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Biomedical subjects

C Pemberton

Publications and source records attributed to C Pemberton.

9 recordsLinked to original sources
PubMed1999

The amino terminal regions of proBNP and proANP oligomerise through leucine zipper-like coiled-coil motifs.

We provide the first report of unique leucine zipper-like coiled-coil sequence motifs at the amino terminus (N-) of proBrain Natriuretic Peptide (proBNP) and proAtrial Natriuretic Peptide (proANP). These motifs were highly conserved across most of the known natriuretic peptide sequences from different species. Consistent with computer based modelling predictions, size exclusion (SE) chromatography analysis confirmed human and ovine N-BNP, N-ANP and human proBNP in plasma extracts to elute as high molecular weight oligomers. Synthetic model peptides corresponding to the proposed leucine zipper-like coiled-coil regions of proBNP, proANP and their related N-terminal peptides were shown to be sufficient to induce oligomerisation when assessed on size exclusion HPLC. To our knowledge, this is the first report of circulating peptides that oligomerise through leucine zipper-like coiled-coil motifs, and adds a new dimension to the field of vasoactive peptide research.

Amino Acid Sequence↗
PubMed1998

Have women's voices lowered across time? A cross sectional study of Australian women's voices.

Various aspects of our communication are well known to have changed over time (1-3). This article describes a cross-sectional study that examined the acoustic characteristics of two groups of Australian women aged 18-25 years from recordings made in 1945 and 1993 and investigated the possible changes in the voice across generations. Archival recordings from 1945 which had been used in a longitudinal study (4) were compared to recordings made in 1993. The results of this study show that women in 1993 have significantly deeper voices than women of the same age recorded in 1945. The possible factors influencing this change are discussed.

Adolescent↗
PubMed1995

Speaking fundamental frequency changes over time in women: a longitudinal study.

Archival recordings of the human voice are a relatively untapped resource for both longitudinal and cross-sectional research into the aging voice. Through the availability of collections of old sound recordings, speech pathologists and voice scientists have access to a wealth of data for research purposes. This article reports on the use of such archival data to examine the changes in speaking fundamental frequency (SFF) in a group of Australian women's voices over the past 50 years, and discusses the benefits and problems associated with using archival data. Recordings made in 1945 of women were compared with recordings of the same women made in 1993 to investigate the changes in SFF with age. The results demonstrate a significant lowering of SFF with age in this group of Australian women. The implications for the interpretation of cross-sectional data on the aging voice, the use of archival data in voice research, and the need for further research using archival data are discussed.

Adolescent↗
PubMed1993

Characteristics of normal larynges under flexible fiberscopic and stroboscopic examination: an Australian perspective.

The purpose of this study was to investigate the structure and function of larynges of 35 subjects with normal voices. Volunteers aged between 20 and 50 years with no history of voice disorders or laryngeal surgery, no current allergies, no formal voice training, and no hyperactive gag reflex were required to perform various vocal manoeuvres that were carried out under continuous and stroboscopic light. An assessment form was devised to record the condition and function of the larynx. The videotapes of the procedure were rated by experienced judges. The Australian Fiberscopic Profile was devised to record the relevant parameters under continuous light. Videostroboscopic ratings were carried out using the Bless protocol rating. High interjudge agreement was found across the two rating profiles.

Adolescent↗
PubMed1993

Ilizarov fixation.

Professor Gavanit Ilizarov, a Russian, was practising medicine in Siberia and although not trained as a surgeon he was becoming increasingly faced with orthopaedic problems. As he had no means of treating many of these, he devised his own system based on Kurstner wires and rings but using bicycle spokes and modified clutch rings. This was in 1951. He continued to make modifications over the years and, as the system has been introduced to the rest of the world, others, too, have added their own adaptations. There are now 42 components which go to make up the Ilizarov system. By using various combinations of these components it is possible to build a frame to treat a variety of orthopaedic problems i.e. deformities, non-unions and limb lengthening.

Bone Lengthening↗
PubMedDate not supplied

Diagnosing and treating bone metastases.

There can be little that is more distressing for a nurse to witness than the anguish and despair of patients and their relatives caused by unrelieved pain. In spite of increasing doses of morphine, some patients remain in pain. Why is this and, as nurses, what can we do about it? It is the nurse who spends time with the patients and relatives, both at home and in hospital. We are, therefore, in the front line, supporting patients and assessing their needs.

Anti-Inflammatory Agents, Non-Steroidal↗