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Biomedical subjects

C Poole

Publications and source records attributed to C Poole.

15 recordsLinked to original sources
PubMed1991

Iridium implant treatment without external radiotherapy for operable breast cancer: a pilot study.

A pilot study has been conducted to examine a new approach to the treatment of operable breast carcinoma. 27 patients with tumours measuring up to 4 cm in diameter have been treated by tumourectomy, axillary clearance and high dose iridium-192 implant (55 Gy) without any external beam radiotherapy. This enabled the entire local primary treatment of the breast carcinoma to be given in five days. The technique was compatible with adjuvant chemotherapy for those with involved axillary nodes. Local complications have been few and locoregional control has to date been satisfactory. With a relatively short median follow-up of 27 months, cosmesis was objectively rated as good or excellent in over 80% of cases and subjectively rated good/excellent in 96%. High dose brachytherapy now requires testing in a prospective clinical trial to determine whether it is as effective as standard breast conservation techniques for management of early breast cancer.

Adult↗
PubMed1991

The importance of added albumin during continuous intravenous infusion of interleukin-2 with alpha-interferon.

We treated 14 patients (4 malignant melanoma/10 renal carcinoma) with a combination of continuous infusion interleukin-2 (IL-2) and subcutaneous alpha-interferon. Variable concentrations of albumin were added to the infusion of IL-2. The toxicity of this regimen seems to be related to the percentage of albumin added to the IL-2 infusion. Partial responses were observed in 3 cases. Interestingly, 1 patient's response appeared dependent on the addition of human serum albumin. The mechanism of these effects is unknown, but the use of albumin with IL-2 should be carefully investigated in future studies.

Adolescent↗
PubMed1989

Proviral position effects: possible probes for genes that suppress transcription.

Rous sarcoma virus, an oncogenic avian retrovirus, readily causes morphological transformation of chick cells, but in infected rat cells transformation is rare because proviral transcription is inefficient. This constraint is not due to a lack of positive transcriptional factors, or an excess of negative ones, but reflects the site of proviral integration in rat cell DNA. In most sites the provirus is almost invariably silent, in others it is correspondingly active, whilst in a third category expression fluctuates in concert with transitions in chromatin structure. Transcriptional fluctuations are mediated both by flanking cell DNA in cis and by trans-acting cell genes, suggesting that proviral position effects are sensors for genes that down-regulate transcription, perhaps by determining chromatin configuration. We have tried to identify such genes by gene transfer, karyology and insertional mutagenesis. The variable success of these three approaches indicates that the transcriptional down-regulator(s) need act only transiently. This is consistent with a function that operates in ontogeny or differentiation to down-regulate genes whose silence is then perpetuated by other means. The loss of such functions may predispose to neoplasia.

Animals↗
PubMed1979

Congenital bilateral subclavian steal: ductus-dependent symptoms in interrupted aortic arch associated with ventricular septal defect.

There are two types of congenital bilateral subclavian steal. The first type is accompanied by severe coarctation or interruption of the aorta in which both the right and left subclavian arteries have their origin distal to the obstruction in the aorta. In most cases with complete interruption of the aorta there is a large ventricular septal defect. The second, less common type of steal is associated with isolated atresia of the proximal segment of the subclavian arteries. In the first type of steal, the anatomic predisposition for the steal is present from birth but clinical symptoms frequently do not appear until childhood or adolescence. In the newborn the presence of a widely patent duclus arteriosus and its capacity to transmit the flow and pressure from a hypertensive pulmonary artery to the descending aorta and thus to the subclavian arteries prevents cerebral symptoms and angiographic signs, but in the older infant and child, the internal diameter of the ductus has usually decreased, leading to symptoms of the subclavian steal syndrome.

Angiocardiography↗
PubMed1976

Contraception and the adolescent female.

Although most teenagers have some knowledge of birth control methods, most sexually active adolescents do not use one consistently. Some young women are too apathetic or irresponsible to use birth control, even if the method is available. However, most teenagers do not want to become pregnant. If factual information is given, the method is easily accessible and is acceptable to them, and if they have come to terms with their own sexuality, most young women will accept the responsibility of preventing an unwanted pregnancy.

Adolescent↗
PubMed1975

Cognitive and nonverbal perceptual processing in dyslexics.

A sample of 33 dyslexic and 33 control children were compared on tasks involving visual matching with spatial transformation (VMST), tactual serial matching (TSM), visual sequential memory (VSM), and auditory sequential memory (ASM). Contrary to expectation, the dyslexics performed at the same level as controls on VMST. This result was not explicable as a floor or ceiling effect and was considered evidence that dyslexics do not suffer impairment in visual spatial transformation ability per se. Dyslexics were not significantly different on TSM, but were inferior to controls on VSM and ASM.

Child↗