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Biomedical subjects

C Pomeroy

Publications and source records attributed to C Pomeroy.

64 records · Page 4Linked to original sources

Cytomegalovirus: epidemiology and infection control.

Cytomegalovirus (CMV) causes asymptomatic infection in most individuals but can produce devastating illness in immunocompromised hosts and in a small proportion of congenitally infected babies. New techniques in molecular biology have provided insights into the epidemiology and transmission of CMV. Children in day care, their parents, and sexually active individuals, especially homosexual men, are now known to be at particular risk for acquiring CMV. Recent studies show that the risk of CMV acquisition by health care workers is similar to the risk to the general public. Health care workers should be aware of the wide range of clinical manifestations, methods of laboratory diagnosis, and current limitations of treatment of CMV. Careful handwashing and avoidance of excretions and secretions are recommended to decrease the transmission of CMV in the hospital.

Adult↗

Selenomonas bacteraemia--case report and review of the literature.

Selenomonas species are crescent shaped Gram-negative bacilli with a characteristic tuft of flagella located on the concave surface. They are normally found in human gingiva or the rumen of herbivores. The first case of Selenomonas bacteraemia to be reported in a patient immunocompromised by malignant disease is described and the two previously reported cases of Selenomonas bacteraemia as reviewed. The importance of careful anaerobic culturing to recover the organism and special diagnostic techniques to classify the bacteria as Selenomonas species are emphasised. These organisms may cause serious human disease including bacteraemia.

Aged↗

Medical complications and medical management of bulimia.

The syndrome of bulimia is a common disorder and can be associated with serious psychological and physical morbidity. Unfortunately, many patients are reluctant to discuss their symptoms with their physicians and few clues can be found on physical examination to aid in the diagnosis. Possible physical signs include ulceration or scarring of the dorsum of the hand, salivary gland hypertrophy, and dental enamel erosion. In laboratory testing it is fairly common for patients with active bulimia to have fluid and electrolyte abnormalities, particularly hypokalemic alkalosis, and some also have elevated serum amylase levels. Rare complications include myopathies from misuse of ipecac, ruptured esophagus and pneumomediastinum associated with vomiting, and subtle abnormalities in neuroendocrine regulatory systems. Medical management including monitoring of fluid and electrolyte balance is essential during treatment.

Bulimia↗

Budd-Chiari syndrome in a patient with the lupus anticoagulant.

Lupus anticoagulant is an immunoglobulin that interferes with prothrombin conversion to thrombin and is manifested biochemically by prolongation of the partial thromboplastin time. Paradoxically, bleeding is rare in association with this anticoagulant, and deep leg vein thromboses, pulmonary emboli, and cerebrovascular accidents have been described in patients with this clotting inhibitor. This report describes the first case of Budd-Chiari syndrome associated with the lupus anticoagulant. The patient presented with abdominal pain and massive ascites. The Budd-Chiari syndrome was confirmed by liver biopsy and venography. No medical condition known to predispose to an increased thrombotic tendency could be identified, and the presence of the lupus anticoagulant in the patient's plasma may provide an explanation for his hypercoagulability and development of the Budd-Chiari syndrome.

Adult↗

Evaluation of the gallbladder by gray scale ultrasonography.

A review of the results of the evaluation of the gallbladder by gray scale ultrasonography in 52 patients is presented. When the gallbladder was successfully identified by ultrasound (46 patients) the detection of stones was 98% accurate. When the gallbladder was not identified (four patients), a contracted gallbladder containing numerous stones was found at operation. The left lateral decubitus position proved very helpful in displaying the gallbladder when it could not be identified in the standard supine position. Ultrasonic evaluation of the gallbladder is of most value in the patients who have had unsuccessful radiographic studies.

Cholelithiasis↗

Reducing the transmission of HIV-1: needle bleaching as a means of disinfection.

OBJECTIVE: To review the efficacy, safety, and proper methods for use of bleach (sodium hypochlorite) as a means of needle disinfection. DATA SOURCES: Controlled studies cited in MEDLINE between 1966 and 1999 using indexing terms: needle, bleach, HIV/AIDS, and disinfection. STUDY SELECTION AND DATA EXTRACTION: Studies were categorized based on experimental conditions produced and specific testing procedures used. DATA SYNTHESIS: Used properly, undiluted bleach (sodium hypochlorite 5.25%) appears to be an effective disinfection solution for used needles. Proper needle disinfection with undiluted bleach may reduce the risk of HIV transmission among injection drug users from needle sharing. CONCLUSION: Pharmacists can play a role in reducing HIV transmission among injection drug users by advocating cessation of drug use, drug treatment programs, and avoidance of needle sharing. Pharmacists should be prepared to educate patients who are unwilling to cease illicit drug use or participate in drug treatment programs on the proper methods of bleach disinfection of used needles.

Acquired Immunodeficiency Syndrome↗

Preventing secondary infections among HIV-positive persons.

Secondary infectious diseases contribute substantially to morbidity and mortality of people infected with human immunodeficiency virus (HIV). The authors developed comprehensive, practical recommendations for prevention of infectious complications in HIV-infected people. Recommendations are concerned with the pathogens that are more common or more severe in HIV-infected people. Several infectious complications can be prevented by avoiding ingestion of contaminated food or water. Zoonoses can be prevented by precautions to be taken in contacts with animals. The risk of several fungal diseases can be reduced if activities likely to lead to inhalation of spores are avoided. HIV-infected people should be advised how to lower adverse health effects of travel, especially international travel. The potential for infectious complications of sexual activity and illicit drug use should be stressed, and recommendations to reduce the risk are discussed. Recommendations for use of vaccines in HIV-infected people are reviewed. Blood CD4+ lymphocyte concentrations, tuberculin skin testing, Toxoplasma serology, and sexually transmitted disease screening should be performed in certain subsets of HIV-infected people. Guidelines for chemoprophylaxis against Pneumocystis carinii and tuberculosis are presented. Recent data suggest that intravenous immunoglobulin therapy may prevent bacterial infections in HIV-infected children.

Animals↗