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Biomedical subjects

C Pierard-Franchimont

Publications and source records attributed to C Pierard-Franchimont.

At least 19 recordsLinked to original sources
PubMed1991

Effect of topical corticosteroids on human sebum production assessed by two different methods.

Topical corticosteroids are widely used in cutaneous diseases. Although their mode of action on different skin compartments has been documented, little is known about their effects on the human sebaceous gland. We investigated the effects of two corticosteroids of differing potency on the excretion of sebum by means of two validated techniques: the Sebutape and the Lipometre. This study was conducted on the forehead skin of normal healthy subjects. The results obtained with both techniques correlated well. The application of both corticosteroids during a 4-week period led to a significant decrease in sebum excretion. This decrease was more pronounced with the more potent corticosteroid (Dermovate). In the light of these findings, it is likely that topical corticosteroids exert an anti-proliferative action upon the sebaceous cells in a similar manner to their effect in other skin compartments.

Administration, Cutaneous↗
PubMed1991

Dendrocytoclasis in Henoch-Schönlein purpura.

We studied by immunohistochemistry the fate of factor XIIIa-positive dermal dendrocytes in Henoch-Schönlein purpura. We have observed apoptosis affecting most of the perivascular dendrocytes. Such an aspect of dendrocytoclasis has never previously been reported in inflammatory disorders in the absence of vasculitis.

Child↗
PubMed1988

[Acute and chronic borreliosis transmitted by ticks in Europe].

Ticks are direct pathogenic agents, and also transmit some infectious diseases such as borreliosis. Clinical manifestations of borreliosis are multiple. They most often affect the skin, nervous system, joints and heart. Cutaneous pseudolymphomas, erythema chronicum migrans of Afzelius, acrodermatitis chronica atrophicans of Pick-Herxheimer, meningo-radiculitis and various arthropathies are the most commonly encountered diseases.

Acute Disease↗
PubMed1986

Massive lymphocyte-mediated apoptosis during the early stage of pseudopelade.

The early evolving lesions of the hair follicles are described in pseudopelade, a type of cicatricial alopecia where clues for the diagnosis of lupus erythematosus or lichen plano-pilaris are lacking. A sudden and synchronized cell death of all the cells of the epithelial sheaths of the hair follicles occurs and is associated with a dense infiltration by lymphocytes. The epidermis remains uninvolved. This unique aspect is most probably related to the mechanism of apoptosis. Its intensity and extension are much more pronounced than in lichen planus and in lupus erythematosus. Pathogenesis of at least some cicatricial alopecias could therefore be related to massive apoptosis without evident and close relationship with the classical etiologies, i.e. lichen planus and lupus erythematosus.

Alopecia↗
PubMed1985

Proliferation and hyperplasia of vascular endothelium in human skin.

In a number of diseases of the skin, proliferation of endothelial cells is altered. Replication of endothelial cells has been evaluated by incorporating tritiated thymidine, and compared in inflammatory and neoplastic disorders. An attempt at pathogenic classification is proposed.

Biopsy↗
PubMed1985

Neoplastic proliferation in a case of epidermotropic high-grade malignant lymphoma associated with hypercalcemia.

We report a case of epidermotropic high-grade malignant lymphoma associated with hypercalcemia occurring in a European woman aged 30 years. The clinical, histological, and biological presentation of the patient could enter the spectrum of HOTS (hypercalcemia, osteolysis, T cell lymphoma syndrome). The proliferation of neoplastic lymphocytes was very high in patch, plaques, and nodules of the skin.

Adult↗
PubMed1985

[Histiocytofibroma and Dupuytren's palmar fibromatosis. Comparative autohistoradiographic study of their proliferative and biosynthetic activities].

The proliferative rate and synthesis of proteins was studied in histiocytofibromas and in nodules of Dupuytren's palmar fibromatosis. Incorporations of tritiated thymidine and tritiated proline were used and revealed by autohistoradiography. In the two diseases, proliferation and protein synthesis occurred predominantly in cells of the vascular walls while the other cells constitutive of the lesions appeared less active.

Autoradiography↗
PubMed1985

[Anatomo-clinical presentation of graft-versus-host disease treated with cyclosporin A].

Evaluation of the clinical and histological signs of cutaneous graft-versus-host disease present in 7 patients treated with cyclosporin A was based on a follow-up of 100 days after bone marrow transplantation. Early clinical signs consisted of acral erythema with mild to moderate edema. Histologically, the graft-versus-host reaction was moderate but not completely inhibited. As revealed by autoradiography after labeling with tritiated thymidine and uridine, the lymphoid infiltrate had a low rate of proliferation and a normal or enhanced synthetic activity of ribonucleic acid.

Adolescent↗
PubMed1985

[Connective tissue compartments in scleroderma. Study of the structure and the biomechanical properties].

A combined histological and biomechanical study was performed in patients with localised or systemic scleroderma. The inflammatory reaction was variable in intensity and location, predominating around the superficial vascular plexus, the deep dermo-hypodermal plexus, the paraseptal plexus or in the fasciae. Secondary sclerosis resulted from the lateral fusion of bundles of collagen fibers. Three degrees of intensity of sclerosis were disclosed by our noninvasive technique of tonometry by vertical traction of the skin in vivo. That measurement allowed a follow-up of the evolution of the disease and a control of the therapeutic efficacy.

Connective Tissue↗
PubMed1985

[Trichome].

A 4 year-old boy presented an acute pruriginous dermatitis of the hands, forearms and abdomen. A skin surface biopsy revealed numerous trichomes, small prickles present on plants. These trichomes were those of prickly pears and stuck deeply in the skin, inducing an inflammatory reaction known as Sabra dermatitis. A number of plant dermatitides are due to the presence of trichomes such as those due to linden, primula, wild rose or nettle.

Child, Preschool↗
PubMed1984

Xerodermoid induced by photochemotherapy.

Photochemotherapy induces alterations in the skin that resemble those in xeroderma pigmentosum. Acute responses may be distinguished from late, chronic, and delayed responses to PUVA. All of the types of cells present in the skin are affected by photochemotherapy. The structure of the epidermis and of the superficial dermis are altered and, possibly as a consequence, neoplasms may ensue.

Bibliographies as Topic↗
PubMed1984

Replication of Paget cells in mammary and extramammary Paget's disease.

Replication of Paget cells in mammary and extramammary Paget's disease was evaluated by autoradiography after incorporation of tritiated thymidine. Neoplastic cells proliferated in the deepest layers of the epidermis suggesting a topographical control of their multiplication similar to that of the normal epidermis.

Adult↗