Biomedical subjects

C Penton

Publications and source records attributed to C Penton.

3 recordsLinked to original sources

PubMed1999

Prevention of common mental health problems among adolescents. National and local best practices in school-based health centers.

A primary goal of school-based health centers is to reduce the occurrence of high-risk behaviors and mental health problems commonly exhibited by adolescents. This paper provides a review of national best practice prevention strategies for common adolescent problems including school dropout, violence, and other high-risk behaviors. Specific prevention programs, currently in use in Louisiana school-based health centers, are described and linked to national best practice.

Adolescent↗

PubMed1986

Subcutaneous implantation of a ferrocene-mediated glucose sensor in pigs.

Miniature, amperometric glucose sensors were constructed using entrapped 1,1'-dimethylferrocene to mediate electron transfer between immobilised glucose oxidase and a carbon base electrode. Electrodes were calibrated in buffered glucose solutions and then implanted in the subcutaneous tissue of anaesthetised, non-diabetic pigs. Subcutaneous tissue glucose concentrations, as measured by the sensor, were about 20% of blood glucose values, measured by a conventional glucose oxidase assay. After an intravenous 0.07 mol bolus glucose injection, electrode responses increased with almost no time lag, but the subsequent rates of rise and fall of electrode-measured tissue glucose concentrations were slower than that of the blood values. After an intravenous 0.2 U/Kg bolus short-acting insulin injection the electrode response was also rapid, but decreased at a slower rate than the blood glucose concentrations. We conclude that this is a feasible technology for future development as an implantable glucose sensor for use in diabetic man.

Animals↗

PubMed1986

Potentially-implantable, ferrocene-mediated glucose sensor.

We describe the construction and in vitro testing of a new potentially-implantable amperometric glucose sensor which is based on mediated electron transfer between immobilized glucose oxidase and a graphite base electrode. Under potentiostatic control, entrapped 1,1'-dimethylferrocene acts as an alternative electron acceptor to oxygen and provides a sensing strategy which is relatively unaffected by possible fluctuations in in vivo oxygen tension. Simple 1 mm wide electrodes with a polyurethane membrane gave linear current responses to at least 20 mmol/l glucose with a mean response time of 68 s. An acceptable proportion (17%) of electrodes had low or zero drift over 17 h at 37 degrees C. With plasma samples from diabetic and non-diabetic subjects, glucose concentrations measured by the sensor were significantly correlated with values obtained by a reference laboratory glucose analyser but were proportionally lower. Extension of this study to in vivo testing and further miniaturization of electrodes is justified.

Blood Glucose↗