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Biomedical subjects

C Ponvert

Publications and source records attributed to C Ponvert.

26 records · Page 2Linked to original sources
PubMed1983

Skin inflammation induced by hypomagnesaemia in the rat.

Hairless rats fed a hypomagnesaemic diet developed an inflammatory dermatosis characterized by papular erythematous plaques. The dermatosis was long-lasting and could be observed for up to 6 months. It was inhibited by intraperitoneal injection of magnesium or dexamethasone but not by mepyramine, cimetidine, theophylline, aspirin or indomethacin. Analysis of semithin sections only showed oedema in the epidermis and superficial dermis with occasional intra-epidermal splitting. Direct immunofluorescence did not detect immunoreactant deposits within epidermis or dermis. Hypomagnesaemic dermatosis in hairless rats is proposed as a model for the pharmacological study of skin inflammation.

Animals↗
PubMed1980

[Histamine receptor bearing mononuclear cells in children with atopic dermatitis (author's transl)].

The frequency of mononuclear cells bearing membrane receptors for histamine was investigated in peripheral blood from children with atopic dermatitis (AD) by means of the rosettes histamine assay, using sheep erythrocytes coated with histamine. Histamine rosettes (HR) varied from 5.70 to 11.25 p. 100 in healthy adults; from 3.25 to 7.75 p. 100 in control children and from 2 to 6.55 p. 100 in children with AD. The reaction was specific as histidine and tryptamine only slightly inhibited HR formation, whereas free histamine, histamine H1 and H2 antagonists (neo antergan and metiamide) and the histamine H1 agonist (dimaprit) reduced HR formation much more strongly. The inhibition of the HR formation by all these agents was not found to be significantly different in normal children and in children with AD. However the reduction of the HR formation by a previous incubation with histamine was not constant in children with AD.

Adolescent↗
PubMed1978

Leucocyte migration test and hypersensitivity to glafenin.

The leucocyte migration test (LMT) was performed on 20 patients with an intolerance to glafenin--a non-narcotic analgesic drug. LMT was found to be positive in 50% of the subjects with intolerance, a highly significant percentage as compared with the control groups. HSA-glafenin was found to be the most appropriate method for presenting the antigen, but glafenin and its hydroxylated metabolites were only found to induce a migration inhibition in the subjects intolerant to glafenin.

Adult↗
PubMed1976

Lymphocyte transformation, leucocyte migration, specific IgE, IgG and IgM before, during, and after penicillin treatment without adverse reaction. A follow-up study.

This in vitro follow-up study of the penicillin-induced immune response by a well-tolerated regimen was conducted with an association of four tests: lymphocyte transformation test; leucocyte migration test; passive anaphylaxis on monkey lung tissue; and passive hemagglutination. It showed (1) that previously sensitized subjects (including IgE) tolerated the treatment by pencillin. (2) That the treatment induced either a transient positive conversion of previously negative tests or a negative conversion of previously positive tests. These in vitro findings are in accordance with previously established concepts based upon cutaneous tests and must be taken into consideration when interpretating in vitro diagnosis of penicillin allergy.

Adolescent↗
PubMed1976

The penicillin antigens: presentation in the leucocyte migration test (a study with penicillin and penicilloylated proteins).

The response of the leucocyte migration test (LMT) to benzyl penicillin (BP) was compared with the response of LMT to benzyl penicilloylated human gamma globulins (BPO HGG) and to benzyl penicilloylated human serum albumin (BPO HSA). Patients with and without hypersensitivity to penicillins were investigated. No statistical differences were found between the response to BP and to BPO HGG or BPO HSA; this finding supports the fact that the BPO groups generated by BP are mainly implicated in the triggering of the LMT when BP is used as antigen. A strongly penicilloylated HSA appeared to be the most effective mode of the antigen presentation for the detection of BPO-specific cellular immunity in patients with and without clinical symptoms of hypersensitivity to the penicillins.

Adult↗