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Biomedical subjects

C Pierre

Publications and source records attributed to C Pierre.

68 records · Page 4Linked to original sources
PubMed1987

Pharmacokinetics of teicoplanin in critically ill patients with various degrees of renal impairment.

The pharmacokinetics of teicoplanin were studied in 15 adult patients in the acute phase of severe infections caused by gram-positive cocci. All the subjects were given a daily intravenous bolus dose of 6 mg of teicoplanin kg-1 (body weight). The pharmacokinetic study was performed over a 48-h period after injection 4. The subjects were categorized according to their mean creatinine clearances (ml.min-1.kg-1) during the study period: group 1 (n = 3), greater than 1.6; group 2 (n = 6), 0.8 to 1.6; and group 3 (n = 6), 0.15 to 0.8. Mean concentrations of teicoplanin in serum at 1, 24, and 48 h were 33 +/- 8, 9 +/- 3, and 6 +/- 2.5 micrograms.ml-1, respectively. The mean half-lives of the concentration-time curve from 12 to 48 h were 28 +/- 4, 44 +/- 24, and 48 +/- 14 h in groups 1, 2, and 3, respectively (group 3 versus group 1: P less than 0.05). The mean area under the serum concentration-time curve from time zero to 24 h was 344 +/- 92 mg.h.liter-1, and the mean hybrid volume of distribution was 1.09 +/- 0.46 liter.kg-1. These values were similar for the three groups, with a trend for larger areas under the curve in group 3. Creatinine clearance correlated directly with the total body clearance of teicoplanin (r = 0.70) and with the renal clearance of teicoplanin (r = 0.82). However, in critically ill patients, the wide interindividual variations in pharmacokinetic parameters are more relevant than those related to the variations in renal function when creatinine clearance is above 0.30 ml.min-1.kg-1. We concluded that, in such conditions, monitoring of concentrations of teicoplanin in serum is mandatory.

Adolescent↗
PubMed1987

[Thyroid carcinoma in an adult cystic teratoma of the ovary with bony metastases].

An oophorectomy specimen in a patient aged 36 showed a dermoid cyst with a struma ovarii and what was considered to be a folliculo-trabecular adenoma. Two osseous metastases appeared 4 and 8 years later respectively. The follow-up so far is 15 years. This is the twentieth reported case of mature cystic teratoma of the ovary containing metastating thyroid carcinoma.

Adult↗
PubMed1987

[Sacrococcygeal teratoma in 2 fetuses at 5 and 6 months].

The two large mature sacro-coccygeal teratomas reported seem to be responsible for the death of fetuses in the fifth and sixth months of pregnancy. A review of the literature shows that teratomas are exceptionally rare during this period. Their outcome depends upon the degree of maturity of the tumor, its size, whether its location is pelvic or not, the presence of any associated malformations and upon prematurity.

Adult↗
PubMed1986

[Rhinovirus and acute respiratory infections in infants].

Human leucocytary interferon (IFN) in a concentration of 2,000 Ul/ml stops the development of 9 Rhinovirus (RV) strains. The use of serum IFN antibodies (SAIF) reverses this effect. Of 256 nasal aspirates culture negative for other respiratory viruses, 40 RV were isolated with SAIF as opposed to 19 without serum anti IFN. The frequency and some clinical aspects are emphasized in infants: 43% had bronchiolitis similar to respiratory syncytial virus (RSV) infections and atopy was frequent.

Acute Disease↗
PubMed1983

Mortality in an european cohort occupationally exposed to epichlorohydrin (ECH).

A study was undertaken on the mortality of workers exposed to ECH at four European sites with plants producing epichlorohydrin (ECH), epoxy resins, glycerin, and other specialty chemicals derived from ECH. The vital status of 606 individuals with at least one year of exposure to ECH, starting at least 10 years before the final date of the study on 31 December, 1978, were collected. Mortality was analysed for a subgroup with 10 or fewer years of exposure, and another subgroup with more than 10 years of exposure. Four deaths from different cancers were observed against five expected. No excess mortality from cancer was observed in either subgroup or the complete cohort, which could be related to ECH exposure. The small size of the cohort and the limited number of deaths due to low average age (42 years), as well as the short duration of the observation period, do not allow a firm conclusion to be reached regarding the potential carcinogenicity of ECH in man. Current exposure levels are low, but exposure in the early days of production occasionally reached levels high enough to be irritating. We recommend updating the study 5 years from the final date of the present study, i.e. on 31 December, 1983. Within their limitations this and other epidemiological studies so far provide no evidence for an association between occupational exposure to ECH and the occurrence of malignant neoplasms in man.

Chlorohydrins↗
PubMed1983

Freeze-dried skin allografts. A human clinical and histological study.

Free gingival autografts still remain the most predictable method for creating attached gingiva. However, a need exists for sources of connective tissue other than the patient's own connective tissue. Yukna et al. have proposed freeze-dried skin (FDS) allografts as a substitute for gingival autografts. The purpose of the present study was to evaluate FDS allografts on humans, clinically and histologically. Ten FDS allografts and two free gingival (FG) autografts were performed on ten patients, two of them receiving both FDS and FG grafts. Clinical measurements were made before surgery, immediately after surgery and then 2 and 6 months after surgery. After 4 and 24 months, biopsies were performed on both FG and FDS grafts. Routine histologic staining was done. The results show a mean gain of attached gingiva of 0.32 mm with a range from 0 to 0.8 mm. Compared biopsies sections of FDS allografts and FG autografts show that the tissue obtained with the FDS allografts do not display the histomorphologic pattern of attached gingiva. The FDS allografts do not seem to represent a good substitute to free gingival autografts. However, they might be used successfully as a biological bandage.

Adult↗
PubMed1982

Skin preservation by programmed freezing.

There are several occasions when it may be useful to preserve skin grafts for at least 15 days, in a good enough state to provide viable autografts. We describe a technique of cryopreservation which facilitates this type of procedure. Stretched sheets of skin are incubated in a protective medium. Freezing is programmed with cooling rates of 1 degree/min first to 50 degrees C and 5 degrees/min thereafter. The skin is placed in bags that are stored in liquid nitrogen and when required for use is rapidly thawed. Thin and ultra-thin sections of this preserved skin were studied by light and electron microscopy. Cultures wer made from thawed skin and growing cells were found to contain epithelial-like or fibroblast-like elements. When pieces of thawed skin were replaced on their original donor site the autograft was successful. The technique we have described gave consistently good results and its clinical applications need further development and study.

Cryoprotective Agents↗
PubMed1982

[Method for study and histological evaluation of the uterus (author's transl)].

The technique of examination and sampling of a cone biopsy or hysterectomy specimen fulfils precise criteria which make it possible to make or confirm a diagnosis and to evaluate prognosis on the basis of complete excision or the state of spread of the lesion. Routinely cone specimen is examined in at least six sections from the anterior lip and at least six from the posterior lip. The uterus must be weighed, measured, oriented, opened in the frontal plane and specimens taken with precise topographical identification, examination of the fresh specimen and of small but multiple and selected specimens is recommended.

Adult↗
PubMedDate not supplied

Participating in clinical trials: a guide for practices.

Physicians who participate in clinical research studies gain benefits for themselves, their practice, and their patients. Private practice physicians have traditionally chosen to defer to their counterparts in academic medicine when it comes to contributing to scientific advancement through clinical trials. A growing number, however, now are taking a serious second look and deciding that there are unique benefits for both the practice and the patient. Physicians who decide to participate in clinical trials should give serious consideration to the time and dedication of staff and other resources that are required to meet both federal regulations and industry standards. In addition, ethical and scientific principles of assuring the protection of human research subjects must be a paramount concern.

Clinical Trials as Topic↗