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Biomedical subjects

C Petersson

Publications and source records attributed to C Petersson.

53 records · Page 3Linked to original sources
PubMed1994

Karyotypic changes in phyllodes tumors of the breast.

Cytogenetic analysis of short-term cultures of five phyllodes tumors of the breast-classified as benign (one tumor), borderline malignant (two tumors removed from the same breast in 1991 and 1993), and malignant (two tumors)--revealed clonal changes with simple structural abnormalities in the benign tumor, the borderline malignant tumors, and one malignant tumor in which benign areas and areas of borderline malignancy were also present. In contrast, the malignant tumor without admixed borderline malignant or benign areas had a complex karyotype. The karyotype of the benign phyllodes tumor was 46,XX,del(12)(p11p12)/46,XX,t(8;18)(p11;p11)/46,XX. The first borderline malignant phyllodes tumor had t(3;20)(p21;q13) as the sole abnormality. When the tumor recurred, this was no longer the only clone detected and the tumor karyotype was now 46,XX,t(3;20)(p21;q13)/46,XX,t(9;10)(p22;q22)/46,XX,t(1;8) (p34;q24)/46,XX,del(11)(q22-23)/46,XX. The malignant/borderline malignant/benign tumor had t(1;6)(p34;p22) as the sole clonal abnormality. Finally, the karyotype of the malignant phyllodes tumor which contained no benign or borderline malignant areas was 42,XX,der(1)t(1;4)(q21;q21),der(3)t(3;17)(q29;q21), -4,i(8)(q10), -10, -13,i(13)(q10),der(14)t(1;14)(q21;p11),der(14)t(4;14) (p12;p11), -17/80-90,idemx2, +del(1)(q12), +i(1)(p10), +dic(5;5)(p14;p14), +i(6)(p10), +del(7)(p11), +dup(7)(q11q36), +i(15)(q10),inc/46,XX. The findings indicate some cytogenetic similarities between benign/borderline malignant phyllodes tumors and fibroadenomas of the breast, presumably reflecting similar pathogenetic mechanisms in the two types of mixed-lineage tumors.

Aged↗
PubMed1994

Suppressed antibody and interleukin-6 responses to acute pyelonephritis in pregnancy.

This study examined the effect of pregnancy on the host response to acute pyelonephritis. Urine and serum samples were obtained at the time of diagnosis and after two weeks, from non-pregnant and pregnant women with acute pyelonephritis. The samples were analyzed for interleukin-6 (IL-6) and specific antibody activity to antigens extracted from the Escherichia coli strain infecting each patient. The host response to infection was further quantitated as fever, C-reactive protein, and renal concentrating capacity. Acute pyelonephritis in non-pregnant and pregnant women was accompanied by a significant serum and urine antibody response. The serum antibody response was significantly lower in the pregnant group. The IL-6 levels in serum and urine at diagnosis were significantly higher in the non-pregnant compared to the pregnant women. These results demonstrate that the immunosuppression of pregnancy includes the mucosal IL-6 and specific antibody responses to acute pyelonephritis caused by E. coli.

Acute Disease↗
PubMed1994

The incidence of fractures of the clavicle.

The age- and gender-specific incidences were calculated in 2035 cases of fracture of the clavicle. The fractures were classified in three groups according to the Allman system. Each group was further divided into undisplaced and displaced fracture subgroups, with an extra subgroup of comminuted midclavicular fractures in Group I. Seventy-six percent of the fractures were classified as Allman Group I. The median age in this group was 13 years. There were significant differences in age- and gender-specific incidence between the undisplaced, displaced, and comminuted fracture subgroups. Twenty-one percent were classified as Allman Group II. The median age of the patients was 47 years, and there was no difference in age between the undisplaced and displaced fracture subgroups. Three percent were classified as Allman Group III, and the median age of the patients in this group was 59 years. All three groups were characterized by a significant preponderance of men, and there was a significant increase in the incidence of clavicular fracture, both overall and sports-related, between 1952 and 1987.

Adolescent↗
PubMed1993

Superantigen-based tumor therapy: in vivo activation of cytotoxic T cells.

We have recently demonstrated that the superantigen staphylococcal enterotoxin A (SEA) targets in vitro activated cytotoxic T lymphocytes against tumor cells expressing major histocompatibility complex (MHC) class II antigens. In this report we analyze the use of SEA as an immunoactivator in vivo. Treatment of mice with SEA activated a fraction of CD3+ T cells apparently as a function of their T cell receptor V beta expression. SEA induced interleukin-2 receptor expression and proliferation in both CD4+ and CD8+ T cells. This proliferative response was dose-dependent (0.1-100 micrograms/mouse), peaked during day 1 after treatment and declined to background levels within 4 days. The cytotoxic response, measured as cytotoxicity to SEA-coated MHC class II+ target cells (staphylococcal-enterotoxin-dependent cell-mediated cytotoxicity, SDCC), was maximal at a dosage of 1 microgram SEA/mouse. The SDCC was confined to the CD8+ T cell compartment, peaked 2 days after treatment and declined to background levels within 4 days. A second injection of SEA on day 5 after the first SEA treatment resulted in SDCC function with kinetics and magnitude identical to that seen after one injection. These results pave the way for the use of SEA in the treatment of MHC class II+ tumors.

Animals↗
PubMed1993

The natural course of lateral clavicle fracture. 15 (11-21) year follow-up of 110 cases.

110 patients with non-operated on fracture of the lateral end of the clavicle were reviewed on an average 15 years after the injury. There were 73 undislocated Neer Type I fractures, 23 dislocated Type II fractures and 14 intraarticular Type III fractures. The patients' age at trauma was 36 (2-71) years. At follow-up 95 shoulders were asymptomatic. 15 shoulders had moderate pain and dysfunction and were rated fair; no patient had severe, residual shoulder disability. There were 10 nonunions, 8 of these asymptomatic. We conclude that fracture of the lateral end of the clavicle does not require operation.

Adolescent↗
PubMed1992

Infectious diseases and day-care centre environment.

During the period from September 1986 to May 1987 all 25 day-care centre departments in the residential district of Teleborg in Växjö were studied to discover the frequency of absence due to infection. Mean absence/department was 6.6% (SD 2.2), with a range from 3.9% to 10.2%. During the period from September 1989 to May 1990 a follow-up study used the same methods to investigate 7 departments, which in the first study had shown the highest and lowest rates of absence due to infection. In addition, the carbon dioxide content in indoor air was measured in all departments in the district. The new measurements showed that the average absence due to infection in the 7 departments had fallen from 7.5% (SD 2.9) to 5.6% (SD 1.4). It was not possible to reproduce the division seen in the first study into departments with high and low absence rates. The variations in infectious morbidity observed could not be explained by differences between the departments as regards physical environment or working routines. By contrast, a considerable difference as regards carbon dioxide content in indoor air was seen between the 3 departments housed in converted dwellings and the 4 departments in purpose-built day-care centres; the mean values were 822 ppm and 458 ppm, respectively (Mann-Whitney U-test; p = 0.028).

Air Pollution, Indoor↗
PubMed1992

Fracture of the body, neck, or spine of the scapula. A long-term follow-up study.

Fractures of the scapula are often considered benign lesions with a favorable outcome. The aim of the current study was to analyze the long-term results after fracture of the muscle-covered parts of the scapula: its body, neck, and spine. Sixty-eight patients were available for clinical examination 14 years after they had sustained a fracture of the scapula. The fractures had been treated with immobilization and early active motion. The follow-up rating was based on patient satisfaction and shoulder motion. Fifty-one patients were rated good, 15 were rated fair, and two were rated poor. Forty-eight shoulders were roentgenographically reexamined. Fourteen had a moderate and six had a pronounced deformity of the scapula. Scapula deformity was associated with pain in eight of the shoulders. The results of the current study suggest that the long-term course after fracture of the scapula is not uniformly favorable. Fifty percent of the patients with residual scapula deformity have shoulder symptoms. In most cases, however, the shoulder disablement is slight or moderate.

Adolescent↗
PubMed1992

Drug consumption during the first 18 months of life of infants from smoking and non-smoking families.

In a geographically well defined population in southern Sweden, a study was made of the overall consumption of drugs by infants during their first 18 months of life. The study population comprised 240 infants, of whom 90 were from families where tobacco was smoked by one or both parents and 150 were from non-smoking families. The investigation was carried out retrospectively by interviewing the mothers at the routine 18-month check up at the child health clinic, combined with study of the medical records at the district health centre, and at the paediatric and ear, nose and throat departments of the nearby hospital. In addition, the reliability of the interview method compared with review of medical records was investigated. Particular attention was paid to the consumption of antibiotics and the relationship between 'passive smoking' and consumption of antibiotics necessitated by respiratory tract infections. There was widespread use of both prescribed and non-prescription remedies. At the age of 18 months, about two thirds of all infants in the area had been prescribed an antibiotic (or other antibacterial agent) on at least one occasion. Infants from smoking families had been prescribed significantly more antibiotics than had infants from non-smoking families. The same pattern was also apparent for nose drops and dimethicone/dicyclomine hydrochloride. The incidence of respiratory tract infections requiring antibiotic treatment was higher in infants from smoking families than from non-smoking families in all the three-month age groups up to 15 months. The responses to the retrospective interview accorded closely with the details recorded in the medical records.(ABSTRACT TRUNCATED AT 250 WORDS)

Anti-Bacterial Agents↗
PubMed1990

A retrospective study of respiratory tract infections among children in different forms of day care.

This retrospective study investigated the records from July 1985 to June 1986 of all medical visits due to acute respiratory tract infections (RTIs) in infants aged 1-3 years. The study, in a municipal district, included all visits to the district health centre as well as visits to the paediatric and ear, nose and throat departments of the nearby hospital. The study population consisted on 489 children, of whom 140 were cared for in day-care centres (DCC), 146 in family day-care (FDC), while 203 did not receive any sort of municipally-supported day care (home care, HC). During the year studied, 223 children needed treatment by a doctor for acute RTI on altogether 499 occasions leading to the prescription of 325 courses of antibiotics. As regards RTIs as a whole and regarding those treated with antibiotics, the incidence density was greatest among the DCC children and lowest among the HC children, while the FDC children formed an intermediate group.

Anti-Bacterial Agents↗
PubMed1989

A prospective study of infectious morbidity and antibiotic consumption among children in different forms of municipal day-care.

During the 9-month period September 1986-May 1987, reasons for absence and antibiotic consumption were investigated among children cared for in day-care center(s) (DCC) and Swedish town. family day-care (FDC) within a limited geographical area of a medium-sized Swedish town. All 352 children in 11 DCC in this area and 199 children in FDC were included in this prospective study, which intended to elucidate the infectious morbidity. The investigation period comprised 55,760 and 26,019 expected days' attendance for the DCC and FDC children, respectively. A higher absence attributable to infection was evident at all ages in DCC children than in those in FDC. This difference tended to diminish with age. No difference in antibiotic consumption was evident between the 2 categories, and the diagnostic pattern was almost identical. In the DCC, overall absence figures, and absence due to infection, were considerably lower than in earlier comparable studies. Appreciable differences in absence due to infection and antibiotic consumption were also found between different "departments" in the DCC; both low and high-absence groups could be identified. There was an indication of differences between the groups both socially and in the environment at the DCC.

Anti-Bacterial Agents↗
PubMed1982

The effect of transistor-regulated direct current on non-fractured rabbit femur.

An experienced study was performed to examine the effects of transistor-regulated 20 microampère direct current on rabbit femur and to evaluate methods of measuring the effects. The anode and the cathode were both placed in drill holes in the anterior aspect of the cortex of the right femur, the left femur being used as a control with the electrodes without current. The effects of the electrical stimulation were evaluated by means of roentgenograms, photomorphometric measurements of the cortical width and measurements of bone volume, ash-weight and 85Sr uptake. In the roentgenograms it could be seen that osteogenesis was induced both at the anode and the cathode. Also, an increased uptake of 85Sr was demonstrated indicating an increased bone formation rate.

Animals↗
PubMed1980

Ectomography. A new radiographic method for reproducing a selected slice of varying thickness.

The mathematical basis is described of a new radiographic method by which an arbitrarily thick layer of the patient may be reconstructed. The reconstruction is performed from at least 60 images of the volume under examination. Each of these images, which have to be in digital form, is subjected to a special filtration process of its spatial frequencies. The combination of all the images will form the resulting image of the layer--the ectomogram. The method has been analysed and tested in experiments simulated with a computer.

Computers↗
PubMed1980

Target-effector cell interaction in the natural killer cell system. V. Energy requirements, membrane integrity, and the possible involvement of lysosomal enzymes.

Various inhibitors were used to study further the mechanism of natural killing and to compare it to lympholysis by cytotoxic T lymphocytes (CTL). The respiratory inhibitors DNP and NaN3 or low temperatures (0 degrees) blocked the cell contact phase of target-effector interaction in the CTL system but not the NK system. The lytic stage was also inhibited by the glycolytic inhibitors, iodoacetate and NaF, in the NK system as previously shown in the CTL system. Dimethylsulphoxide, a dipolar solvent, and cytochalasin B, a microtubule disruptor, inhibited NK target binding. Pre-treatment of Nk cells with glutaraldehyde, a protein cross-linking agent, completely prevented lysis, but not the formation of target-effector conjugates. The lytic phase of NK lysis was inhibited by chloroquine which also inhibited lysosomal enzyme function. Lysosome defective, beige mutant mice were also totally deficient in NK lytic function and this defect could not be restored with cGMP. T-cell and macrophage mediated cytolysis was previously shown to be relatively normal in beige mice. These results suggest that (i) the mechanism of NK cytolysis is a complex, multistep process, and (ii) this process is fundamentally different from that occurring in CTL. A 'stimulus-secretion' model of NK cytolysis is presented in which it is postulated that lysosomal enzymes may be the lytic molecules.

Animals↗
PubMedDate not supplied

Synoviorthesis in young patients with hemophilia and inhibitory antibodies.

In five patients under the age of 15 with hemophilia and inhibitors, due to frequent joint bleedings, 13 joints were treated with synoviorthesis (intra-articular injection of radioactive gold). The patients received high doses of factor VIII/IX for 2-4 days or were treated simultaneously with tolerance induction according to the Malmö protocol. Of the 13 joints treated, a bleeding-free interval of more than 6 months was obtained in nine of which six remained free from bleedings for more than a year. Ease of performance, the limited requirements of pre- and postoperative care, and a definite decrease in the joint bleeding frequency render synoviorthesis well suited for use in hemophiliacs with inhibitors who are otherwise difficult to treat.

Adolescent↗