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C Poirel

Publications and source records attributed to C Poirel.

At least 19 recordsLinked to original sources
PubMed1991

Circadian aspects of epileptic behavior in comparative psychophysiology.

This paper is concerned with some experimental and clinical problems regarding the circadian chronobiology of epilepsy. Rhythmometrically analyzed, the temporal fluctuations of seizure susceptibility tend to indicate that epileptic events are circadian stage-dependent processes whose chronobiologic characteristics are possibly predictable on the basis of mathematical models. As an integrative discipline in physiology and psychology, behavioral chronobiology renders possible the discovery of new regulation processes concerning the central mechanisms of epilepsy. In this respect, the circadian psychophysiological patterns of epilepsy express dynamical biological systems which suggest some intermodulating endogenous processes between vigilance level and seizure susceptibility. Moreover, such chronobiologic studies applied to epileptic behavior suggest the development of new heuristic aspects in the field of comparative psychophysiology.

Arousal↗
PubMed1988

Rhythmometric analyses of circadian variations of grooming behavior in the mouse: research perspectives in behavioral chronobiology.

A circadian biologic time structure of grooming behavior may be detected on the basis of chronobiologic procedures. Results are presented and discussed in the broader scope of a series of behavioral chronobiologic studies with comparison of standard biometric and rhythmometric analyses. Moreover, such experiments provide a quantitative approach for a better functional understanding of psychophysiological mechanisms regulating the stress-related grooming behavior. Such circadian studies show also that chronobiology raises some working hypotheses in experimental psychology and permits the development of new heuristic concepts in the field of behavioral neuroscience.

Acoustic Stimulation↗
PubMed1987

Circadian patterns of vigilance and seizure susceptibility in genetically epileptic mice: heuristic aspects in neurology.

A circadian paradigm of susceptibility to tonic-clonic convulsions was experimentally analyzed in genetically epileptic mice. In conjunction with behavioral and neurochronobiological studies, we demonstrated from these animal models that the tonic-clonic susceptibility appears to be modulated by the vigilance level. Thanks to biometric and inferential rhythmometric procedures, the chronobiological data obtained and the complementary psychophysiological investigations performed in this study suggest several heuristic perspectives concerning the central pathophysiology of epilepsy. The results obtained within the field of the neurosciences are consistent with the hypothesis suggested by chronobiology that central hyperactivation negatively influences the tonic-clonic susceptibility. Such experiments respectively conducted in chronobiology and fundamental neurology provide a quantitative approach for a better understanding of some brain mechanisms regulating seizure susceptibility.

Animals↗
PubMed1984

Circadian rhythms and temporal structure of the susceptibility to tonic-clonic seizures in the mouse.

A circadian paradigm of susceptibility to tonic-clonic convulsions was established for two strains of mice. This research dealt with rhythmometric methods for estimating the main circadian parameters characterizing the temporal structure of these behavioral phenomena. Such experiments provided a quantitative approach for studying some neurobiological mechanisms regulating the seizure susceptibility.

Acoustic Stimulation↗
PubMedDate not supplied

[Chronobiological paradigms of mental life and clincial neurosciences]].

Circadian fluctuations of normal and abnormal behavioural processes have been classically reported from statistically validated chronograms (averaged displays of data as a function of time). Going more deeply into the research with rhythmometric investigations reveals that the temporal organization of psychophysiological functions involving several oscillatory systems may compose possible circadian paradigms of brain integration and pathological chronorisk for clinical neuroscience (seizure susceptibility for epilepsy and related states, brain circulatory disturbances, stress-related events, emotional or affective manifestations, and psychosomatic disorders). Rhythmometrically analyzed, the temporal fluctuations of behavioural events tend to indicate that cerebral integrations are circadian, circaseptidian or infradian stage-dependent processes whose chronobiologic characteristics are possibly predictable on the basis of mathematical models. More generally, the present study reveals that: 1) several neurological or psychiatric disorders are directly or indirectly concerned with chronobiologic processes, and that 2) cerebral and behavioural time variations can be detected and described in neurology and psychiatry as algorithmically-formulatable recurring psychophysiological changes with a waveform validated by inferential statistical computer methods. Such rhythmometric procedures applied to neurological or psychiatric events suggest also the development of new epistemological concepts in the fields of comparative psychophysiology and theoretical neuroscience.

Algorithms↗
PubMedDate not supplied

Circadian chronobiology of epilepsy: murine models of seizure susceptibility and theoretical perspectives for neurology.

As an integrative discipline in physiology and medical research, chronobiology renders possible the discovery of new regulation processes regarding the central mechanisms of epilepsy. In this context, the temporal fluctuations of seizure susceptibility rhythmometrically detected tend to demonstrate 1. that tonic-clonic events are circadian stage-dependent processes whose temporal characteristics (i.e. MESOR, amplitude, acrophase) and clinical parameters (e.g. neurological components, severity of motor discharges) are predictable on the basis of mathematical models, and 2. that the generalized epileptic onsets may respond to telencephalic integrations modulated by centrencephalic circadian processes of vigilance. Considering the data model assumed for our rhythmometric analyses, the circadian psychophysiological patterns of epilepsy also express dynamic biologic systems which reveal some intermodulating endogenous processes between vigilance and seizure susceptibility. The new chronophysiology investigations considered at a rhythmometric level of resolution suggest several heuristic perspectives regarding 1. the central pathophysiology of epilepsy and 2. the behavioral classification of convulsive events. Such circadian studies also show that chronobiology raises some working hypotheses in psychophysiology and permits the development of new theoretical concepts in the field of neurological science.

Animals↗
PubMedDate not supplied

Circadian patterns of basic emotional reactivity and stress related events revisited in mice treated with lithium: behavioral rhythmometric analyses.

This research dealt with rhythmometric methods for estimating and comparing the main temporal parameters characterizing the circadian structure of behavioral events in mice with and without lithium treatment. Such comparative chronobiologic studies would tend to demonstrate in psychophysiology that this drug does not displace the circadian patterns of basic emotionality, but does displace some behavioral circadian rhythms associated with more corticalized integrations. The present behavioral observations would tend to support the hypothesis that lithium salts modify the circadian structure of emotionality by cortical modulation rather than only by physiological subcortical integrations. Such circadian studies show also that behavioral chronobiology raises some working hypotheses in comparative ethology and permits the development of new heuristic concepts in the field of biological psychiatry.

Animals↗