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Biomedical subjects

C Pelfini

Publications and source records attributed to C Pelfini.

At least 19 recordsLinked to original sources
PubMed1989

[Flurbiprofen in gel: study of acceptability, tolerability and evaluation of its allergenic potential].

The study aimed to assess the allergenic capacity of gel-based flurbiprofen in healthy volunteers, and then evaluate its acceptance and tolerability in patients affected by various skin diseases. Twenty-five healthy volunteers of both sexes (age range: 19-35 years) were included in the first phase of the study. Allergenic capacity was evaluated using Kligman's maximization test in which 5 patch tests were carried out on the same site using a solution of 2.5% lauryl sulphate, followed by patch tests using gel-based flurbiprofen. Control tests were performed 15 days later. The second phase of the study comprised 15 hospitalised patients, with an age range of between 18 and 70 years, affected by psoriasis and eczema. All patients were treated with gel-based 5% flurbiprofen twice daily for 2 weeks. Patients were asked to fill in a questionnaire in order to assess the acceptance and tolerability of the drug. Only one subject in the first group showed an allergic response to the drug. Adverse effects were observed in two patients in the second group. Drug acceptance was excellent.

Adult↗
PubMed1979

Insulin receptors in psoriasis.

We have demonstrated how in psoriasis, irrespective of any diabetic family history, there exists a state of hyperinsulinism with a decreased resistance to insulin, which is aggravated by obesity. Since reviewing the latest studies concerning diabetes at the receptor level, we have carried out a comparative study dealing with insulin receptors in lymphocytes in homogeneous groups of normal, obese, and psoriatics of normal weight and overweight. We have also made a comparison regarding the behaviour of the receptors in these various metabolic states.

Blood Glucose↗
PubMed1979

Insulinogenic indexes in psoriasis.

We have earlier demonstrated that in psoriasis there exists a reduced tolerance to carbohydrates in association with hyperinsulinism. To pursue this problem further, we felt it worthwhile to deal with the results of the oral glucose tolerance test performed on 78 subjects (divided into homogenous groups of normal, obese and psoriatic groups, both with and without diabetic genetic history and obesity) with determinations of both blood glucose and blood insulin levels. We have calculated the insulinogenic indexes by using the techniques elaborated by various authors (I/G, delta I/delta G, AI/AG) and we have then carried out a statistical evaluation both of these indexes and of the ratio between the various indexes employing not only the usual techniques but also that of correlation and simple and multiple regression. We have done this in order to evaluate which of these indexes is better suited to demonstrate the physiopathological mechanism concerning the relationship between insulin hypersecretion and reduced carbohydrate tolerance in the various pathological conditions which we have dealt with.

Blood Glucose↗
PubMed1977

Psoriasis and insulin secretion. Preliminary results.

We have studied psoriatic subjects with normal weight and with overweight without inherited diabetic familiarity. The results seem to indicate the existence in psoriasis of an endogenous insulin-resistence. In this prospective the hypothesis that psoriasis carries a diabetogen risk is suggested.

Blood Glucose↗