosis coli are generally discovered at autopsy. No similar case has been previously published.

Adenoma↗
PubMed1985

Ultrasonic features of aneurysms of splanchnic arteries.

A review of nine patients with aneurysms of the splanchnic arteries was undertaken. The records and the sonographic findings were analysed. Seven of the nine aneurysms could be diagnosed ultrasonographically. The aneurysm appeared as a round hypoechogenic nodule connected to or in close relation with the feeding artery. In four patients the lesions were incidentally detected and two of them were operated upon because of a risk of spontaneous rupture.

Adult↗