PubMed Health⌕ Search

Biomedical subjects

C Perry

Publications and source records attributed to C Perry.

At least 55 records · Page 3Linked to original sources
PubMed1980

Seminoma in childhood.

We report on an 8-year-old boy who had a seminoma 2 years after orchipexy of the left testis. Seminoma is a rare tumor in childhood and, to our knowledge, this is the youngest patient with seminoma to be reported in the literature.

Child↗
PubMed1978

Dextromethorphan: radioimmunoassay and pharmacokinetics in the dog.

A specific radioimmunoassay (RIA) for the determination of the widely used non-narcotic antitussive agent, dextromethorphan (DM) in plasma and urine has been developed using an antiserum to DM which was obtained from rabbits following immunization with an albumin conjugate of (+)-3-methoxymorphinan-17-succinyloxyethyl. Specificity of the RIA was achieved by selective extraction of DM from its known metabolites into hexane at pH 6.5 with 86% recovery. Employing tritium labelled-DM as the radioligand the RIA had a limit of sensitivity of about 4 ng/ml of plasma using a 0.5 ml sample. Following I.V. administration of 2 mg/kg of DM to two dogs, the plasma levels of intact DM declined biexponentially; the terminal exponential phase having a half-life of 2.5-3.9 hr. The volume of distribution of the central compartment ranged from 5-6.4 l/kg while the metabolic clearance rate ranged from 2.5-2.6 1/hr/kg. Oral administration of 10 mg/kg of DM in gelatin capsule resulted in peak plasma levels of 50 and 92 ng/ml at 2 hr post-drug. Following both routes of administration, less than 3.5% of the dose was excreted in the urine as intact DM indicating almost complete biotransformation and/or alternate routes of excretion. In one human subject who received 0.5 mg/kg of DM P.O. in a syrup, the plasma levels were less than 1 ng/ml.

Animals↗
PubMed1978

Can alternative schools succeed where Benjamin Spock, Spiro Agnew, and B. F. Skinner have failed?

This study sought to determine whether student behavior was as great a problem in a sample of 18 California alternative high schools. As a result of on-site observations and interviews with students and teachers, the authors concluded that discipline rarely was a major concern in the alternative schools. General agreement existed among both students and teachers. Fourteen possible reasons to account for the basic finding were hypothesized. The reasons included small school size, flexible schedules, frequent informal interaction between students and teachers, and fewer rules.

Achievement↗
PubMed1977

Plasma lipoprotein distributions in male and female runners.

Recent studies have shown a consistent association between relatively low plasma concentrations of high-density lipoprotein (HDL) cholesterol and increased risk of coronary heart disease. A cross-sectional comparison was made of the distribution of plasma lipids and lipoproteins in groups of 41 male and 43 female long distance runners versus larger control groups matched for age and sex, randomly selected from northern California towns. The runners showed modestly lower total cholesterol concentrations, while their triglyceride levels were only 50% of control. HDL-cholesterol was higher in runners than controls (75 +/- 14 vs 56 +/- 14 mg/100 ml for women; 64 +/- 13 vs 43 +/- 10 for men), while low-density lipoprotein cholesterol was lower (113 +/- 33 vs 124 +/- 34 for women; 125 +/- 21 vs 139 +/- 32 for men). All differences were statistically significant (p less than 0.05), and only partially attributable to known factors other than high physical activity level. Since the runners were predominantly normotensive, relatively lean, and exclusively nonsmokers, they appear to constitute a remarkably favored group with respect to risk of cardiovascular disease.

Adult↗