The right of public access to cadaver organs.
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Biomedical subjects
Publications and source records attributed to C Perry.
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We report on an 8-year-old boy who had a seminoma 2 years after orchipexy of the left testis. Seminoma is a rare tumor in childhood and, to our knowledge, this is the youngest patient with seminoma to be reported in the literature.
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A longitudinal pilot study gathered data on the onset and prevention of smoking, alcohol, and drug abuse among 526 students from two junior-high-schools in California. Over two school years, students who were trained to resist social pressures toward tobacco, alcohol, and drug use began smoking at less than one-half the rate of those who did not receive special training. Frequent alcohol and marijuana use was also less prevalent among the students who received such training.
Tenth grade health classes in three high schools received a special program focusing on the immediate physiological effects of cigarette smoking and the social cues influencing adoption of the smoking habit, and classes in two control schools received standard information on the long-term effects of smoking. Only subjects in the special program reported a decrease in smoking from pre to post-test; they also scored higher than controls on a knowledge test. Carbon monoxide levels were significantly lower for subjects in the special group at post-test.
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A specific radioimmunoassay (RIA) for the determination of the widely used non-narcotic antitussive agent, dextromethorphan (DM) in plasma and urine has been developed using an antiserum to DM which was obtained from rabbits following immunization with an albumin conjugate of (+)-3-methoxymorphinan-17-succinyloxyethyl. Specificity of the RIA was achieved by selective extraction of DM from its known metabolites into hexane at pH 6.5 with 86% recovery. Employing tritium labelled-DM as the radioligand the RIA had a limit of sensitivity of about 4 ng/ml of plasma using a 0.5 ml sample. Following I.V. administration of 2 mg/kg of DM to two dogs, the plasma levels of intact DM declined biexponentially; the terminal exponential phase having a half-life of 2.5-3.9 hr. The volume of distribution of the central compartment ranged from 5-6.4 l/kg while the metabolic clearance rate ranged from 2.5-2.6 1/hr/kg. Oral administration of 10 mg/kg of DM in gelatin capsule resulted in peak plasma levels of 50 and 92 ng/ml at 2 hr post-drug. Following both routes of administration, less than 3.5% of the dose was excreted in the urine as intact DM indicating almost complete biotransformation and/or alternate routes of excretion. In one human subject who received 0.5 mg/kg of DM P.O. in a syrup, the plasma levels were less than 1 ng/ml.
This study sought to determine whether student behavior was as great a problem in a sample of 18 California alternative high schools. As a result of on-site observations and interviews with students and teachers, the authors concluded that discipline rarely was a major concern in the alternative schools. General agreement existed among both students and teachers. Fourteen possible reasons to account for the basic finding were hypothesized. The reasons included small school size, flexible schedules, frequent informal interaction between students and teachers, and fewer rules.
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